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Classification and basic pathology of Alzheimer disease
Duyckaerts C, Delatour B, Potier MC.. Acta neuropathologica, 2009-04-21
Topic: Amyloid, tau and blood-test diagnosis
The lesions of Alzheimer disease include accumulation of proteins, losses of neurons and synapses, and alterations related to reactive processes. Extracellular Abeta accumulation occurs in the parenchyma as diffuse, focal or stellate deposits. It may involve the vessel walls of arteries, veins and capillaries.
Key findings
- Extracellular Abeta accumulation occurs in the parenchyma as diffuse, focal or stellate deposits.
- It may involve the vessel walls of arteries, veins and capillaries.
- The cases in which the capillary vessel walls are affected have a higher probability of having one or two apoepsilon 4 alleles.
- Parenchymal as well as vascular Abeta deposition follows a stepwise progression.
Why it matters
This pathology review describes the brain lesions of Alzheimer's disease, including extracellular amyloid-beta deposits in tissue and blood vessel walls, and notes that cases with affected capillary walls are more likely to have one or two apolipoprotein E epsilon 4 alleles. It is a descriptive classification of disease pathology and reports no treatment, cure or prevention.
Study details
- Evidence strengthLow
How this study scored 58/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Acta neuropathologica) |
| Journal's citation record | 3 / 4 | Acta Neuropathologica: journal h-index 287 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,030 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 54.2 citations a year over 19 year(s) since 2009 |
| Impact for its field and year | 5 / 6 | Cited 36.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 32 other studies in this library |
| Still being cited | 3 / 4 | Cited 142 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Marie‐Claude Potier: h-index 52 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Centre National de la Recherche Scientifique: institution h-index 2,511 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 19381658) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 58 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Duyckaerts, C., Delatour, B., & Potier, M. C. (2009). Classification and basic pathology of Alzheimer disease. Acta neuropathologica. https://doi.org/10.1007/s00401-009-0532-1
Vancouver
Duyckaerts C, Delatour B, Potier MC. Classification and basic pathology of Alzheimer disease. Acta neuropathologica. 2009. doi:10.1007/s00401-009-0532-1. PMID: 19381658.
BibTeX
@article{duyckaerts2009-19381658,
author = {Duyckaerts, C. and Delatour, B. and Potier, M. C.},
title = {{Classification and basic pathology of Alzheimer disease}},
journal = {Acta neuropathologica},
year = {2009},
doi = {10.1007/s00401-009-0532-1},
pmid = {19381658},
url = {https://doi.org/10.1007/s00401-009-0532-1}
}
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