Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,926–20,950 of 27,380 studies, newest first · page 838 of 1096.
March 2010 23
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2010-03-01
Effect of a purpose in life on risk of incident Alzheimer disease and mild cognitive impairment in community-dwelling older persons
64/100 ✓ Peer-reviewed Long-term cohort studies Archives of general psychiatry
Key finding: Greater purpose in life is associated with a reduced risk of AD and MCI in community-dwelling older persons. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-01
Neural mechanisms of ageing and cognitive decline
41/100 ✓ Peer-reviewed How common it is Nature
Key finding: During the past century, treatments for the diseases of youth and middle age have helped raise life expectancy significantly.
Full summary, score breakdown and related studies → Original source
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2010-03-01
Comfort feeding only: a proposal to bring clarity to decision-making regarding difficulty with eating for persons with advanced dementia
36/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: The existing evidence based on observational studies suggests that feeding tubes do not improve survival or reduce the risk of aspiration, yet the use of feeding tubes is prevalent in patients with dementia, and the majority of nursing home residents do not have orders documenting their wishes about the use of artificial hydration and nutrition.
Full summary, score breakdown and related studies → Original source
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2010-03-01
The worldwide societal costs of dementia: Estimates for 2009
43/100 ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The worldwide cost of dementia has increased by 34% (18% in fixed prices) between 2005 and 2009. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-03-01
Mechanisms underlying inflammation in neurodegeneration
36/100 ✓ Peer-reviewed Inflammation and the immune system Cell
Key finding: Inflammation is associated with many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-03-01
Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease
43/100 ✓ Peer-reviewed Treatments Clinical neuropharmacology
Key finding: A single dose of solanezumab was generally well tolerated, although infusion reactions similar to those seen with administration of other proteins may occur with higher doses. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-03-01
Functional alterations in memory networks in early Alzheimer's disease
36/100 ✓ Peer-reviewed Brain scans and imaging Neuromolecular medicine
Key finding: Recent functional imaging studies suggest that memory function is subserved by a set of distributed networks, which include both the medial temporal lobe (MTL) system and the set of cortical regions collectively referred to as the default network. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-01
Relationship between atrophy and beta-amyloid deposition in Alzheimer disease
47/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology
Key finding: There is a strong relationship between beta-amyloid deposition and atrophy very early in the disease process. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-03-01
Cognition, reserve, and amyloid deposition in normal aging
50/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology
Key finding: Amyloid deposition is associated with lower cognitive performance both in AD patients and in the normal elderly, but the association is modified by CR, suggesting that CR may be protective against amyloid-related cognitive impairment. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-01
Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function
40/100 ✓ Peer-reviewed Vascular contributions Neurology
Key finding: These data suggest that low-grade inflammation as assessed by high-sensitivity C-reactive protein is associated with cerebral microstructural disintegration that predominantly affects frontal pathways and corresponding executive function. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-01
Increase in hippocampal volume after electroconvulsive therapy in patients with depression: a volumetric magnetic resonance imaging study
36/100 ✓ Peer-reviewed Hippocampus size on brain scans The journal of ECT
Key finding: The hippocampal volume increases after ECT, supporting the hypothesis that hippocampus may play a central role in the treatment of depression.
Full summary, score breakdown and related studies → Original source
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2010-03-01
Decreased hippocampal volume in healthy girls at risk of depression
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Archives of general psychiatry
Key finding: Compared with individuals at low familial risk of the development of depression, high-risk individuals have reduced hippocampal volume, indicating that neuroanatomic anomalies associated with depression may precede the onset of a depressive episode and influence the development and course of this disorder. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-03-01
Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder
60/100 ✓ Peer-reviewed Hippocampus size on brain scans Archives of general psychiatry
Key finding: The findings indicate for the first time in humans that PTSD is associated with selective volume loss of the CA3/dentate gyrus subfields, consistent with animal studies, implying that chronic stress suppresses neurogenesis and dendritic branching in these structures. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-01
Rural-Urban Differences in Preventable Hospitalizations Among Community-Dwelling Veterans With Dementia
53/100 ✓ Peer-reviewed Risk factors The Journal of Rural Health
Key finding: Thirteen percent of care recipients had at least 1 ACSH. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-01
Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study
48/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica
Key finding: Though the clinical significance of these lesions remains uncertain, their distribution and prevalence correlates with cerebral amyloid angiopathy (CAA), hypertension, smoking, and cognitive deficits. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-01
Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease
44/100 ✓ Peer-reviewed Mild cognitive impairment Antioxidants & redox signaling
Key finding: Our results imply that some of the common targets of protein carbonylation correlated with AD neuropathology and suggest a possible involvement of protein modifications in the AD progression.
Full summary, score breakdown and related studies → Original source
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2010-03-01
Sleep disorders in aging and dementia
43/100 ✓ Peer-reviewed Mild cognitive impairment The journal of nutrition, health & aging
Key finding: Although around 40% of older adults complain of poor sleep, true sleep disorders are far less prevalent in healthy older adults and are frequently associated with comorbidities. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-03-01
Brain structure and obesity
51/100 ✓ Peer-reviewed Risk factors Human brain mapping
Key finding: Obesity is associated with increased risk for cardiovascular health problems including diabetes, hypertension, and stroke. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-01
2010 Alzheimer's disease facts and figures
60/100 ✓ Peer-reviewed How common it is Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Dramatic increases in the numbers of "oldest old" (aged 85 years and older) across all racial and ethnic groups will also significantly affect the numbers of people living with AD.
Full summary, score breakdown and related studies → Original source
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2010-03-01
Measuring disability across cultures--the psychometric properties of the WHODAS II in older people from seven low- and middle-income countries. The 10/66 Dementia Research Group population-based survey
46/100 ✓ Peer-reviewed Disparities International journal of methods in psychiatric research
Key finding: The Mokken results strongly support that the WHODAS II 12-item screener is a unidimensional and hierarchical scale confirming to item response theory (IRT) principles, at least at the monotone homogeneity model level. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-03-01
A systematic review and meta-analysis of ethnic differences in use of dementia treatment, care, and research
67/100 ✓ Peer-reviewed Disparities The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Compatible results were pooled in a meta-analysis.
Full summary, score breakdown and related studies → Original source
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2010-03-01
Cognitive leisure activities and their role in preventing dementia: a systematic review
56/100 ✓ Peer-reviewed Prevention and risk International journal of evidence-based healthcare
Key finding: Because of the heterogeneity of populations and interventions, meta-analyses were not possible and results are presented in narrative form. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-03-01
Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease
55/100 ✓ Peer-reviewed Genetics Annals of neurology
Key finding: Low CSF Abeta(1-42) (surrogate for Abeta amyloid load) is more closely linked to the presence of APOE epsilon4 than to clinical status. +2 more findings
Full summary, score breakdown and related studies → Original source
February 2010 2
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2010-02-28
Executive function in adolescents with Down Syndrome
41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of intellectual disability research : JIDR
Key finding: The results suggest a broad impairment in EF in adolescents with DS, and are consistent with several similar studies conducted with adults with DS. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-02-27
11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study
55/100 ✓ Peer-reviewed Treatments The Lancet Neurology
Full summary, score breakdown and related studies → Original source
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