Newest studies

Prevalence of Alzheimer's Disease in a Community Population of Older Persons

53/100 ✓ Peer-reviewed How common it is JAMA

Key finding: This prevalence rate was strongly associated with age. +2 more findings

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Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported

51/100 ✓ Peer-reviewed How common it is JAMA

Clinically diagnosed Alzheimer's disease and other dementing illnesses were assessed in a geographically defined US community.

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Retinal ganglion cell degeneration in Alzheimer's disease

36/100 ✓ Peer-reviewed Brain scans and imaging Brain research

Key finding: The results show degeneration in the retinal ganglion cells (RGCs) characterized by a vacuolated, 'frothy' appearance of the cytoplasm. +1 more finding

• Brain Biology

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A4 protein in Alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition

36/100 ✓ Peer-reviewed Biomarkers Journal of neuropathology and experimental neurology

Key finding: Using A4 protein antisera, we found an amorphous non-congophilic, form of plaque, which was not seen in Bielschowsky silver staining or Bodian impregnations. +1 more finding

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The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): socio-demographic correlates, reliability, validity and some norms

44/100 ✓ Peer-reviewed Cognitive tests and assessment Psychological Medicine

The IQCODE is a questionnaire which asks an informant about changes in an elderly person's everyday cognitive function.

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Qualitative and quantitative comparison of brain proteins in Alzheimer's disease

28/100 ✓ Peer-reviewed Biomarkers Biological chemistry Hoppe-Seyler

Key finding: Because we needed to accurately compare the concentration of several proteins in brain extracts to investigate the etiology of the disease, the quantitative aspect of immunoblotting was assessed and the results compared for a soluble component with those obtained by electroimmunoassay. +2 more findings

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Immune system response in Alzheimer's disease

45/100 ✓ Peer-reviewed Biomarkers The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Key finding: Involvement of the immune system in the pathogenesis of Alzheimer's disease was demonstrated in two ways: by the attachment of complement proteins to diseased tissue, and by the activation of cells associated with the immune system.

• Brain Biology

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Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

52/100 ✓ Peer-reviewed Disease mechanisms Neuron

Key finding: Transcripts encoding isoforms with the insertions are expressed in an adult-specific manner. +2 more findings

• Brain Biology

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Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease

52/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroimmunology

Key finding: BAP was detected in forms varying from diffuse amorphous deposits to compact spherical masses. +3 more findings

• Brain Biology

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[The significance of measurement of contents of serum serine protease inhibitors in senile dementia of the Alzheimer type]

31/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Rinsho shinkeigaku = Clinical neurology

Key finding: DAT group showed statistically significant increase of serum alpha 1-antichymotrypsin content, as compared with normal control group (p less than 0.001), mixed type dementia group (p less than 0.05) and other 6 groups (p less than 0.001). +2 more findings

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Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

48/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America

Key finding: Interleukin 1, an immune response-generated cytokine that stimulates astrocyte proliferation and reactivity (astrogliosis), was present in up to 30 times as many glial cells in tissue sections of brain from patients with Down syndrome and Alzheimer disease compared with age-matched control subjects. +2 more findings

• Down Syndrome
• Brain Biology

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Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease

41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Nature

Key finding: Until now, the pathological lesions of the disease have been found only in the brain, although reports of phenotypic abnormalities in non-neural tissues have suggested that Alzheimer's disease may be a widespread, systemic disorder. +2 more findings

• Brain Biology
• Down Syndrome
• Genetics

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Genetic studies support a neuronal origin for the beta amyloid polypeptide

32/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of aging

Key finding: Significant alterations in levels of amyloid precursor mRNAs are observed specifically in neurons known to be risk in Alzheimer's disease and Down syndrome.

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The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease

68/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: The tests selected for this study measured the primary cognitive manifestations of AD across a range of severity of the disorder, and discriminated between normal subjects and those with mild and moderate dementia. +4 more findings

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Tumor necrosis factor identified in multiple sclerosis brain

40/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of Experimental Medicine

Key finding: In brain lesions in MS, and subacute sclerosing panencephalitis, TNF+ cells were demonstrated. +2 more findings

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Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease

36/100 ✓ Peer-reviewed Disease mechanisms Neuroscience letters

Key finding: We found in the AD cases an average 50% decrease in the density of the granular neuropil immunoreaction in parietal, temporal and midfrontal cortex.

• Brain Biology

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The influence of education, social class and sex on Mini-Mental State scores

42/100 ✓ Peer-reviewed Cognitive tests and assessment Psychological medicine

Key finding: Even when demented cases were removed from analysis, respondents with relatively little education, together with those in social classes III-manual and below, were significantly more likely to score below the cut-off point used in North American community surveys to denote 'cognitive impairment'. +3 more findings

• Diagnosis

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Absence of familial association between dementia of Alzheimer type and Down syndrome

41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of medical genetics

Key finding: Our results argue against an excess of dementia cases with insidious onset suggestive of DAT in families of children with classical trisomy 21.

• Down Syndrome

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A prospective study of Alzheimer disease in Down syndrome

49/100 ✓ Peer-reviewed How common it is Archives of neurology

Key finding: Of note, 41 (84%) demented individuals with Down syndrome developed seizures. +4 more findings

• Down Syndrome
• Brain Biology

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An epidemiological study of dementia in a rural population of elderly women

38/100 ✓ Peer-reviewed Disparities The British journal of psychiatry : the journal of mental science

Key finding: The prevalence rates overall did not differ from those reported in other recent studies, but the rates for levels greater than mild/moderate were lower, despite the inclusion of subjects in institutions.

• Health Equity

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Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

41/100 ✓ Peer-reviewed Risk genes beyond APOE Science (New York, N.Y.)

Key finding: Whether amyloid itself contributes to the neurodegenerative process or is simply a by-product of that process is unknown. +4 more findings

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The Alzheimer amyloid precursor protein maps to human chromosome 21 bands q21.105-q21.05

39/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Genomics

Key finding: Our findings exclude the APP gene from the minimal region producing the classical phenotypic features of Down syndrome.

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Hypothesis: Alzheimer's disease is a phylogenetic disease

37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Medical hypotheses

Key finding: Increments in G(x) accompanied the increased gene expression that sustained brain growth and differentiation during hominid evolution, particularly of the regions liable to Alzheimer pathology, and further occur in Down syndrome [suggesting that genes on chromosome 21 are included in G(x)].

• Genetics

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Radiation-induced dementia in patients cured of brain metastases

53/100 ✓ Peer-reviewed How common it is Neurology

Key finding: Autopsies on 2 patients revealed diffuse chronic edema of the hemispheric white matter in the absence of tumor recurrence. +1 more finding

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Radioresistant DNA synthesis and human genetic diseases

35/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Human genetics

Key finding: Four strains demonstrated RDS that was less pronounced than in most AT cells: one was from a patient with Nijmegen breakage syndrome, one was from a patient without ataxia but with choreiform movement disorder, telangiectasia, and elevated concentrations of alpha-fetoprotein in the blood, and two were from AT patients. +1 more finding

• Genetics

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