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Neurodegenerative Diseases Target Large-Scale Human Brain Networks
William W. Seeley, Richard K. Crawford, Juan Helen Zhou, Bruce L. Miller, Michael D. Greicius. Neuron, 2009-04-01
Topic: Amyloid, tau and blood-test diagnosis
The study used network-sensitive neuroimaging methods to test whether neurodegenerative diseases target large-scale neural networks in living humans. The researchers found that five distinct neurodegenerative syndromes cause circumscribed atrophy within five distinct healthy intrinsic functional connectivity networks. Additionally, they discovered that nodes within each functional network exhibited tightly correlated gray matter volumes across healthy individuals.
Key findings
- Five different neurodegenerative syndromes cause circumscribed atrophy within five distinct, healthy, human intrinsic functional connectivity networks.
- Across healthy individuals, nodes within each functional network exhibited tightly correlated gray matter volumes.
- The findings suggest that human neural networks can be defined by synchronous baseline activity, a unified corticotrophic fate, and selective vulnerability to neurodegenerative illness.
Why it matters
Reports that neurodegenerative diseases target large-scale human brain networks.
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How this study scored 58/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 55 of the 95 points we could judge it on, which is 58 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neuron) |
| Journal's citation record | 4 / 4 | Neuron: journal h-index 689 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 2,363 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 124.4 citations a year over 19 year(s) since 2009 |
| Impact for its field and year | 6 / 6 | Cited 49.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 4 / 4 | Cited 383 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Michael D. Greicius: h-index 65 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Stanford University: institution h-index 2,684 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 19376066) |
| Free to read | 2 / 2 | Free to read |
| Points | 55 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 55 of the 95 points we could judge it on is 58 out of 100. |
| Total | 58 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Seeley, W. W., Crawford, R. K., Zhou, J. H., Miller, B. L., & Greicius, M. D. (2009). Neurodegenerative Diseases Target Large-Scale Human Brain Networks. Neuron. https://doi.org/10.1016/j.neuron.2009.03.024
Vancouver
Seeley WW, Crawford RK, Zhou JH, Miller BL, Greicius MD. Neurodegenerative Diseases Target Large-Scale Human Brain Networks. Neuron. 2009. doi:10.1016/j.neuron.2009.03.024. PMID: 19376066.
BibTeX
@article{seeley2009-19376066,
author = {Seeley, William W. and Crawford, Richard K. and Zhou, Juan Helen and Miller, Bruce L. and Greicius, Michael D.},
title = {{Neurodegenerative Diseases Target Large-Scale Human Brain Networks}},
journal = {Neuron},
year = {2009},
doi = {10.1016/j.neuron.2009.03.024},
pmid = {19376066},
url = {https://doi.org/10.1016/j.neuron.2009.03.024}
}
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