Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,676–20,700 of 27,380 studies, newest first · page 828 of 1096.
July 2010 25
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2010-07-28
REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century
57/100 ✓ Peer-reviewed Risk factors Neurology
Key finding: These cases illustrate that the alpha-synuclein pathogenic process may start decades before the first symptoms of PD, DLB, or MSA.
Full summary, score breakdown and related studies → Original source
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2010-07-27
The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?
40/100 ✓ Peer-reviewed Risk factors Molecular psychiatry
Key finding: Major depressive disorder (MDD) has until recently been conceptualized as an episodic disorder associated with 'chemical imbalances' but no permanent brain changes. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-27
Advance directives for euthanasia in dementia: do law-based opportunities lead to more euthanasia?
36/100 ✓ Peer-reviewed End-of-life care Health policy (Amsterdam, Netherlands)
Key finding: Over the years 2005-2006, many ECPs took care of patients with dementia and an ADE, actual life termination of these patients took place very rarely and never in incompetent patients. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-27
A high-fat diet impairs neurogenesis: involvement of lipid peroxidation and brain-derived neurotrophic factor
43/100 ✓ Peer-reviewed Risk factors Neuroscience letters
Key finding: Seven weeks of HFD significantly decreased the numbers of newly generated cells in the dentate gyrus of the hippocampus without neuronal loss. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-07-26
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms Proceedings of the National Academy of Sciences of the United States of America
Key finding: Based on the results of a genome-wide screen, we show that reactive oxygen species (ROS) serve as common mediators upstream of the activation of the type III PI3 kinase, which is critical for the initiation of autophagy. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-07-26
The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis
56/100 ✓ Peer-reviewed Vascular contributions BMJ
White matter hyperintensities predict an increased risk of stroke, dementia, and death.
Full summary, score breakdown and related studies → Original source
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2010-07-23
Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression
48/100 ✓ Peer-reviewed Mild cognitive impairment Biological psychiatry
Key finding: These data support the hypothesis that neuronal endosomal dysfunction is associated with preclinical AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-19
The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 years
62/100 ✓ Peer-reviewed Mild cognitive impairment International psychogeriatrics
Key finding: Cognitive complaints are common in the elderly, and nearly one in three meet criteria for MCI.
Full summary, score breakdown and related studies → Original source
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2010-07-19
Targeting and managing behavioral symptoms in individuals with dementia: a randomized trial of a nonpharmacological intervention
65/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society
Key finding: At 16 weeks, 67.5% of intervention caregivers reported improvement in targeted problem behavior, compared with 45.8% of caregivers in a no-treatment control group (P=.002), and reduced upset with (P=.03) and enhanced confidence managing (P=.01) the behavior.
Full summary, score breakdown and related studies → Original source
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2010-07-17
AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation
36/100 ✓ Peer-reviewed Disease mechanisms Neurobiology of aging
Key finding: Hyperglycemia enhances the formation of advanced glycation end products (AGEs) that result from the auto-oxidation of glucose and fructose. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-14
In situ monitoring of health in older adults: technologies and issues
36/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society
Key finding: This article identifies and discusses the important issues regarding the use of monitoring technologies in elderly patients. +4 more findings
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2010-07-12
Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease
43/100 ✓ Peer-reviewed TREM2 and immune genetics ASN neuro
Key finding: In the present study we examined, in a transgenic model of amyloid pathology, the expression of two molecules previously implicated in decreasing the severity of autoimmune responses: TREM2 (triggering receptor expressed on myeloid cells 2) and the intracellular tolerance-associated transcript, Tmem176b (transmembrane domain protein 176b). +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-08
Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline
58/100 ✓ Peer-reviewed Disparities Neurobiology of aging
Key finding: ApoE4(+) predicted dementia significantly (hazard ratio [HR] = 2.89; 95% confidence interval [CI], 1.93-4.33), with nonsignificant sex differences. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-06
Risk for Fractures with Centrally Acting Muscle Relaxants: An Analysis of a National Medicare Advantage Claims Database
42/100 ✓ Peer-reviewed Health systems and care delivery Annals of Pharmacotherapy
Key finding: After adjusting demographic and clinical covariates, muscle relaxants, long-acting benzodiazepines, and short-acting benzodiazepines were associated with a high risk of fracture injuries, with odds ratios of 1.40 (95% CI 1.15 to 1.72; p < 0.001), 1.9 (95% CI 1.49 to 2.43; p < 0.001), and 1.33 (95% CI 1.15 to 1.55; p < 0.001), respectively. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-06
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
53/100 ✓ Peer-reviewed Lewy body dementia The EMBO journal
Key finding: The majority of fALS-associated mutations occur within the NLS and impair nuclear import to a degree that correlates with the age of disease onset. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-06
Assessment of dementia in ethnic minority patients in Europe: a European Alzheimer's Disease Consortium survey
41/100 ✓ Peer-reviewed Disparities International psychogeriatrics
Key finding: Ethnic minority patients are seen on a regular basis in European dementia clinics. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-07 month only
Bapineuzumab
38/100 ✓ Peer-reviewed Clinical trials Expert opinion on biological therapy
Key finding: OF THE FIELD: Alzheimer's disease is the leading cause of dementia in the elderly, and there is no disease-modifying therapy yet available.
Full summary, score breakdown and related studies → Original source
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2010-07-01
CSF-tau and CSF-Abeta(1-42) in posterior cortical atrophy
45/100 ✓ Peer-reviewed Tau biomarkers Dementia and geriatric cognitive disorders
Key finding: The Abeta(1-42), T-tau and P-tau(181) levels in PCA patients differed significantly (p < 0.02) from those in healthy controls but were indistinguishable from subjects with a clinical diagnosis of AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
An examination of Alzheimer's disease case definitions using Medicare claims and survey data
55/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Different information sources yield widely varied prevalence and expenditure estimates.
Full summary, score breakdown and related studies → Original source
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2010-07-01
Survival and comfort after treatment of pneumonia in advanced dementia
40/100 ✓ Peer-reviewed End-of-life care Archives of internal medicine
Key finding: Antimicrobial treatment of suspected pneumonia episodes is associated with prolonged survival but not with improved comfort in nursing home residents with advanced dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
Rapid appraisal of barriers to the diagnosis and management of patients with dementia in primary care: a systematic review
60/100 ✓ Peer-reviewed Caregiving BMC family practice
Key finding: Much can still be done in the way of service development and provision, GP training and education, and the eradication of stigma attached to dementia, to improve the early detection and management of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-07-01
Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
40/100 ✓ Peer-reviewed Disease mechanisms Nature neuroscience
Key finding: Diverse lines of evidence suggest that amyloid-beta (Abeta) peptides have a causal role in its pathogenesis, but the underlying mechanisms remain uncertain.
Full summary, score breakdown and related studies → Original source
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2010-07-01
Does corticobasal degeneration exist? A clinicopathological re-evaluation
43/100 ✓ Peer-reviewed Risk factors Brain : a journal of neurology
Key finding: The pathological findings of corticobasal degeneration are associated with several distinct clinical syndromes, and the corticobasal syndrome has been linked with a number of diverse pathologies. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-07-01
Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons
36/100 ✓ Peer-reviewed Treatments The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Live imaging of fluorescent protein-tagged organelles revealed a marked decrease in axonal trafficking of dense-core vesicles and mitochondria in the presence of 0.5 microm AbetaOs. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE
36/100 ✓ Peer-reviewed Genetics Neurobiology of aging
Key finding: The genetic component of this late onset form of AD has been the target of a large number of studies, because only one genetic risk factor (APOE4) has been consistently associated with the disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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