Newest studies

Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies

51/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica

Key finding: Intracellular accumulation of TDP-43 is observed in a subpopulation of patients with other dementia disorders, including Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). +3 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease

40/100 ✓ Peer-reviewed Genetics Nature genetics

Key finding: By analyzing late-onset Alzheimer's disease (LOAD) in a genome-wide association study (313,504 SNPs, three series, 844 cases and 1,255 controls) and evaluating the 25 SNPs with the most significant allelic association in four additional series (1,547 cases and 1,209 controls), we identified a SNP (rs5984894) on Xq21.3 in PCDH11X that is strongly associated with LOAD in individuals of European descent from the United States. +2 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Natural history of feeding-tube use in nursing home residents with advanced dementia

40/100 ✓ Peer-reviewed Clinical safety Journal of the American Medical Directors Association

Key finding: Most feeding tubes are inserted in an acute care hospital. +3 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial

78/100 ✓ Peer-reviewed Clinical trials The Lancet. Neurology

Key finding: We aimed to assess whether continued treatment with antipsychotics in people with AD is associated with an increased risk of mortality. +4 more findings

• Clinical Trials
• Side Effects

Full summary, score breakdown and related studies → Original source

Kynurenine pathway metabolites in humans: disease and healthy States

40/100 ✓ Peer-reviewed Tau biomarkers International journal of tryptophan research : IJTR

Key finding: The kynurenine pathway has been demonstrated to be involved in many diseases and disorders, including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, AIDS dementia complex, malaria, cancer, depression and schizophrenia, where imbalances in tryptophan and kynurenines have been found.

Full summary, score breakdown and related studies → Original source

Diabetes and the risk of multi-system aging phenotypes: a systematic review and meta-analysis

62/100 ✓ Peer-reviewed Risk factors PloS one

Key finding: Current evidence supports that DM is associated with increased risk for selected geriatric conditions. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Examination of the current top candidate genes for AD in a genome-wide association study

54/100 ✓ Peer-reviewed Genetics Molecular psychiatry

Key finding: We present our GWAS results from the German population for genes included in the 'Top Results' list on the AlzGene database website. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Upregulation of BACE1 and beta-amyloid protein mediated by chronic cerebral hypoperfusion contributes to cognitive impairment and pathogenesis of Alzheimer's disease

37/100 ✓ Peer-reviewed Risk genes beyond APOE Neurochemical research

Key finding: To investigate expression of APP, BACE1 and A beta in the hippocampus of BCCAO rats and study pathophysiological mechanism of AD from CCH. +3 more findings

Full summary, score breakdown and related studies → Original source

Self-perceptions of aging predict mortality and change with approaching death: 16-year longitudinal results from the Berlin Aging Study

60/100 ✓ Peer-reviewed Disparities Psychology and Aging

Key finding: Extending previous studies, they found that it is not only higher aging satisfaction and younger subjective age but also more favorable change patterns (e.g., less decline in aging satisfaction) that are uniquely associated with lower mortality hazards.

Full summary, score breakdown and related studies → Original source

Racial differences in knowledge and beliefs about Alzheimer disease

46/100 ✓ Peer-reviewed Disparities Alzheimer disease and associated disorders

Key finding: Alzheimer disease (AD) is a growing public health problem that disproportionately affects racial and ethnic minorities, including African Americans. +1 more finding

• Health Equity

Full summary, score breakdown and related studies → Original source

Evidence-based long term care design

38/100 ✓ Peer-reviewed Health systems and care delivery NeuroRehabilitation

Key finding: Research on the impact of the built environment in long-term care settings continues to grow. +2 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Amyloid-beta42 plasma levels are elevated in amnestic mild cognitive impairment

50/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD

Key finding: In the total cohort of aMCI cases, the average level of Abeta42, as well as the Abeta42/Abeta40 ratio, was significantly higher than those of the 102 cognitively normal age-matched subjects. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study

60/100 ✓ Peer-reviewed End-of-life care Journal of Alzheimer's disease : JAD

Key finding: Key neuropathological changes associated with late-onset dementia are not fully understood. +2 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Biological and chemical approaches to diseases of proteostasis deficiency

36/100 ✓ Peer-reviewed Disease mechanisms Annual review of biochemistry

Key finding: Proteostasis is maintained by the proteostasis network, which comprises pathways that control protein synthesis, folding, trafficking, aggregation, disaggregation, and degradation. +4 more findings

Full summary, score breakdown and related studies → Original source

Mammalian nicotinic acetylcholine receptors: from structure to function

36/100 ✓ Peer-reviewed Brain tissue and pathology Physiological reviews

Key finding: This review provides a comprehensive overview of these findings and the more recent revelations of the impact that the rich diversity in function and expression of this receptor family has on neuronal and nonneuronal cells throughout the body.

Full summary, score breakdown and related studies → Original source

Akt/GSK3 signaling in the action of psychotropic drugs

36/100 ✓ Peer-reviewed Drug development Annual review of pharmacology and toxicology

Key finding: Psychotropic drugs acting on monoamine neurotransmission are major pharmacological treatments for neuropsychiatric conditions such as schizophrenia, depression, bipolar disorder, Tourette syndrome, ADHD, and Alzheimer disease. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease

55/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Efforts to use plasma levels of Abeta peptides as AD biomarkers or disease-staging scales have failed. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Development of tau aggregation inhibitors for Alzheimer's disease

36/100 ✓ Peer-reviewed Drug development Angewandte Chemie (International ed. in English)

Key finding: Highly organized protein aggregates, called amyloid fibrils, and aggregation intermediates are observed; these are considered to be mediators of cellular toxicity and thus attract a great deal of attention from investigators. +4 more findings

• Treatments
• Brain Biology
• Clinical Trials

Full summary, score breakdown and related studies → Original source

MR tractography: a review of its clinical applications

36/100 ✓ Peer-reviewed Vascular contributions Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine

Key finding: Magnetic resonance tractography based on diffusion-tensor imaging was first introduced to the medical imaging community a decade ago. +4 more findings

Full summary, score breakdown and related studies → Original source

Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI Study

74/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology

Key finding: Conjugated equine estrogens with or without MPA are associated with greater brain atrophy among women aged 65 years and older; however, the adverse effects are most evident in women experiencing cognitive deficits before initiating hormone therapy. +2 more findings

• Brain Scans
• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder

57/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of psychiatry & neuroscience : JPN

Key finding: Although all studies were cross-sectional, our results suggest that hippocampal volume reductions generally occur after disease onset in patients with MDD. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Discomfort in dementia patients dying from pneumonia and its relief by antibiotics

45/100 ✓ Peer-reviewed End-of-life care Scandinavian journal of infectious diseases

Key finding: Compared with discomfort in patients with intake problems, unadjusted and adjusted discomfort in patients with pneumonia was higher both at t 0 and before death. +1 more finding

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Persistent delirium predicts greater mortality

52/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society

Key finding: In patients who were delirious at the time of PAC admission, persistent delirium was a significant independent predictor of 1-year mortality. +2 more findings

Full summary, score breakdown and related studies → Original source

Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population

66/100 ✓ Peer-reviewed Clinical safety Critical care medicine

Key finding: The use of benzodiazepines or opioids in the ICU is associated with longer duration of a first episode of delirium. +4 more findings

• Side Effects

Full summary, score breakdown and related studies → Original source

Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons

36/100 ✓ Peer-reviewed Disease mechanisms Journal of Alzheimer's disease : JAD

Key finding: Recently, we have demonstrated enhanced hippocampal neurogenesis by oral administration of Ginkgo biloba extract (EGb 761) to a mouse model of AD. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source