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Differential placental gene expression in severe preeclampsia
Sitras V, Paulssen RH, Grønaas H, Leirvik J, Hanssen TA, Vårtun A, Acharya G.. Placenta, 2009-02-26
Topic: Brain proteins, microglia and lab models
We investigated the global placental gene expression profile in severe preeclampsia. Twenty-one women were randomly selected from 50 participants with uncomplicated pregnancies to match 21 patients with severe preeclampsia. A 30K Human Genome Survey Microarray v.2.0 (Applied Biosystems) was used to evaluate the gene expression profile.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Sitras, V., Paulssen, R. H., Grønaas, H., Leirvik, J., Hanssen, T. A., Vårtun, A., et al. (2009). Differential placental gene expression in severe preeclampsia. Placenta. https://doi.org/10.1016/j.placenta.2009.01.012
Vancouver
Sitras V, Paulssen RH, Grønaas H, Leirvik J, Hanssen TA, Vårtun A, et al. Differential placental gene expression in severe preeclampsia. Placenta. 2009. doi:10.1016/j.placenta.2009.01.012. PMID: 19249095.
BibTeX
@article{sitras2009-19249095,
author = {Sitras, V. and Paulssen, R. H. and Grønaas, H. and Leirvik, J. and Hanssen, T. A. and Vårtun, A. and Acharya, G.},
title = {{Differential placental gene expression in severe preeclampsia}},
journal = {Placenta},
year = {2009},
doi = {10.1016/j.placenta.2009.01.012},
pmid = {19249095},
url = {https://doi.org/10.1016/j.placenta.2009.01.012}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Twenty-one women were randomly selected from 50 participants with uncomplicated pregnancies to match 21 patients with severe preeclampsia.
- A 30K Human Genome Survey Microarray v.2.0 (Applied Biosystems) was used to evaluate the gene expression profile.
- After RNA isolation, five preeclamptic placentas were excluded due to poor RNA quality.
- The series composed of 37 hybridizations in a one-channel detection system of chemiluminescence emitted by the microarrays.
Why it matters
This study compared placental gene expression between women with severe preeclampsia and uncomplicated pregnancies. It is about pregnancy complications and contains no information about treating, curing or preventing Alzheimer's disease.
Study details
- Participants50
- Effect sizeor=0.01
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Placenta) |
| Journal's citation record | 2 / 4 | Placenta: journal h-index 179 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 50 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 285 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 15.0 citations a year over 19 year(s) since 2009 |
| Impact for its field and year | 5 / 6 | Cited 24.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 33 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Ganesh Acharya: h-index 51 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | UiT The Arctic University of Norway: institution h-index 655 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 19249095) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
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