Newest studies

Examination of cognitive and instrumental functional performance as indicators for driving cessation risk across 3 years

52/100 ✓ Peer-reviewed Prevention trials The Gerontologist

Key finding: We used Cox proportional hazard analyses to examine prospective predictors of driving cessation over a 3-year period. +1 more finding

Full summary, score breakdown and related studies → Original source

The effects of an engaged lifestyle on cognitive vitality: a field experiment

62/100 ✓ Peer-reviewed Prevention trials Psychology and aging

Key finding: Experimental studies on cognitive training have suggested that the effects of experience are narrow in augmenting or maintaining cognitive abilities, while correlational studies report a wide range of benefits of an engaged lifestyle, including increased longevity, resistance to dementia, and enhanced cognitive flexibility.

• Lifestyle

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Can training in a real-time strategy video game attenuate cognitive decline in older adults?

66/100 ✓ Peer-reviewed Prevention trials Psychology and aging

Key finding: The trainees improved significantly in the measures of game performance. +1 more finding

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Spouses' Effectiveness as End-of-Life Health Care Surrogates: Accuracy, Uncertainty, and Errors of Overtreatment or Undertreatment

50/100 ✓ Peer-reviewed Health systems and care delivery The Gerontologist

Key finding: Surrogates were accurate in the majority of cases, made errors in 12% to 22% of cases, and were uncertain in 11% to 16% of cases. +3 more findings

• Caregiving
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease

45/100 ✓ Peer-reviewed Brain tissue and pathology Journal of neuropathology and experimental neurology

Key finding: Transactivation-responsive DNA-binding protein 43-immunostained inclusions have also been found in other neurodegenerative disorders including Alzheimer disease, dementia with Lewy bodies, and parkinsonism dementia complex of Guam. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

[CSF levels of total tau protein in patients with mild cognitive impairment and Alzheimer's disease]

33/100 ✓ Peer-reviewed Tau biomarkers Zeitschrift fur Gerontologie und Geriatrie

Key finding: Tau protein was therefore regarded as a putative molecular marker for AD. +3 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Docosahexaenoic acid and the aging brain

42/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of nutrition

Key finding: Recent studies underscore the importance of DHA-derived neuroprotectin D1 (NPD1) in the homeostatic regulation of brain cell survival and repair involving neurotrophic, antiapoptotic and antiinflammatory signaling. +3 more findings

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Temporal trends in the long term risk of progression of mild cognitive impairment: a pooled analysis

55/100 ✓ Peer-reviewed Mild cognitive impairment Journal of neurology, neurosurgery, and psychiatry

Key finding: A 10-15% ACR only appears to hold true in clinical samples monitored over a short observation period. +3 more findings

• Early Stage

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Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease

51/100 ✓ Peer-reviewed Mild cognitive impairment Annals of the New York Academy of Sciences

Key finding: Increasing evidence suggests that CMRglc reductions occur at the preclinical stages of AD. +1 more finding

• Early Stage
• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

Setting a public health research agenda for Down syndrome: summary of a meeting sponsored by the Centers for Disease Control and Prevention and the National Down Syndrome Society

47/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of medical genetics. Part A

Key finding: Participants included experts in clinical and molecular genetics, pediatrics, cardiology, psychiatry, psychology, neuroscience, epidemiology, and public health. +4 more findings

• Down Syndrome
• Prevention

Full summary, score breakdown and related studies → Original source

Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows

49/100 ✓ Peer-reviewed Risk factors Annals of the New York Academy of Sciences

Key finding: Alzheimer's disease (AD) is the most common form of neurodegenerative disease associated with dementia in the elderly. +4 more findings

• Clinical Trials
• Brain Biology

Full summary, score breakdown and related studies → Original source

Apraxia of speech and nonfluent aphasia: a new clinical marker for corticobasal degeneration and progressive supranuclear palsy

46/100 ✓ Peer-reviewed Digital health tools Current opinion in neurology

Key finding: Recent findings Corticobasal degeneration and PSP are neurodegenerative diseases characterized by neuronal loss and gliosis in cardinal brain regions, as well as the abnormal deposition of the microtubule associated protein tau in cell bodies and cell processes. +1 more finding

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Methods for estimating prevalence ratios in cross-sectional studies

53/100 ✓ Peer-reviewed How common it is Revista de saude publica

Key finding: In analyses of data from cross-sectional studies, the Cox and Poisson models with robust variance are better alternatives than logistic regression is.

Full summary, score breakdown and related studies → Original source

Effectiveness of Cognitive/Behavioral Small Group Intervention for Reduction of Depression and Stress in Non-Hispanic White and Hispanic/Latino Women Dementia Family Caregivers: Outcomes and Mediators of Change

49/100 ✓ Peer-reviewed Disparities Journal of rational-emotive and cognitive-behavior therapy : RET

Key finding: This study enrolled 184 middle-aged and older women (95 Non-Hispanic White and 89 Hispanic/Latino) who provided in-home hands-on care to an elderly relative with Alzheimer's disease or another form of dementia. +3 more findings

• Health Equity
• Caregiving

Full summary, score breakdown and related studies → Original source

Recovery of activities of daily living in older adults after hospitalization for acute medical illness

50/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society

Key finding: By 12 months after discharge, of those discharged with new or additional ADL disability, 41.3% died, 28.6% were alive but had not recovered to baseline function, and 30.1% were at baseline function. +1 more finding

• Care Services

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Hippocampal volumes, proton magnetic resonance spectroscopy metabolites, and cerebrovascular disease in mild cognitive impairment subtypes

53/100 ✓ Peer-reviewed Brain scans and imaging Archives of neurology

Key finding: The MRI and 1H MRS findings in single-domain aMCI are consistent with a pattern similar to that of Alzheimer disease. +2 more findings

• Brain Scans
• Early Stage

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Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease

53/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Medial temporal lobe atrophy (MTA) scores 1) distinguish probable Alzheimer disease (AD) and amnestic mild cognitive impairment (MCI) subjects from nonamnestic MCI and no cognitive impairment (NCI) subjects, 2) help predict diagnosis at baseline, and 3) predict transition from NCI to MCI and from MCI to probable AD.

• Brain Scans
• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Falls: epidemiology, pathophysiology, and relationship to fracture

42/100 ✓ Peer-reviewed Prevention and risk Current osteoporosis reports

Key finding: Falls are common in the elderly, and frequently result in injury and disability. +3 more findings

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Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects

61/100 ✓ Peer-reviewed How common it is Brain : a journal of neurology

Key finding: In BAC NC, elevated PIB uptake was significantly associated with smaller aHV (P = 0.0016) and worse EM (P = 0.0086). +4 more findings

• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

Gait capacity affects cortical activation patterns related to speed control in the elderly

36/100 ✓ Peer-reviewed Digital health tools Experimental brain research

Key finding: We examined whether cortical activation patterns associated with the control of gait speed were related to the walking capacity in elderly subjects. +2 more findings

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Amygdala volume marks the acute state in the early course of depression

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry

Key finding: A state related increase of amygdala volume can be detected early in the course of MDD.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Can voxel based morphometry, manual segmentation and automated segmentation equally detect hippocampal volume differences in acute depression?

67/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage

Key finding: Using VBM-DARTEL, when corrected for multiple comparisons, significant volume differences were detected between groups in different regions and more specifically in hippocampus with ROI analyses. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease

36/100 ✓ Peer-reviewed Clinical safety Neurobiology of aging

Key finding: No significant differences were found between MCI-DLB and MCI-AD cases in age at death, gender, ApoE status, education, time followed while clinically normal, or duration of MCI. +2 more findings

• Early Stage
• Other Dementias
• Diagnosis

Full summary, score breakdown and related studies → Original source

Cognitive impairment in incident, untreated Parkinson disease: the Norwegian ParkWest study

55/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: The findings demonstrate a twofold increase in the proportion with cognitive impairment in subjects with early, untreated Parkinson disease (PD) compared to controls. +3 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studies

36/100 ✓ Peer-reviewed Vascular contributions Alcoholism, clinical and experimental research

Key finding: A considerable body of epidemiology associates moderate alcohol consumption with significantly reduced risks of coronary heart disease and, albeit currently a less robust relationship, cerebrovascular (ischemic) stroke. +3 more findings

• Brain Biology
• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source