Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,901–20,925 of 27,380 studies, newest first · page 837 of 1096.
March 2010 25
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2010-03-24
Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)
49/100 ✓ Peer-reviewed Brain tissue and pathology PloS one
Key finding: Amyotrophic lateral sclerosis (ALS), a common late-onset neurodegenerative disease, is associated with fronto-temporal dementia (FTD) in 3-10% of patients. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-23
High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment
36/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage
Key finding: We found that patients showed impaired performance on trials that taxed their pattern separation abilities. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-22
Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America
Key finding: These channels allow calcium uptake in amyloid precursor protein-deficient cells. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-21
Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders
58/100 ✓ Peer-reviewed Lewy body dementia Acta neuropathologica
Key finding: The frequency of PASH within other organs and tissue types was much lower. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-21
Factors determining the impact of care-giving on caregivers of elderly patients with dementia. A systematic literature review
52/100 ✓ Peer-reviewed Caregiving Maturitas
Key finding: Caregiver characteristics rather than objective care needs of the patients tend to be responsible for the onset of depression. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-03-19
Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008
52/100 ✓ Peer-reviewed Prevention trials Nutrition, metabolism, and cardiovascular diseases : NMCD
Key finding: Increasing evidence suggests that monounsaturated fatty acids (MUFA) as a nutrient, OO as a food, and the MedDiet as a food pattern are associated with a decreased risk of cardiovascular disease, obesity, metabolic syndrome, type 2 diabetes and hypertension. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-19
Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure
70/100 ✓ Peer-reviewed Risk factors Hypertension (Dallas, Tex. : 1979)
Key finding: Participants on the DASH diet combined with a behavioral weight management program exhibited greater improvements in executive function-memory-learning (Cohen's D=0.562; P=0.008) and psychomotor speed (Cohen's D=0.480; P=0.023), and DASH diet alone participants exhibited better psychomotor speed (Cohen's D=0.440; P=0.036) compared with the usual diet control. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-03-16
Microglia in neurodegenerative disease
51/100 ✓ Peer-reviewed Inflammation and the immune system Nature reviews. Neurology
Key finding: Morphologically activated microglia, like other tissue macrophages, exist as many different phenotypes, depending on the nature of the tissue injury. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-16
TAR DNA-binding protein 43 in neurodegenerative disease
49/100 ✓ Peer-reviewed Lewy body dementia Nature reviews. Neurology
Key finding: Since then, rapid advances have been made in our understanding of the physiological function of TDP-43 and the role of this protein in neurodegeneration. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-15
Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes
40/100 ✓ Peer-reviewed Vascular contributions Proceedings of the National Academy of Sciences
Key finding: Recent epidemiological studies suggest that diabetes mellitus is a strong risk factor for Alzheimer disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-15
Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease
36/100 ✓ Peer-reviewed Brain scans and imaging Proceedings of the National Academy of Sciences of the United States of America
Key finding: Our previous analyses showed that allopregnanolone (APalpha) significantly increased proliferation of rodent and human neural progenitor cells in vitro. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-15
Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease
47/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage
Key finding: Comparing MCI subgroups (reverters, stable and converters): volumes were lower and rates higher in converters compared with stable and reverter groups (p< or =0.03). +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-03-15
The death knoll for the MMSE: has it outlived its purpose?
39/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of geriatric psychiatry and neurology
Key finding: Originally designed to assess cognitive impairment in elderly populations, it has become one of the first steps toward a dementia diagnosis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-12
Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases
45/100 ✓ Peer-reviewed Inflammation and the immune system FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Key finding: The effect is correlated with activation of the inflammatory pathways P38 MAP- kinase, Jun-N-terminal kinase, and NF-kappaB. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-11
Promoting Successful Cognitive Aging: A Comprehensive Review
59/100 ✓ Peer-reviewed Drug development Journal of Alzheimer s Disease
Key finding: Currently, lines of converging evidence allow the strongest case to be made for physical and cognitively stimulating activities. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-10
People with dementia living alone: what are their needs and what kind of support are they receiving?
51/100 ✓ Peer-reviewed Prevention and risk International psychogeriatrics
Key finding: This study illustrates the need to identify these individuals and to make provisions among social service agencies to monitor their well-being regularly and provide a higher level of support when needs are identified. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-09
Daytime sleepiness is associated with dementia and cognitive decline in older Italian adults: a population-based study
44/100 ✓ Peer-reviewed Cognitive tests and assessment Sleep medicine
Key finding: The occurrence of dementia among the elderly has been associated with several, often not modifiable, risk factors. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-09
The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases
49/100 ✓ Peer-reviewed Risk factors Journal of biomedicine & biotechnology
Key finding: Evidence suggests that the protective effect of exercise may to some extent be ascribed to the antiinflammatory effect of regular exercise. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-08
Entering and Exiting the Medicare Part D Coverage Gap: Role of Comorbidities and Demographics
50/100 ✓ Peer-reviewed Health systems and care delivery Journal of General Internal Medicine
Key finding: Of enrollees, 15.9% entered the gap, 2.6% within the first 180 days; among gap enterers, only 6.7% exited again. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-04
Prevalence of dementia disorders in the oldest-old: an autopsy study
53/100 ✓ Peer-reviewed Cognitive tests and assessment Acta neuropathologica
Key finding: A retrospective hospital-based study of the relative prevalence of different disorders was performed in 1,110 consecutive autopsy cases of demented elderly in Vienna, Austria (66% females, MMSE <20; mean age 83.3 +/- 5.4 SD years). +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-03
Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe
76/100 ✓ Peer-reviewed Treatments Neurology
Key finding: In this large-scale randomized controlled trial evaluating statin therapy as a treatment for mild to moderate Alzheimer disease, atorvastatin was not associated with significant clinical benefit over 72 weeks. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-02
Occlusion and brain function: mastication as a prevention of cognitive dysfunction
41/100 ✓ Peer-reviewed Prevention and risk Journal of oral rehabilitation
Key finding: Research in animals and humans has shown that mastication maintains cognitive function in the hippocampus, a brain area important for learning and memory. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-03 month only
Metabolic syndrome and risk of dementia in older adults
55/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society
Key finding: Risk of overall dementia and its subtypes was not associated with MetS or any MetS component in participants younger than 75. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-03 month only
Galantamine for Alzheimer's disease
66/100 ✓ Peer-reviewed Treatments Expert opinion on drug metabolism & toxicology
Key finding: OF THE FIELD: Alzheimer's disease (AD) is the most frequent, age-related neurodegenerative disorder and is characterized by progressive deterioration of cognition and global functioning.
Full summary, score breakdown and related studies → Original source
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2010-03-01
Acetylcholinesterase inhibitors and memantine for neuroenhancement in healthy individuals: a systematic review
66/100 ✓ Peer-reviewed Treatments Pharmacological research
Key finding: Based on a systematic review we found that expectations about the potential of these drugs exceed their actual effects, as has been demonstrated in randomised controlled trials. +1 more finding
Full summary, score breakdown and related studies → Original source
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