Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 21,526–21,550 of 27,380 studies, newest first · page 862 of 1096.
April 2009 15
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2009-04-01
Dysphagia in patients with dementia: Alzheimer versus vascular
36/100 ✓ Peer-reviewed Clinical safety Alzheimer disease and associated disorders
Key finding: The results indicate that there are some different patterns of swallowing disorders. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-04-01
Cognitive training in older adults with Mild Cognitive Impairment: Impact on cognitive and functional performance
40/100 ✓ Peer-reviewed Prevention trials Dementia & neuropsychologia
Key finding: Aging is associated with cognitive decline, yet this does not prevent older adults from finding ways to compensate for age-related deficits. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-04-01
Neurodegenerative Diseases Target Large-Scale Human Brain Networks
58/100 ✓ Peer-reviewed Brain scans and imaging Neuron
Key finding: Five different neurodegenerative syndromes cause circumscribed atrophy within five distinct, healthy, human intrinsic functional connectivity networks. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-04-01
Activation of microglia by amyloid {beta} requires P2X7 receptor expression
46/100 ✓ Peer-reviewed Inflammation and the immune system Journal of immunology (Baltimore, Md. : 1950)
Key finding: Release of this and other nucleotides modulates microglia responses via P2Y and P2X receptors, among which the P2X(7) subtype stands out for its proinflammatory activity and for up-regulation in a transgenic model of Alzheimer disease and in brains from Alzheimer disease patients. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-04-01
TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration
54/100 ✓ Peer-reviewed Brain tissue and pathology Annals of neurology
Key finding: Mutations in TARDBP gene, coding for TDP-43, were found in patients with pure MND. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-04-01
Genetic control of human brain transcript expression in Alzheimer disease
57/100 ✓ Peer-reviewed Brain tissue and pathology American journal of human genetics
Key finding: We have now analyzed additional samples with a confirmed pathologic diagnosis of late-onset Alzheimer disease (LOAD; final n = 188 controls, 176 cases). +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-04-01
Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS
49/100 ✓ Peer-reviewed Mild cognitive impairment Neurology
Key finding: Seventy-five subjects with MCI progressed to dementia by last follow-up. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-04-01
Alzheimer's disease neuroimaging initiative: a one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition
63/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage
Key finding: Voxelwise statistical analyses revealed regional differences in atrophy rates, and these differences were correlated with clinical measures and biomarkers. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-04-01
A systemic review of the roles of n-3 fatty acids in health and disease
56/100 ✓ Peer-reviewed Risk factors Journal of the American Dietetic Association
Key finding: Furthermore, additional controlled clinical trials are needed to document whether long-term consumption or supplementation with eicosapentaenoic acid/docosahexaenoic acid or the plant-derived counterpart (alpha-linolenic acid) results in better quality of life.
Full summary, score breakdown and related studies → Original source
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2009-04-01
The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery
62/100 ✓ Peer-reviewed Disparities Alzheimer disease and associated disorders
Key finding: The results demonstrate performance on tests sensitive to cognitive aging and to the early stages of Alzheimer disease in a relatively well-educated sample. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-04-01
Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy
55/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: MRI evidence of small subacute infarcts is present in a substantial proportion of living patients with advanced cerebral amyloid angiopathy (CAA). +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-04-01
Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus
74/100 ✓ Peer-reviewed Getting a diagnosis JAMA
Key finding: Among older patients with type 2 diabetes, a history of severe hypoglycemic episodes was associated with a greater risk of dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-04-01
Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles
53/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Discovery efforts for susceptibility loci for Alzheimer disease could benefit from the use of neuropathologic intermediate phenotypes as a complement to other approaches. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-04-01
A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease
67/100 ✓ Peer-reviewed Genetics Aging clinical and experimental research
Key finding: Ibuprofen, if used for relatively short periods of time and although well tolerated thanks to gastroprotection, does not seem to be effective in tertiary prevention of mild-moderate AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-04-01
Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease
46/100 ✓ Peer-reviewed Genetics Neurology
Key finding: These results indicate that the epsilon4-positive APOE genotype not only represents a risk factor for Alzheimer disease (AD), but also results in higher levels of Abeta plaque deposition in epsilon4-positive patients with AD compared to age-matched epsilon4-negative patients with similar levels of cognitive impairment and brain atrophy. +4 more findings
Full summary, score breakdown and related studies → Original source
March 2009 10
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2009-03-31
Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers
43/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Regulated proteolysis of APP generates biologically active fragments such as the neuroprotective secreted ectodomain sAPPalpha and the neurotoxic beta-amyloid peptide. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-31
Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease
75/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology
Key finding: The purpose of this study was to use serial imaging to gain insight into the sequence of pathologic events in Alzheimer's disease, and the clinical features associated with this sequence. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-31
The retina in Parkinson's disease
52/100 ✓ Peer-reviewed Risk factors Brain : a journal of neurology
Key finding: In addition, visual symptoms are common, ranging from complaints of dry eyes and reading difficulties, through to perceptual disturbances (feelings of presence and passage) and complex visual hallucinations. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-26
The dopamine hypothesis of schizophrenia: version III--the final common pathway
55/100 ✓ Peer-reviewed Lewy body dementia Schizophrenia bulletin
Key finding: This hypothesis seeks to be comprehensive in providing a framework that links risk factors, including pregnancy and obstetric complications, stress and trauma, drug use, and genes, to increased presynaptic striatal dopaminergic function. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-25
Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
53/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica
Key finding: Recent data from brain imaging studies in humans and animal models suggest that cerebrovascular dysfunction may precede cognitive decline and onset of neurodegenerative changes in AD and AD models. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-25
Validity of the CogState brief battery: relationship to standardized tests and sensitivity to cognitive impairment in mild traumatic brain injury, schizophrenia, and AIDS dementia complex
49/100 ✓ Peer-reviewed Getting a diagnosis Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
Key finding: Taken together, the results suggest that the cognitive paradigms operationally defined in the CogState brief battery have acceptable construct and criterion validity in a neuropsychological context.
Full summary, score breakdown and related studies → Original source
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2009-03-24
Image-driven population analysis through mixture modeling
43/100 ✓ Peer-reviewed Digital health tools IEEE transactions on medical imaging
Key finding: Our analysis suggests that these subgroups mainly correspond to age groups. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-24
Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study
53/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology
Key finding: In this population sample, which includes the full ageing spectrum from individuals with no cognitive impairment to those with dementia satisfying clinico-pathology criteria for Alzheimer's disease, we have demonstrated a high prevalence at death of tau pathology. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-03-24
Mild behavioral impairment and risk of dementia: a prospective cohort study of 358 patients
46/100 ✓ Peer-reviewed Prevention and risk The Journal of clinical psychiatry
Key finding: Thirty-four percent of MCI patients and over 70% of patients with MBI developed dementia (log-rank p = .011). +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-21
Exposure to enriched environment restores the survival and differentiation of new born cells in the hippocampus and ameliorates depressive symptoms in chronically stressed rats
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuroscience letters
Key finding: Recently, we demonstrated that EE following restraint stress restores cell proliferation in the dentate gyrus (DG), hippocampal volume and learning. +2 more findings
Full summary, score breakdown and related studies → Original source
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