Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,326–18,350 of 27,380 studies, newest first · page 734 of 1096.
October 2013 25
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2013-10-23
Impact of harmonization of collection tubes on Alzheimer's disease diagnosis
47/100 ✓ Peer-reviewed Biomarkers Alzheimer s & Dementia
Key finding: The predictive value of Aβ42 was highly affected by the type of collection tube used. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-23
Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease
36/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: In conclusion, the various GFAP isoforms show differential transcript levels and are upregulated in a concerted manner in AD.
Full summary, score breakdown and related studies → Original source
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2013-10-23
Higher glucose levels associated with lower memory and reduced hippocampal microstructure
59/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology
Key finding: Our results indicate that even in the absence of manifest type 2 diabetes mellitus or impaired glucose tolerance, chronically higher blood glucose levels exert a negative influence on cognition, possibly mediated by structural changes in learning-relevant brain areas. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-23
Impaired glycemia increases disease progression in mild cognitive impairment
57/100 ✓ Peer-reviewed Mild cognitive impairment Neurobiology of aging
Key finding: Insulin resistance and type 2 diabetes are associated with cognitive decline and increased risk for Alzheimer's disease (AD). +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-19
Classification and pathology of primary progressive aphasia
50/100 ✓ Peer-reviewed Digital health tools Neurology
Key finding: The final cohort comprised 52 patients, 30 of whom met basic PPA criteria. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-19
Neuroinflammation: the role and consequences
50/100 ✓ Peer-reviewed Inflammation and the immune system Neuroscience research
Key finding: This review examines the consequences of excessive and prolonged neuroinflammation, particularly its damaging effects on cellular and/or brain function, as well as its relevance to disease progression and possible interventions. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-19
Why Alzheimer trials fail: removing soluble oligomeric beta amyloid is essential, inconsistent, and difficult
43/100 ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of aging
Key finding: Their concentration is strongly correlated with synaptic impairment in animals and parallel cognitive decline in animals and humans. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-18
Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions
50/100 ✓ Peer-reviewed Risk factors The lancet. Diabetes & endocrinology
Key finding: Type 2 diabetes is associated with dementia, and also with more slight cognitive decrements.
Full summary, score breakdown and related studies → Original source
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2013-10-18
Connected speech as a marker of disease progression in autopsy-proven Alzheimer's disease
63/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology
Key finding: Previous studies from our group have shown that language changes may be reflected in connected speech production in the earliest stages of typical Alzheimer's disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-17
Dominantly Inherited Alzheimer Network: facilitating research and clinical trials
55/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy
Key finding: The Dominantly Inherited Alzheimer Network (DIAN) is an international registry of individuals at risk for developing autosomal dominant Alzheimer's disease (AD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-17
Quality palliative care for cancer and dementia in five European countries: some common challenges
40/100 ✓ Peer-reviewed End-of-life care Aging & mental health
Key finding: These are not problems distinct to palliative care, but they may have different origins and explanations compared to other areas of health care. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-10-17
Non-pharmacological interventions and neuroplasticity in early stage Alzheimer's disease
36/100 ✓ Peer-reviewed Prevention trials Expert review of neurotherapeutics
Key finding: Non-pharmacological interventions have the potential to reduce cognitive decline and to improve psychosocial aspects in mild cognitive impairment and Alzheimer's dementia, and the absence of side effects makes them a favorable option also for preventive strategies. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-17
Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles
40/100 ✓ Peer-reviewed Disease mechanisms Brain : a journal of neurology
Key finding: To investigate whether Alzheimer's disease is associated with changes in the absolute cell numbers of ageing brains, we used the isotropic fractionator, a novel technique designed to determine the absolute cellular composition of brain regions. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-17
Sleep Drives Metabolite Clearance from the Adult Brain
61/100 ✓ Peer-reviewed Disease mechanisms Science
The conservation of sleep across all animal species suggests that sleep serves a vital function.
Full summary, score breakdown and related studies → Original source
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2013-10-17
Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins
54/100 ✓ Peer-reviewed Lewy body dementia Acta neuropathologica
Key finding: Moreover, an antibody targeting the putative carboxyl terminus of DPR proteins can detect inclusion pathology in C9orf72 repeat expansion carriers suggesting that the non-ATG translation continues through the entire repeat and beyond.
Full summary, score breakdown and related studies → Original source
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2013-10-16
Dementia in relation to family caregiver involvement and burden in long-term care
38/100 ✓ Peer-reviewed Health systems and care delivery Journal of applied gerontology : the official journal of the Southern Gerontological Society
Key finding: Adjusted analyses found that although the amount of family visitation did not significantly vary by resident cognitive status (15 versus 20 visits/month to persons with and without dementia, respectively), the nature of the visit did. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-10-16
TREM2 and Neurodegenerative Disease
51/100 ✓ Peer-reviewed TREM2 and immune genetics New England Journal of Medicine
We and other members of the Alzheimer’s Disease Genetics Consortium assembled multiple data sets from a total of 5896 black patients (1968 cases and 3928 controls).
Full summary, score breakdown and related studies → Original source
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2013-10-16
CSF biomarker changes precede symptom onset of mild cognitive impairment
61/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: This study evaluated longitudinal CSF biomarker measures collected when participants were cognitively normal to determine the magnitude and time course of biomarker changes before the onset of clinical symptoms in subjects with mild cognitive impairment (MCI). +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-16
Heterozygous TREM2 mutations in frontotemporal dementia
57/100 ✓ Peer-reviewed TREM2 and immune genetics Neurobiology of aging
Key finding: The objective of this study was to evaluate whether heterozygous TREM2 genetic variations might be associated to the risk of FTD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-16
Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS
56/100 ✓ Peer-reviewed Lewy body dementia Acta neuropathologica
Key finding: We show that ectopic expression of (CCCCGG)66 in cultured cells results in foci formation. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-10-16
Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults
68/100 ✓ Peer-reviewed Caregiving Neurology
Key finding: Arterial stiffness was associated with Aβ plaque deposition in the brain, independent of BP and APOE ε4 allele. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-16
Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity
57/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: The incidence of amyloid PET positivity is approximately 13% per year among CN participants over age 70 sampled from a population-based cohort. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-15
Improved memory function two years after bariatric surgery
41/100 ✓ Peer-reviewed Cognitive tests and assessment Obesity (Silver Spring, Md.)
Key finding: These findings suggest that cognitive benefits of bariatric surgery may extend to 24-months postoperatively. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-14
Do people with dementia die at their preferred location of death? A systematic literature review and narrative synthesis
64/100 ✓ Peer-reviewed End-of-life care Age and ageing
Key finding: The aim of this study was to undertake a systematic review and narrative synthesis of the literature concerning place of death of people with dementia and the preferences for location of death of people with dementia as well as family carers and healthcare providers preferred location of death for patients with dementia.
Full summary, score breakdown and related studies → Original source
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2013-10-14
Cerebrospinal fluid biomarkers for Alzheimer disease and subcortical axonal damage in 5,542 clinical samples
43/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy
Key finding: The association between an AD-like signature using the established biomarkers Aβ42, T-tau, and P-tau with increased levels of NFL provides in vivo evidence of an association between AD and subcortical axonal degeneration in this uniquely large dataset of CSF samples tested for dementia biomarkers. +1 more finding
Full summary, score breakdown and related studies → Original source
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