Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 23,426–23,450 of 27,380 studies, newest first · page 938 of 1096.
November 2005 22
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2005-11-01
Reality orientation therapy combined with cholinesterase inhibitors in Alzheimer's disease: randomised controlled trial
60/100 ✓ Peer-reviewed Treatments The British journal of psychiatry : the journal of mental science
Key finding: Reality orientation therapy combined with cholinesterase inhibitors has not been evaluated in patients with Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-11-01
The Goteborg MCI study: mild cognitive impairment is a heterogeneous condition
46/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry
Key finding: Mild cognitive impairment (MCI) has been considered a transitional state between normal aging and dementia, characterised by memory impairment but normal general cognitive functioning. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-11-01
CSF amyloid beta42 and tau levels correlate with AIDS dementia complex
47/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: Because AD presence and risk are related to CSF beta-amyloid(1-42) (Abeta42), total tau (t-tau), and phosphorylated tau (p-tau), the authors examined these in ADC, AD, and controls. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-11-01
Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease
49/100 ✓ Peer-reviewed Mild cognitive impairment Archives of neurology
Key finding: These data provide evidence for clinical and functional heterogeneity among subjects with aMCI and suggest that 18FDG-PET findings combined with memory scores may be useful in predicting short-term conversion to AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-11-01
Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study
65/100 ✓ Peer-reviewed Mild cognitive impairment The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Future confirmation in a larger study is needed to fully demonstrate rosiglitazone's therapeutic potential. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-11-01
Frontotemporal dementia
48/100 ✓ Peer-reviewed Lewy body dementia The Lancet. Neurology
Key finding: Frontotemporal dementia (FTD) is a focal clinical syndrome characterised by profound changes in personality and social conduct and associated with circumscribed degeneration of the prefrontal and anterior temporal cortex.
Full summary, score breakdown and related studies → Original source
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2005-11-01
Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)
52/100 ✓ Peer-reviewed Lewy body dementia The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: The rTg(tau(P301L))4510 mouse expresses the P301L mutation in tau (4R0N) associated with frontotemporal dementia and parkinsonism linked to chromosome 17. +4 more findings
Full summary, score breakdown and related studies → Original source
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2005-11-01
Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models
44/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of disease
Key finding: However, transgenic mice over-expressing Dyrk1A do not show increased phosphorylation of tau at Thr212, thus suggesting that Dyrk1A over-expression does not trigger per se hyper-phosphorylation of tau at Thr212 in vivo. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-11-01
Validation of 2 depression screening tools in dialysis patients
49/100 ✓ Peer-reviewed Risk factors American journal of kidney diseases : the official journal of the National Kidney Foundation
Key finding: Our results validate the PHQ-9 and revalidate the BDI against a gold-standard measure for depressive disorders in the dialysis population. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-11-01
Excessive daytime sleepiness and subsequent development of Parkinson disease
53/100 ✓ Peer-reviewed Risk factors Neurology
Key finding: Excessive daytime sleepiness may be associated with an increased risk of developing Parkinson disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-11-01
Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease
77/100 ✓ Peer-reviewed How common it is The Lancet. Neurology
Key finding: Leisure-time physical activity at midlife at least twice a week was associated with a reduced risk of dementia and AD (odds ratio [OR] 0.48 [95% CI 0.25-0.91] and 0.38 [0.17-0.85], respectively), even after adjustments for age, sex, education, follow-up time, locomotor disorders, APOE genotype, vascular disorders, smoking, and alcohol drinking. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-11-01
Mild cognitive impairment and 10-year trajectories of disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly cohort
61/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: MCI was prevalent in 24.7% of participants at baseline. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-11-01
Epidemiology of and risk factors for psychosis of Alzheimer's disease: a review of 55 studies published from 1990 to 2003
65/100 ✓ Peer-reviewed Disparities The American journal of psychiatry
Key finding: Psychotic symptoms are common and persistent in patients with Alzheimer's disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2005-11-01
Systematic review of psychological approaches to the management of neuropsychiatric symptoms of dementia
65/100 ✓ Peer-reviewed Caregiving The American journal of psychiatry
Key finding: Only behavior management therapies, specific types of caregiver and residential care staff education, and possibly cognitive stimulation appear to have lasting effectiveness for the management of dementia-associated neuropsychiatric symptoms. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-11-01
Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: the LADIS study
52/100 ✓ Peer-reviewed Brain scans and imaging Journal of neurology, neurosurgery, and psychiatry
Key finding: The presence of either severe WMH or MTA was associated with a modest but non-significant increase in frequency of mild cognitive deficits (severe WMH: odds ratio (OR) = 1.9 (95% confidence interval (CI), 1.0 to 3.7); MTA present: OR = 1.5 (95% CI, 0.8 to 2.8)). +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-11-01
Association of psychiatric disorders and sleep apnea in a large cohort
46/100 ✓ Peer-reviewed Getting a diagnosis Sleep
Key finding: Study objectives We conducted the present study to determine whether psychiatric disorders are commonly associated with sleep apnea in Veterans Health Administration beneficiaries. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-11-01
Poststroke dementia
51/100 ✓ Peer-reviewed Prevention and risk The Lancet. Neurology
Key finding: Patient-related variables associated with an increased risk of PSD are increasing age, low education level, dependency before stroke, prestroke cognitive decline without dementia, diabetes mellitus, atrial fibrillation, myocardial infarction, epileptic seizures, sepsis, cardiac arrhythmias, congestive heart failure, silent cerebral infarcts, global and medial-temporal-lobe atrophy, and white-matter changes. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-11-01
What do people at risk for Alzheimer disease think about surrogate consent for research?
49/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Laypersons at heightened risk of Alzheimer disease discriminate among research scenarios of varying risks and burdens. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-11-01
Divalproex sodium in nursing home residents with possible or probable Alzheimer Disease complicated by agitation: a randomized, controlled trial
64/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: This multicenter trial showed no benefit of divalproex sodium for treatment for agitation in dementia at a mean dose of 800 mg/day over 6 weeks. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-11-01
Implementing diagnostic criteria and estimating frequency of mild cognitive impairment in an urban community
65/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: When proper normative values are used, only age and education, and not race or ethnicity, are associated with higher frequency of MCI. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-11-01
Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4
51/100 ✓ Peer-reviewed Genetics Neurology
Key finding: In the Cardiovascular Health Cognition Study, consumption of fatty fish was associated with a reduced risk of dementia and Alzheimer disease for those without the APOE epsilon4 allele. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-11-01
Metallothionein-I-II and GFAP positivity in the brains from frontotemporal dementia patients
31/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: Our findings indicate that metallothionein-I-II expression in the most affected areas is likely to be regionally distinct and layer-dependent, in that it is highest in the deep layers of the frontotemporal cortex and the allocortex (hippocampus) while insignificantly immunopositive in the occipital cortex.
Full summary, score breakdown and related studies → Original source
October 2005 3
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2005-10-31
The microglial "activation" continuum: from innate to adaptive responses
49/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation
Key finding: While classically regarded as macrophage-like cells, it is becoming increasingly clear that reactive microglia play more diverse roles in the CNS. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-10-26
Dietary intake of unsaturated fatty acids and age-related cognitive decline: a 8.5-year follow-up of the Italian Longitudinal Study on Aging
64/100 ✓ Peer-reviewed Prevention trials Neurobiology of aging
Key finding: There is evidence from a population-based study of an inverse relationship between monounsaturated fatty acids (MUFA) energy intake and age-related cognitive decline (ARCD), while high polyunsaturated fatty acids (PUFA) intake was positively associated with cognitive impairment in elderly subjects. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-10-26
Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study
48/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: The differential response to cholinergic challenge in mild cognitive impairment and Alzheimer patients may reflect a difference in the functional status of the cholinergic system between both groups, which is in line with recent results showing a differential clinical response to cholinergic treatment.
Full summary, score breakdown and related studies → Original source
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