Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 23,326–23,350 of 27,380 studies, newest first · page 934 of 1096.
January 2006 25
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2006-01-01
Biological markers of age-related memory deficits: treatment of senescent physiology
36/100 ✓ Peer-reviewed Clinical safety CNS drugs
Key finding: An important aspect of defining memory decline is the distinction between dementia as a result of neurological diseases, such as Alzheimer's disease, and memory loss not specifically associated with disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
Impaired glutamate transport in a mouse model of tau pathology in astrocytes
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Reduced GLT-1 expression was associated with a progressive decrease in sodium-dependent glutamate transport capacity.
Full summary, score breakdown and related studies → Original source
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2006-01-01
Current pharmacotherapy for Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms Annual review of medicine
Key finding: Dementia in AD results from progressive synaptic loss and neuronal death.
Full summary, score breakdown and related studies → Original source
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2006-01-01
Clinical and pathological characterization of progressive aphasia
47/100 ✓ Peer-reviewed Disease mechanisms Annals of neurology
Key finding: Progressive aphasia is best seen as a composite of two conditions, on both clinical and pathological levels: progressive nonfluent aphasia and semantic dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006 no date recorded — placed by publication year
Using thematic analysis in psychology
51/100 ✓ Peer-reviewed Cognitive tests and assessment Qualitative Research in Psychology
Thematic analysis is a poorly demarcated, rarely acknowledged, yet widely used qualitative analytic method within psychology.
Full summary, score breakdown and related studies → Original source
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2006-01-01
Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years
44/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Alzheimer's disease : JAD
Key finding: The first was the identification of activated microglia in association with the lesions. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS
47/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Little is known about whether human immunodeficiency virus 1 (HIV-1) infection of leukocytes affects their ability to transmigrate in response to chemokines and to alter BBB integrity. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications
44/100 ✓ Peer-reviewed Brain tissue and pathology Current topics in developmental biology
Key finding: These include Alzheimer's disease, Parkinson's disease, tauopathies, and polyglutamine expansion diseases [e.g., Huntington's disease; and various spinocerebellar ataxias (SCAs), like SCA3]. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
The Geriatric Depression Scale and the Cornell Scale for Depression in Dementia. A validity study
47/100 ✓ Peer-reviewed Cognitive tests and assessment Nordic journal of psychiatry
Key finding: The sensitivity and specificity, and the convergent and criterion validity of the two scales as well as the inter-rater reliability of the CSDD are reported. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments
47/100 ✓ Peer-reviewed Risk genes beyond APOE Neurology
Key finding: Tremendous progress has been made in the recent past toward the characterization of beta- and gamma-secretases. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-01-01
The cerebral beta-amyloid angiopathies: hereditary and sporadic
47/100 ✓ Peer-reviewed Risk genes beyond APOE Brain pathology (Zurich, Switzerland)
Key finding: Amino acid substitutions at 4 sites in the beta-amyloid precursor protein, all situated within the beta-amyloid peptide sequence itself, have been shown to cause heritable forms of CAA. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine
45/100 ✓ Peer-reviewed Risk genes beyond APOE Acta pharmacologica Sinica
Key finding: Compared with tacrine, donepezil, and rivastigmine, HupA has better penetration through the blood-brain barrier, higher oral bioavailability, and longer duration of AChE inhibitory action. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
Neuropathologic substrate of mild cognitive impairment
47/100 ✓ Peer-reviewed Mild cognitive impairment Archives of neurology
Key finding: Patients with MCI showed no significant difference (P>.05) in the number of diffuse plaques from that in normal controls or patients with EAD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
53/100 ✓ Peer-reviewed Lewy body dementia The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Electron microscopy confirmed the cell and axonal degeneration and revealed cytoplasmic inclusions in dendrites and axons. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-01-01
Soluble amyloid-beta in the brain: the scarlet pimpernel
31/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of Alzheimer's disease : JAD
Key finding: First, we observed that N-terminal truncated peptides are the major components of soluble and insoluble Abeta in AD; secondly, that all sAbeta species belong to the 42 form and the sAbeta x-40 species is virtually absent in AD parenchyma; thirdly, that Abeta42 in the soluble form is non-detectable by immunoblots in plaque-free, normal brains. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-01-01
Brain and brawn: parallels in oxidative strength
42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurology
Key finding: Neuronal oxidative stress occurs early in the progression of Alzheimer disease (AD), significantly before the development of the pathologic hallmarks, neurofibrillary tangles, and senile plaques.
Full summary, score breakdown and related studies → Original source
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2006-01-01
Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies
39/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurology
Key finding: APP(+1) is present in many neurons and beaded neurites in very young cases of DS, which suggests that it is axonally transported. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
An overview on Primary Progressive Aphasia and its variants
44/100 ✓ Peer-reviewed Digital health tools Behavioural neurology
Key finding: The neuropsychological data demonstrated that SD patients show the most characteristic pattern of impairment, while PNFA and LPA overlap within many cognitive domains.
Full summary, score breakdown and related studies → Original source
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2006-01-01
Efficacy of language assessment in Alzheimer's disease: comparing in-person examination and telemedicine
36/100 ✓ Peer-reviewed Digital health tools Clinical interventions in aging
Key finding: Telemedicine can improve access to speech and language evaluation services which is relevant to both dementia and other neurological diseases of the elderly. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
Risk of dementia in diabetes mellitus: a systematic review
73/100 ✓ Peer-reviewed How common it is The Lancet. Neurology
Key finding: The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology, but which of these mechanisms are clinically relevant is unclear.
Full summary, score breakdown and related studies → Original source
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2006-01-01
Cross-cultural study comparing the association of familism with burden and depressive symptoms in two samples of Hispanic dementia caregivers
42/100 ✓ Peer-reviewed Disparities Aging & mental health
Key finding: Familism has been pointed out as a key value in Hispanic culture that may or may not be associated with caregiver distress. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
Interleukin-6 is associated with cognitive function: the Northern Manhattan Study
47/100 ✓ Peer-reviewed Disparities Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Key finding: IL-6 levels were negatively associated with performance on the MMSE in this multiethnic cohort. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
Hippocampal atrophy in Alzheimer disease: age matters
47/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Aging and AD were independently associated with smaller hippocampal volume.
Full summary, score breakdown and related studies → Original source
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2006-01-01
Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people
56/100 ✓ Peer-reviewed Brain scans and imaging Archives of general psychiatry
Key finding: Atrophy of the hippocampus and amygdala on MRI in cognitively intact elderly people predicts dementia during a 6-year follow-up. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
Cerebral microbleeds on MRI: prevalence, associations, and potential clinical implications
54/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Cerebral microbleeds might indicate a higher risk of future intracerebral hemorrhage and may be a marker of cerebral small-vessel disease and cerebral amyloid angiopathy. +3 more findings
Full summary, score breakdown and related studies → Original source
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