Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 21,276–21,300 of 27,380 studies, newest first · page 852 of 1096.
September 2009 25
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2009-09-16
A clinico-pathological study of subtypes in Parkinson's disease
69/100 ✓ Peer-reviewed Lewy body dementia Brain : a journal of neurology
Key finding: We found a strong association between a non-tremor dominant disease pattern and cognitive disability. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-16
TDP-43 is recruited to stress granules in conditions of oxidative insult
51/100 ✓ Peer-reviewed Lewy body dementia Journal of neurochemistry
Key finding: We found that in response to oxidative stress and to environmental insults of different types TDP-43 is capable to assemble into stress granules (SGs), ribonucleoprotein complexes where protein synthesis is temporarily arrested. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-14
Reversal of long-term dendritic spine alterations in Alzheimer disease models
47/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: We have previously reported the loss of dendritic spines and the presence of dystrophic neurites in both the hippocampi of transgenic mice overexpressing amyloid precursor protein (APP) and in the human brain affected with AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-14
The diseasome of physical inactivity--and the role of myokines in muscle--fat cross talk
50/100 ✓ Peer-reviewed Prevention and risk The Journal of physiology
Key finding: Both physical inactivity and abdominal adiposity, reflecting accumulation of visceral fat mass, are associated with the occurrence of the diseases within the diseasome. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-09-09
Functional levels and nurse workload of elderly awaiting nursing home placement and nursing home residents: a comparative study
37/100 ✓ Peer-reviewed Health systems and care delivery Scandinavian Journal of Caring Sciences
Key finding: A comparison of the functional levels between elderly awaiting nursing home placement and nursing home residents showed few statistically significant differences. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-08
Epidemiology of psychosis in Parkinson's disease
54/100 ✓ Peer-reviewed Caregiving Journal of the neurological sciences
Key finding: Prospective longitudinal cohort studies suggest that hallucinations persist and worsen in individual patients, and that their prevalence increases with time. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-09-06
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
64/100 ✓ Peer-reviewed Risk genes beyond APOE Nature Genetics
Key finding: Replicated evidence of association was found within CLU (rs11136000, OR = 0.86, 95% CI 0.81-0.90, P = 7.5 x 10(-9) for combined data) on chromosome 8. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-06
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
66/100 ✓ Peer-reviewed Risk genes beyond APOE Nature Genetics
Key finding: Replicated the established association with the apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P = 1.8 x 10(-157)) +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-06
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis
64/100 ✓ Peer-reviewed How common it is Nature genetics
Key finding: Analysis of the genome-wide data revealed genome-wide significance for one SNP, rs12608932, with P = 1.30 x 10(-9).
Full summary, score breakdown and related studies → Original source
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2009-09-04
Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly
47/100 ✓ Peer-reviewed Mild cognitive impairment Environmental research
Key finding: Animal studies have suggested that fine particulate matter (PM) can translocate from the upper respiratory tract to the brain and cause brain inflammation. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-04
The epidemiology of dementia associated with Parkinson disease
47/100 ✓ Peer-reviewed Getting a diagnosis Journal of the neurological sciences
Key finding: Several recent studies have shown that dementia is common in Parkinson's disease (PD), and that in some patients, cognitive impairment occurs even at the time of diagnosis. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-02
Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls
47/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: The [(11)C]PIB uptake of the patients with AD did not increase significantly during follow-up when compared with that of the controls. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-09-02
Reelin signaling antagonizes beta-amyloid at the synapse
44/100 ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America
Key finding: Reelin is a neuromodulator that increases glutamatergic neurotransmission by signaling through the postsynaptic ApoE receptors Apoer2 and Vldlr and thereby potently enhances synaptic plasticity. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-01
Systemic inflammation and disease progression in Alzheimer disease
55/100 ✓ Peer-reviewed Inflammation and the immune system Neurology
Key finding: Both acute and chronic systemic inflammation, associated with increases in serum tumor necrosis factor alpha, is associated with an increase in cognitive decline in Alzheimer disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-01
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
36/100 ✓ Peer-reviewed Risk factors Nature reviews. Drug discovery
Key finding: Nicotinic receptors - a family of ligand-gated ion channels that mediate the effects of the neurotransmitter acetylcholine - are among the most well understood allosteric membrane proteins from a structural and functional perspective. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-01
Ultrasensitive and highly selective detection of Alzheimer's disease biomarker using two-photon Rayleigh scattering properties of gold nanoparticle
36/100 ✓ Peer-reviewed Drug development ACS nano
Key finding: We have shown that when anti-tau antibody-coated gold nanoparticles were mixed with 20 ng/mL of tau protein, two-photon Rayleigh scattering intensity (TPRS) increases by about 16 times. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-01
Cholinesterase inhibitor and N-methyl-D-aspartic acid receptor antagonist use in older adults with end-stage dementia: a survey of hospice medical directors
36/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine
Key finding: The findings from this survey indicate that cholinesterase inhibitors and/or NMDA receptor antagonists are prescribed for a subset of patients with advanced dementia and that a proportion of hospice medical directors report clinical benefit from the ongoing use of these agents. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-09-01
Hospice care in the nursing home setting: a review of the literature
36/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management
Key finding: Research has shown that NH-hospice collaborations require effective communication around residents' changing care needs and that a range of barriers can impede the integration of hospice and NH care.
Full summary, score breakdown and related studies → Original source
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2009-09-01
Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls
54/100 ✓ Peer-reviewed Cognitive tests and assessment Human brain mapping
Key finding: After training the classifier on 21 hand-labeled expert segmentations, we created binary maps of the hippocampus for three age- and sex-matched groups: 100 subjects with Alzheimer's disease (AD), 200 with mild cognitive impairment (MCI) and 100 elderly controls (mean age: 75.84; SD: 6.64). +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-01
Treatment of vascular risk factors is associated with slower decline in Alzheimer disease
61/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology
Key finding: The aim of this observational study was to evaluate whether the treatment of VRF is associated with a slower cognitive decline in patients who have AD without cerebrovascular disease (CVD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-01
Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts
64/100 ✓ Peer-reviewed Mild cognitive impairment Archives of neurology
Key finding: These findings add to the growing literature to suggest that the degree of functional impairment at baseline is an important predictor of conversion to dementia and may help explain differences in findings between epidemiological and clinic-based studies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-01
Total and cause-specific mortality in the cardiovascular health study
58/100 ✓ Peer-reviewed Disparities The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: In these older adults, associations of risk factors with a given cause of death were related to specific deficits in that same organ system. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-09-01
Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease
50/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: This effect is independent of baseline neuropsychological and MRI predictors. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-09-01
The effects of counseling spouse caregivers of people with Alzheimer disease taking donepezil and of country of residence on rates of admission to nursing homes and mortality
59/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Earlier NH admission of Australian compared to U.K. and U.S. subjects may be due to differences in health care, NH systems, availability, and affordability. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-09-01
Atomoxetine augmentation of cholinesterase inhibitor therapy in patients with Alzheimer disease: 6-month, randomized, double-blind, placebo-controlled, parallel-trial study
59/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Addition of ATX to ongoing cholinesterase-inhibitor therapy was generally well tolerated but did not significantly improve cognitive function. +4 more findings
Full summary, score breakdown and related studies → Original source
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