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43/100

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Mild cognitive impairment

Topic: Amyloid, tau and blood-test diagnosis

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive decline in multiple cognitive domains. Its pathological hallmarks include senile plaques and neurofibrillary tangles. Mild cognitive impairment (MCI) is the earliest detectable stage of AD with limited symptomology and no dementia. The yearly conversion rate of patients from MCI to AD is 10-15%, although conversion back to normal is possible in a small percentage. Early diagnosis of AD is important in an attempt to intervene or slow the advancement of the disease. Early AD (EAD) is a stage following MCI and characterized by full-blown dementia; however, information involving EAD is limited. Oxidative stress is well-established in MCI and AD, including protein oxidation. Protein nitration also is an important oxidative modification observed in MCI and AD, and proteomic analysis from our laboratory identified nitrated proteins in both MCI and AD. Therefore, in the current study, a proteomics approach was used to identify nitrated brain proteins in the inferior parietal lobule from four subjects with EAD. Eight proteins were found to be significantly nitrated in EAD: peroxiredoxin 2, triose phosphate isomerase, glutamate dehydrogenase, neuropolypeptide h3, phosphoglycerate mutase1, H(+)- transporting ATPase, alpha-enolase and fructose-1,6-bisphosphate aldolase. Many of these proteins are also nitrated in MCI and late-stage AD, making this study the first to our knowledge to link nitrated proteins in all stages of AD. These results are discussed in terms of potential involvement in the progression of this dementing disorder.

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APA 7th

Reed, T. T., Pierce, W. M., Turner, D. M., Markesbery, W. R., & Allan Butterfield, D. (2009). Proteomic identification of nitrated brain proteins in early Alzheimer's disease inferior parietal lobule. Journal of cellular and molecular medicine. https://doi.org/10.1111/j.1582-4934.2008.00478.x

Vancouver

Reed TT, Pierce WM, Turner DM, Markesbery WR, Allan Butterfield D. Proteomic identification of nitrated brain proteins in early Alzheimer's disease inferior parietal lobule. Journal of cellular and molecular medicine. 2009. doi:10.1111/j.1582-4934.2008.00478.x. PMID: 18752637.

BibTeX

@article{reed2009-18752637,
  author  = {Reed, T. T. and Pierce, W. M. and Turner, D. M. and Markesbery, W. R. and Allan Butterfield, D.},
  title   = {{Proteomic identification of nitrated brain proteins in early Alzheimer's disease inferior parietal lobule}},
  journal = {Journal of cellular and molecular medicine},
  year    = {2009},
  doi     = {10.1111/j.1582-4934.2008.00478.x},
  pmid    = {18752637},
  url     = {https://doi.org/10.1111/j.1582-4934.2008.00478.x}
}

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Key findings

Eight proteins were found to be significantly nitrated in EAD: peroxiredoxin 2, triose phosphate isomerase, glutamate dehydrogenase, neuropolypeptide h3, phosphoglycerate mutase1, H(+)- transporting ATPase, alpha-enolase and fructose-1,6-bisphosphate aldolase.
These results are discussed in terms of potential involvement in the progression of this dementing disorder.

Why it matters

In brain tissue from four people with early Alzheimer's disease, eight proteins were found to be significantly nitrated in the inferior parietal lobule. This is a very small tissue study of possible disease mechanisms and does not show any treatment, cure or prevention.

Study details

Evidence strengthLow

How this study scored 43/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of cellular and molecular medicine)
Journal's citation record	2 / 4	Journal of Cellular and Molecular Medicine: journal h-index 187 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2009 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 136 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	7.2 citations a year over 19 year(s) since 2009
Impact for its field and year	3 / 6	Cited 5.8× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 8 other studies in this library
Still being cited	2 / 4	Cited 16 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author David Allan Butterfield: h-index 135 (OpenAlex, whole career)
Institution's track record	1 / 3	University of Kentucky: institution h-index 824 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 18752637)
Free to read	0 / 2	Behind a paywall — scores zero
Total	43 / 100	—

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