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Effect of fish oil on cognitive performance in older subjects
Ondine van de Rest, Johanna Marianne Geleijnse, F.J. Kok, Wija A. van Staveren, Carla Dullemeijer, Marcel G.M. Olde-Rikkert, Aartjan T.F. Beekman, C.P.G.M. de Groot. Neurology, 2008-08-04
Topic: Gut, metabolism and diet
The mean age of the participants was 70 years, and 55% were male. Plasma concentrations of EPA-DHA increased by 238% in the high-dose and 51% in the low-dose fish oil group compared with placebo, reflecting excellent compliance. Baseline scores on the cognitive tests were comparable in the three groups. Overall, there were no significant differential changes in any of the cognitive domains for either low-dose or high-dose fish oil supplementation compared with placebo. In this randomized, double-blind, placebo-controlled trial, we observed no overall effect of 26 weeks of eicosapentaenoic acid and docosahexaenoic acid supplementation on cognitive performance.
Key findings
- The mean age of the participants was 70 years, and 55% were male.
- Plasma concentrations of EPA-DHA increased by 238% in the high-dose and 51% in the low-dose fish oil group compared with placebo, reflecting excellent compliance.
- Baseline scores on the cognitive tests were comparable in the three groups.
- Overall, there were no significant differential changes in any of the cognitive domains for either low-dose or high-dose fish oil supplementation compared with placebo.
- In this randomized, double-blind, placebo-controlled trial, we observed no overall effect of 26 weeks of eicosapentaenoic acid and docosahexaenoic acid supplementation on cognitive performance.
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Study details
- Effect sizeincreased by 238%
- Evidence strengthHigh
How this study scored 55/100
Published in a leading specialty journal. Scored zero for study design, sample size and studied in people because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 32 of the 58 points we could judge it on, which is 55 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2008 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 18678826) |
| Free to read | 2 / 2 | Free to read |
| Points | 32 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 32 of the 58 points we could judge it on is 55 out of 100. |
| Total | 55 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
van de Rest, O., Geleijnse, J. M., Kok, F., van Staveren, W. A., Dullemeijer, C., Olde-Rikkert, M. G., et al. (2008). Effect of fish oil on cognitive performance in older subjects. Neurology. https://doi.org/10.1212/01.wnl.0000324268.45138.86
Vancouver
van de Rest O, Geleijnse JM, Kok F, van Staveren WA, Dullemeijer C, Olde-Rikkert MG, et al. Effect of fish oil on cognitive performance in older subjects. Neurology. 2008. doi:10.1212/01.wnl.0000324268.45138.86. PMID: 18678826.
BibTeX
@article{vanderest2008-18678826,
author = {van de Rest, Ondine and Geleijnse, Johanna Marianne and Kok, F.J. and van Staveren, Wija A. and Dullemeijer, Carla and Olde-Rikkert, Marcel G.M. and Beekman, Aartjan T.F. and de Groot, C.P.G.M.},
title = {{Effect of fish oil on cognitive performance in older subjects}},
journal = {Neurology},
year = {2008},
doi = {10.1212/01.wnl.0000324268.45138.86},
pmid = {18678826},
url = {https://doi.org/10.1212/01.wnl.0000324268.45138.86}
}
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