Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 23,326–23,350 of 27,380 studies, newest first · page 934 of 1096.

January 2006 25

  1. 2006-01-01

    Biological markers of age-related memory deficits: treatment of senescent physiology

    ✓ Peer-reviewed Clinical safety CNS drugs

    Key finding: An important aspect of defining memory decline is the distinction between dementia as a result of neurological diseases, such as Alzheimer's disease, and memory loss not specifically associated with disease. +3 more findings

  2. 2006-01-01

    Impaired glutamate transport in a mouse model of tau pathology in astrocytes

    ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Reduced GLT-1 expression was associated with a progressive decrease in sodium-dependent glutamate transport capacity.

  3. 2006-01-01

    Current pharmacotherapy for Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Annual review of medicine

    Key finding: Dementia in AD results from progressive synaptic loss and neuronal death.

  4. 2006-01-01

    Clinical and pathological characterization of progressive aphasia

    ✓ Peer-reviewed Disease mechanisms Annals of neurology

    Key finding: Progressive aphasia is best seen as a composite of two conditions, on both clinical and pathological levels: progressive nonfluent aphasia and semantic dementia. +1 more finding

  5. 2006 no date recorded — placed by publication year

    Using thematic analysis in psychology

    ✓ Peer-reviewed Cognitive tests and assessment Qualitative Research in Psychology

    Thematic analysis is a poorly demarcated, rarely acknowledged, yet widely used qualitative analytic method within psychology.

  6. 2006-01-01

    Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years

    ✓ Peer-reviewed Inflammation and the immune system Journal of Alzheimer's disease : JAD

    Key finding: The first was the identification of activated microglia in association with the lesions. +3 more findings

  7. 2006-01-01

    CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS

    ✓ Peer-reviewed Inflammation and the immune system The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Little is known about whether human immunodeficiency virus 1 (HIV-1) infection of leukocytes affects their ability to transmigrate in response to chemokines and to alter BBB integrity. +3 more findings

  8. 2006-01-01

    Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications

    ✓ Peer-reviewed Brain tissue and pathology Current topics in developmental biology

    Key finding: These include Alzheimer's disease, Parkinson's disease, tauopathies, and polyglutamine expansion diseases [e.g., Huntington's disease; and various spinocerebellar ataxias (SCAs), like SCA3]. +3 more findings

  9. 2006-01-01

    The Geriatric Depression Scale and the Cornell Scale for Depression in Dementia. A validity study

    ✓ Peer-reviewed Cognitive tests and assessment Nordic journal of psychiatry

    Key finding: The sensitivity and specificity, and the convergent and criterion validity of the two scales as well as the inter-rater reliability of the CSDD are reported. +3 more findings

  10. 2006-01-01

    Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments

    ✓ Peer-reviewed Risk genes beyond APOE Neurology

    Key finding: Tremendous progress has been made in the recent past toward the characterization of beta- and gamma-secretases. +1 more finding

  11. 2006-01-01

    The cerebral beta-amyloid angiopathies: hereditary and sporadic

    ✓ Peer-reviewed Risk genes beyond APOE Brain pathology (Zurich, Switzerland)

    Key finding: Amino acid substitutions at 4 sites in the beta-amyloid precursor protein, all situated within the beta-amyloid peptide sequence itself, have been shown to cause heritable forms of CAA. +3 more findings

  12. 2006-01-01

    Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine

    ✓ Peer-reviewed Risk genes beyond APOE Acta pharmacologica Sinica

    Key finding: Compared with tacrine, donepezil, and rivastigmine, HupA has better penetration through the blood-brain barrier, higher oral bioavailability, and longer duration of AChE inhibitory action. +3 more findings

  13. 2006-01-01

    Neuropathologic substrate of mild cognitive impairment

    ✓ Peer-reviewed Mild cognitive impairment Archives of neurology

    Key finding: Patients with MCI showed no significant difference (P>.05) in the number of diffuse plaques from that in normal controls or patients with EAD. +2 more findings

  14. 2006-01-01

    Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death

    ✓ Peer-reviewed Lewy body dementia The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Electron microscopy confirmed the cell and axonal degeneration and revealed cytoplasmic inclusions in dendrites and axons. +1 more finding

  15. 2006-01-01

    Soluble amyloid-beta in the brain: the scarlet pimpernel

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of Alzheimer's disease : JAD

    Key finding: First, we observed that N-terminal truncated peptides are the major components of soluble and insoluble Abeta in AD; secondly, that all sAbeta species belong to the 42 form and the sAbeta x-40 species is virtually absent in AD parenchyma; thirdly, that Abeta42 in the soluble form is non-detectable by immunoblots in plaque-free, normal brains. +1 more finding

  16. 2006-01-01

    Brain and brawn: parallels in oxidative strength

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neurology

    Key finding: Neuronal oxidative stress occurs early in the progression of Alzheimer disease (AD), significantly before the development of the pathologic hallmarks, neurofibrillary tangles, and senile plaques.

  17. 2006-01-01

    Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neurology

    Key finding: APP(+1) is present in many neurons and beaded neurites in very young cases of DS, which suggests that it is axonally transported. +2 more findings

  18. 2006-01-01

    An overview on Primary Progressive Aphasia and its variants

    ✓ Peer-reviewed Digital health tools Behavioural neurology

    Key finding: The neuropsychological data demonstrated that SD patients show the most characteristic pattern of impairment, while PNFA and LPA overlap within many cognitive domains.

  19. 2006-01-01

    Efficacy of language assessment in Alzheimer's disease: comparing in-person examination and telemedicine

    ✓ Peer-reviewed Digital health tools Clinical interventions in aging

    Key finding: Telemedicine can improve access to speech and language evaluation services which is relevant to both dementia and other neurological diseases of the elderly. +3 more findings

  20. 2006-01-01

    Risk of dementia in diabetes mellitus: a systematic review

    ✓ Peer-reviewed How common it is The Lancet. Neurology

    Key finding: The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology, but which of these mechanisms are clinically relevant is unclear.

  21. 2006-01-01

    Cross-cultural study comparing the association of familism with burden and depressive symptoms in two samples of Hispanic dementia caregivers

    ✓ Peer-reviewed Disparities Aging & mental health

    Key finding: Familism has been pointed out as a key value in Hispanic culture that may or may not be associated with caregiver distress. +3 more findings

  22. 2006-01-01

    Interleukin-6 is associated with cognitive function: the Northern Manhattan Study

    ✓ Peer-reviewed Disparities Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    Key finding: IL-6 levels were negatively associated with performance on the MMSE in this multiethnic cohort. +4 more findings

  23. 2006-01-01

    Hippocampal atrophy in Alzheimer disease: age matters

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: Aging and AD were independently associated with smaller hippocampal volume.

  24. 2006-01-01

    Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people

    ✓ Peer-reviewed Brain scans and imaging Archives of general psychiatry

    Key finding: Atrophy of the hippocampus and amygdala on MRI in cognitively intact elderly people predicts dementia during a 6-year follow-up. +4 more findings

  25. 2006-01-01

    Cerebral microbleeds on MRI: prevalence, associations, and potential clinical implications

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: Cerebral microbleeds might indicate a higher risk of future intracerebral hemorrhage and may be a marker of cerebral small-vessel disease and cerebral amyloid angiopathy. +3 more findings

Browse the library by subject, with the full score breakdown →