Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,826–20,850 of 27,380 studies, newest first · page 834 of 1096.
May 2010 20
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2010-05-01
Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia
57/100 ✓ Peer-reviewed Hippocampus size on brain scans JAMA
Key finding: Compared with healthy controls, adults with SCA had poorer cognitive performance, which was associated with anemia and age. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-01
Interventions to reduce cognitive decline in aging
36/100 ✓ Peer-reviewed Prevention trials Journal of psychosocial nursing and mental health services
Key finding: Overall research findings support positive effects of cognitive and physical activity, social engagement, and therapeutic nutrition in optimizing cognitive aging.
Full summary, score breakdown and related studies → Original source
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2010-05-01
ADF/Cofilin-actin rods in neurodegenerative diseases
36/100 ✓ Peer-reviewed Disease mechanisms Current Alzheimer research
Key finding: Rods can occlude neurites and block vesicle transport. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-01
Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment
41/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Our previous studies using a gene-based approach in mouse model to block the conversion of testosterone into estrogen (aromatase gene knock-out, ArKO), found a depletion of estrogen and increase in testosterone endogenously in males. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-01
Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects
52/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Initial CSF studies by the ADNI Biomarker Core revealed a pathological CSF biomarker signature of AD defined by the combination of Abeta1-42 and total tau (T-tau) that effectively delineates mild AD in the large multisite prospective clinical investigation conducted in ADNI. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-05-01
The Alzheimer's disease neuroimaging initiative: progress report and future plans
54/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: FDG PET, C-11 Pittsburgh compound B PET, and CSF measurements of Abeta and tau were significant predictors of cognitive decline and brain atrophy. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-05-01
Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline
53/100 ✓ Peer-reviewed Lewy body dementia The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Importantly, the presence of Lewy body pathology in AD is associated with a more aggressive disease course and accelerated cognitive dysfunction. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-01
User evaluation of the DEMentia-specific Digital Interactive Social Chart (DEM-DISC). A pilot study among informal carers on its impact, user friendliness and, usefulness
43/100 ✓ Peer-reviewed Digital health tools Aging & mental health
Key finding: The positive effects might be caused by the systematic and tailored individual way of information provisioning by DEM-DISC.
Full summary, score breakdown and related studies → Original source
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2010-05-01
Fluorodeoxyglucose F18 positron emission tomography in progressive apraxia of speech and primary progressive aphasia variants
46/100 ✓ Peer-reviewed Digital health tools Archives of neurology
Key finding: Twenty-one patients showed FDG hypometabolism; the remaining 3 did not.
Full summary, score breakdown and related studies → Original source
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2010-05-01
The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core
69/100 ✓ Peer-reviewed How common it is Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: ADNI has demonstrated the feasibility and utility of multicenter PET studies and is helping to clarify the role of biomarkers in the study of aging and dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-01
The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease
55/100 ✓ Peer-reviewed Disparities International journal of geriatric psychiatry
Key finding: The results suggest that APOE epsilon4 and heavy drinking and heavy smoking lower the age of onset for AD in an additive fashion. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-05-01
Greater risk of dementia when spouse has dementia? The Cache County study
51/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: Additional (not mutually exclusive) explanations for findings are discussed.
Full summary, score breakdown and related studies → Original source
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2010-05-01
Profile of cognitive impairment in Parkinson's disease
41/100 ✓ Peer-reviewed Caregiving Brain pathology (Zurich, Switzerland)
Key finding: Cognitive impairment (CI) is a common nonmotor complication of Parkinson's disease (PD), and is associated with significant disability for patients and burden for caregivers.
Full summary, score breakdown and related studies → Original source
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2010-05-01
Short-form Zarit Caregiver Burden Interviews were valid in advanced conditions
64/100 ✓ Peer-reviewed Caregiving Journal of clinical epidemiology
Key finding: All six short-form ZBI have very good validity, internal consistency, and discriminative ability. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-05-01
Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management
40/100 ✓ Peer-reviewed Getting a diagnosis CNS drugs
Key finding: Frontotemporal lobar degeneration (FTLD) is a clinically and pathologically heterogeneous syndrome, characterized by progressive decline in behaviour or language associated with degeneration of the frontal and anterior temporal lobes. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-01
Is physical activity a potential preventive factor for vascular dementia? A systematic review
69/100 ✓ Peer-reviewed Prevention and risk Aging & mental health
Key finding: We conclude that there is evidence supporting the hypothesis that physical activity is likely to prevent the development of VaD, and should be highlighted as part of secondary prevention programmes in people at risk for cerebrovascular disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-01
An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease
43/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: These new data explain the mean age at disease onset for patients with the APOE4/4 genotype and differentiate 2 forms of TOMM40 poly-T polymorphisms linked to APOE, with each form associated with a different age at disease onset distribution. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-01
CSF biomarkers predict a more malignant outcome in Alzheimer disease
55/100 ✓ Peer-reviewed Genetics Neurology
Key finding: A subgroup of patients with Alzheimer disease with extreme levels of CSF biomarkers exhibits worse clinical outcomes over time, including faster progression of cognitive deficits, no response to ChEI treatment, and a higher mortality.
Full summary, score breakdown and related studies → Original source
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2010-05-01
Occupational exposure to pesticides increases the risk of incident AD: the Cache County study
54/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Commonly used organophosphate and organochlorine pesticides inhibit acetylcholinesterase at synapses in the somatic, autonomic, and central nervous systems and may therefore have lasting effects on the nervous system. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-05-01
Genome-wide analysis of genetic loci associated with Alzheimer disease
78/100 ✓ Peer-reviewed Genetics JAMA
Key finding: Two loci were identified to have genome-wide significance for the first time: rs744373 near BIN1 (odds ratio [OR],1.13; 95% confidence interval [CI],1.06-1.21 per copy of the minor allele; P = 1.59x10(-11)) and rs597668 near EXOC3L2/BLOC1S3/MARK4 (OR, 1.18; 95% CI, 1.07-1.29; P = 6.45x10(-9)). +2 more findings
Full summary, score breakdown and related studies → Original source
April 2010 5
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2010-04-22
Molecular mechanisms of neurodegeneration in Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms Human molecular genetics
Key finding: In addition, recent evidence suggests that alterations in adult neurogenesis in the hippocampus might play a role. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-04-21
Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice
48/100 ✓ Peer-reviewed Inflammation and the immune system Molecular brain
Key finding: Parkinson's disease (PD) is the most common movement disorder. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-21
Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease
64/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology
Key finding: Recently, we showed that behavioural variant frontotemporal dementia and Alzheimer's disease cause atrophy within two major networks, an anterior 'Salience Network' (atrophied in behavioural variant frontotemporal dementia) and a posterior 'Default Mode Network' (atrophied in Alzheimer's disease). +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-19
The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia
57/100 ✓ Peer-reviewed Caregiving Brain : a journal of neurology
Key finding: The quantity of amyloid beta-protein containing plaques does not correlate well with clinical status, suggesting that if amyloid beta-protein is pathogenic it involves soluble non-plaque material. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-16
Role of carnitine in disease
40/100 ✓ Peer-reviewed Brain scans and imaging Nutrition & metabolism
Key finding: Carnitine deficiency occurs in aberrations of carnitine regulation in disorders such as diabetes, sepsis, cardiomyopathy, malnutrition, cirrhosis, endocrine disorders and with aging. +4 more findings
Full summary, score breakdown and related studies → Original source
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