Newest studies

Exercise and cognition in older adults: is there a role for resistance training programmes?

55/100 ✓ Peer-reviewed Clinical safety British journal of sports medicine

Key finding: However, it has been suggested that other types of exercise training, such as resistance training, may also benefit cognition.

• Lifestyle
• Prevention

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Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease

40/100 ✓ Peer-reviewed Brain scans and imaging Journal of Lipid Research

Key finding: Overall, NPD1 promotes brain cell survival via the induction of antiapoptotic and neuroprotective gene-expression programs that suppress Abeta42 production and its neurotoxicity.

• Brain Biology

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Persistent delirium in older hospital patients: a systematic review of frequency and prognosis

78/100 ✓ Peer-reviewed Clinical safety Age and ageing

Key finding: We sought to determine the frequency and prognosis of persistent delirium (PerD) in older hospital patients by systematically reviewing original research on this topic. +2 more findings

• Care Services

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Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils

36/100 ✓ Peer-reviewed Risk factors Proceedings of the National Academy of Sciences of the United States of America

Key finding: We describe a full structural model for amyloid fibrils formed by the 40-residue beta-amyloid peptide associated with Alzheimer's disease (Abeta(1-40)), based on numerous constraints from solid state NMR and electron microscopy. +2 more findings

• Brain Biology

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Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels

41/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: Specifically, nascent BACE1 is transiently acetylated in seven lysine residues clustered in a highly disordered region of the protein that faces the lumen of the endoplasmic reticulum (ER)/ER Golgi intermediate compartment (ER/ERGIC). +3 more findings

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apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

55/100 ✓ Peer-reviewed Genetics The Journal of clinical investigation

Key finding: The APOE4 allele is a major risk factor for sporadic AD and has been associated with increased brain parenchymal and vascular amyloid burden. +1 more finding

• Genetics
• Brain Biology

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Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?

49/100 ✓ Peer-reviewed Cognitive tests and assessment Neuroscience letters

Key finding: Recent studies show that alpha-syn is present in CSF and possible to measure using enzyme-linked immunosorbent assay (ELISA). +3 more findings

• Biomarkers
• Brain Biology

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Aging and alpha-synuclein affect synaptic plasticity in the dentate gyrus

38/100 ✓ Peer-reviewed Disease mechanisms Journal of neural transmission (Vienna, Austria : 1996)

Key finding: We found decreased basal synaptic transmission and paired-pulse facilitation in the perforant path-dentate granule cell synapses of aged mice. +1 more finding

• Brain Biology

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The blood-brain barrier in brain homeostasis and neurological diseases

36/100 ✓ Peer-reviewed Vascular contributions Biochimica et biophysica acta

Key finding: Accumulating experimental and clinical evidence indicate that BBB dysfunctions are associated with a number of serious CNS diseases with important social impacts, such as multiple sclerosis, stroke, brain tumors, epilepsy or Alzheimer's disease.

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Lymphatic drainage of the brain and the pathophysiology of neurological disease

50/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica

Key finding: Cerebrospinal fluid drains via the cribriform plate and nasal mucosa to cervical lymph nodes in rats and sheep and to a lesser extent in humans. +3 more findings

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Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

54/100 ✓ Peer-reviewed Brain scans and imaging Archives of Neurology

Amyloid deposition can be identified among cognitively normal elderly persons during life, and the prevalence of asymptomatic amyloid deposition may be similar to that of symptomatic amyloid deposition.

• Brain Scans
• Diagnosis
• Early Stage

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Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome

38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Molecular & cellular proteomics : MCP

Key finding: Using isobaric tags for relative and absolute quantification, we found 52 proteins that differed in expression by greater than two standard deviations from the mean when an extra human chromosome 21 was present. +2 more findings

• Down Syndrome
• Brain Biology

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Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls

57/100 ✓ Peer-reviewed Cognitive tests and assessment NeuroImage

Key finding: In one of the largest brain mapping studies to date, we mapped the 3D profile of hippocampal degeneration over time in 490 subjects scanned twice with brain MRI over a 1-year interval (980 scans). +3 more findings

• Brain Scans
• Early Stage

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The COACH prompting system to assist older adults with dementia through handwashing: an efficacy study

50/100 ✓ Peer-reviewed Digital health tools BMC geriatrics

Key finding: The COACH system shows promise as a tool to help support older adults with moderate-levels of dementia and their caregivers. +2 more findings

• Digital Tools

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Effect of statins on a wide range of health outcomes: a cohort study validated by comparison with randomized trials

69/100 ✓ Peer-reviewed Brain scans and imaging British journal of clinical pharmacology

Key finding: We found little evidence to support wide-ranging effects of statins on health outcomes beyond their established beneficial effect on vascular disease. +3 more findings

• Clinical Trials

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MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1

45/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: Loss of specific miRNA control of gene expression is thus expected to underlie serious genetic diseases. +3 more findings

• Brain Biology
• Genetics

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Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: results from ADNI

53/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage

Key finding: MCI participants that converted to AD (average follow-up 15 months) displayed significantly lower volumes in a number of grey matter (GM) regions, as well as in the white matter (WM).

• Early Stage
• Brain Scans

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The Cochrane Database of Systematic Reviews – Issue 4 2008

45/100 ✓ Peer-reviewed Risk factors Journal of Evidence-Based Medicine

Key finding: More than 3500 Cochrane Reviews are now available in full, including information on the methods, eligible studies, analyses, results, and conclusions. +1 more finding

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Bright light therapy

38/100 ✓ Peer-reviewed Risk factors Neuro endocrinology letters

Key finding: Bright light is a treatment of choice for seasonal affective disorder. +3 more findings

• Treatments

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Glutamate and neurotrophic factors in neuronal plasticity and disease

36/100 ✓ Peer-reviewed Disease mechanisms Annals of the New York Academy of Sciences

Key finding: Neurotrophic factors and glutamate interact to regulate developmental and adult neuroplasticity. +4 more findings

• Brain Biology

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Lithium treatment and risk of dementia

64/100 ✓ Peer-reviewed Drug development Archives of general psychiatry

Key finding: Continued lithium treatment was associated with reduction of the rate of dementia to the same level as that for the general population. +2 more findings

• Treatments
• Risk Factors

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Status of computerized cognitive testing in aging: a systematic review

67/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: All test batteries exhibited some of the strengths of computerized cognitive testing: standardization of administration and stimulus presentation, accurate measures of response latencies, automated comparison in real time with an individual's prior performance as well as with age-related norms, and efficiencies of staffing and cost. +1 more finding

• Diagnosis
• Digital Tools

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Effects of prenatal alcohol exposure on hippocampal volume, verbal learning, and verbal and spatial recall in late childhood

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of the International Neuropsychological Society : JINS

Key finding: Given that the hippocampus is integral for the synthesis and retrieval of learned information and is particularly vulnerable to the teratogenic effects of alcohol, we assessed whether reduced learning and recall abilities in children with fetal alcohol spectrum disorders (FASDs) are associated with abnormal hippocampal volumes. +2 more findings

• Brain Scans
• Lifestyle

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Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb

48/100 ✓ Peer-reviewed Disease mechanisms Journal of neuropathology and experimental neurology

Key finding: These results indicate a high incidence of LBAS in the aging human OB; they also suggest that LBAS extends from the periphery to the anterior olfactory nucleus and results in clinical manifestations of LB disease.

• Brain Biology
• Other Dementias
• Risk Factors

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Prodromal Alzheimer's disease: successive emergence of the clinical symptoms

65/100 ✓ Peer-reviewed How common it is Annals of neurology

Key finding: This approach, describing the 14 years preceding dementia, provides a clear illustration of the particularly long and progressive prodromal phase of AD, and shows the successive emergence of cognitive deficits, depressive symptoms, and functional impairment during this phase. +1 more finding

• Early Stage

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