Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,576–19,600 of 27,380 studies, newest first · page 784 of 1096.
March 2012 25
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2012-03-21
A network diffusion model of disease progression in dementia
54/100 ✓ Peer-reviewed Getting a diagnosis Neuron
Key finding: Patterns of dementia are known to fall into dissociated but dispersed brain networks, suggesting that the disease is transmitted along neuronal pathways rather than by proximity. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-03-20
Functional consequences of repeated organophosphate exposure: potential non-cholinergic mechanisms
36/100 ✓ Peer-reviewed Risk factors Pharmacology & therapeutics
Key finding: However, there is now substantial evidence that this canonical (cholinesterase-based) mechanism cannot alone account for the wide-variety of adverse consequences of OP exposure that have been described, especially those associated with repeated exposures to levels that produce no overt signs of acute toxicity. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-20
Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease
72/100 ✓ Peer-reviewed Biomarkers Molecular psychiatry
Key finding: We reported that polymorphisms were associated with plasma Aβ42/Aβ40 ratio (best signal, P=5.4 × 10(-7)). +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-03-16
Hospital transfers of nursing home residents with advanced dementia
52/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: The majority of hospitalizations of NH residents with advanced dementia were due to infections and thus were potentially avoidable, because infections are often treatable in the NH. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-16
TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells
47/100 ✓ Peer-reviewed Brain tissue and pathology The Journal of biological chemistry
Key finding: TDP-43 and FUS localize mainly in the nucleus where they regulate pre-mRNA splicing, but they are also involved in mRNA transport, stability, and translation. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-15
Resting-state fMRI as a biomarker for Alzheimer's disease?
48/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's research & therapy
Key finding: Previous work indicates that resting-state functional magnetic resonance imaging (fMRI) is sensitive to functional brain changes related to Alzheimer's disease (AD) pathology across the clinical spectrum. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-15
Air pollution, oxidative stress, and Alzheimer's disease
40/100 ✓ Peer-reviewed Risk factors Journal of environmental and public health
Key finding: Given the significant prevalence of AP exposure combined with increased population aging, epidemiological evidence for this link is important to consider.
Full summary, score breakdown and related studies → Original source
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2012-03-14
Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease
74/100 ✓ Peer-reviewed Treatments The Cochrane database of systematic reviews
Key finding: Previous Cochrane reviews have considered the use of cholinesterase inhibitors in both Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB). +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-13
Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder
47/100 ✓ Peer-reviewed Hippocampus size on brain scans Translational psychiatry
Key finding: Patients with MDD showed smaller hippocampal volumes and increased inflammatory proteins IL-6 and CRP compared with HC. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-13
A G-rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing
42/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neurochemistry
Key finding: BACE1 pre-mRNA undergoes complex alternative splicing, the regulation of which is not well understood. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-13
Modifiable factors that alter the size of the hippocampus with ageing
50/100 ✓ Peer-reviewed Prevention and risk Nature reviews. Neurology
Key finding: An emerging concept--the dynamic polygon hypothesis--suggests that treatment of modifiable risk factors can increase the volume or prevent atrophy of the hippocampus.
Full summary, score breakdown and related studies → Original source
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2012-03-12
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease
54/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of clinical investigation
Key finding: Receptor for advanced glycation end products (RAGE) mediates Aβ-induced perturbations in cerebral vessels, neurons, and microglia in AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-12
Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study
70/100 ✓ Peer-reviewed How common it is BMJ (Clinical research ed.)
Key finding: Cancer survivors had a lower risk of Alzheimer's disease than those without cancer, and patients with Alzheimer's disease had a lower risk of incident cancer. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-12
Psychosocial care for family caregivers of patients with cancer
68/100 ✓ Peer-reviewed Caregiving Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Key finding: Recommendations for practice include development of standardized guidelines that address caregiver assessment, education, and resources; identification of "caregiver champions" in practice settings; provision of referrals to established support organizations for caregivers (eg, Cancer Support Community, Cancer Care); and collaboration among caregiving, professional, and cancer-related organizations to advocate policy and practice changes for family caregivers.
Full summary, score breakdown and related studies → Original source
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2012-03-09
Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice
36/100 ✓ Peer-reviewed Drug development Pharmacology, biochemistry, and behavior
Key finding: Our results suggest that the db/db mice have multiple AD-like brain changes including impaired cognitive functions, increased phospho-tau and Aβ as well as decreased synaptic proteins.
Full summary, score breakdown and related studies → Original source
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2012-03-09
How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans
64/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurobiology of disease
Key finding: There is evidence that prenatal stress and childhood maltreatment is associated with an abnormally developing HPA system, as well as hippocampal volume reduction. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-09
ACTIVE cognitive training and rates of incident dementia
47/100 ✓ Peer-reviewed Prevention trials Journal of the International Neuropsychological Society : JINS
Key finding: We examined whether cognitive training was associated with reduced rate of incident dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-03-09
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study
67/100 ✓ Peer-reviewed Disparities The Lancet. Neurology
Key finding: In patients with sporadic ALS, we identified the repeat expansion in 236 (7·0%) of 3377 white individuals from the USA, Europe, and Australia, two (4·1%) of 49 black individuals from the USA, and six (8·3%) of 72 Hispanic individuals from the USA.
Full summary, score breakdown and related studies → Original source
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2012-03-09
Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease
56/100 ✓ Peer-reviewed Brain scans and imaging PloS one
Key finding: We performed multi-modal cross-validations for the PET results with ex vivo and in vitro methodologies, including regional brain biodistribution, multi-label digital autoradiography, protein quantification with ELISA, fluorescence microscopy, semi-automated histological quantification and radioligand binding assays. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-09
Association between self-reported dental health status and onset of dementia: a 4-year prospective cohort study of older Japanese adults from the Aichi Gerontological Evaluation Study (AGES) Project
59/100 ✓ Peer-reviewed Prevention and risk Psychosomatic medicine
Key finding: Few teeth without dentures and absence of a regular dentist, not poor mastication and poor attitudes toward dental health, were associated with higher risk of dementia onset in the older Japanese cohort even after adjustment for available covariates. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-08
Long-term declarative memory deficits in diffuse TBI: correlations with cortical thickness, white matter integrity and hippocampal volume
43/100 ✓ Peer-reviewed Hippocampus size on brain scans Cortex; a journal devoted to the study of the nervous system and behavior
Key finding: TBI patients performed significantly worse than controls on all RAVLT measures. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-08
Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients
51/100 ✓ Peer-reviewed Risk factors Dementia and geriatric cognitive disorders
Key finding: A careful clinical evaluation of sleep disorders should be performed routinely in the clinical setting of persons with cognitive decline.
Full summary, score breakdown and related studies → Original source
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2012-03-08
Grief reactions in dementia carers: a systematic review
56/100 ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry
Key finding: Grief in dementia carers can be expected; however, those at risk of distressing anticipatory and complicated grief may be identified and targeted for intervention when necessary.
Full summary, score breakdown and related studies → Original source
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2012-03-06
Diagnostic accuracy of the MMSE in detecting probable and possible Alzheimer's disease in ethnically diverse highly educated individuals: an analysis of the NACC database
50/100 ✓ Peer-reviewed Long-term cohort studies The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: Arch Neurol. 2008;65(7):963-967.) for the Mini-Mental State Examination in detecting cognitive dysfunction in a bilingual sample of highly educated ethnically diverse individuals. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-06
Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type
47/100 ✓ Peer-reviewed Biomarkers Neuroscience
Key finding: Recent evidence indicates that rutin exhibits antioxidant potential and protects the brain against various oxidative stressors. +3 more findings
Full summary, score breakdown and related studies → Original source
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