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54/100

✓ Peer-reviewed alzhub usefulness score 54 out of 100. Mild cognitive impairment

Topic: Amyloid, tau and blood-test diagnosis

The Alzheimer's Disease Neuroimaging Initiative (ADNI) beginning in October 2004, is a 6-year research project that studies changes of cognition, function, brain structure and function, and biomarkers in elderly controls, subjects with mild cognitive impairment, and subjects with Alzheimer's disease (AD). A major goal is to determine and validate MRI, PET images, and cerebrospinal fluid (CSF)/blood biomarkers as predictors and outcomes for use in clinical trials of AD treatments. Structural MRI, FDG PET, C-11 Pittsburgh compound B (PIB) PET, CSF measurements of amyloid beta (Abeta) and species of tau, with clinical/cognitive measurements were performed on elderly controls, subjects with mild cognitive impairment, and subjects with AD. Structural MRI shows high rates of brain atrophy, and has high statistical power for determining treatment effects. FDG PET, C-11 Pittsburgh compound B PET, and CSF measurements of Abeta and tau were significant predictors of cognitive decline and brain atrophy. All data are available at UCLA/LONI/ADNI, without embargo. ADNI-like projects started in Australia, Europe, Japan, and Korea. ADNI provides significant new information concerning the progression of AD.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Weiner, M. W., Aisen, P. S., Jack, C. R., Jagust, W. J., Trojanowski, J. Q., Shaw, L., et al. (2010). The Alzheimer's disease neuroimaging initiative: progress report and future plans. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1016/j.jalz.2010.03.007

Vancouver

Weiner MW, Aisen PS, Jack CR, Jagust WJ, Trojanowski JQ, Shaw L, et al. The Alzheimer's disease neuroimaging initiative: progress report and future plans. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2010. doi:10.1016/j.jalz.2010.03.007. PMID: 20451868.

BibTeX

@article{weiner2010-20451868,
  author  = {Weiner, M. W. and Aisen, P. S. and Jack, C. R. and Jagust, W. J. and Trojanowski, J. Q. and Shaw, L. and Saykin, A. J. and Morris, J. C. and others},
  title   = {{The Alzheimer's disease neuroimaging initiative: progress report and future plans}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2010},
  doi     = {10.1016/j.jalz.2010.03.007},
  pmid    = {20451868},
  url     = {https://doi.org/10.1016/j.jalz.2010.03.007}
}

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Key findings

FDG PET, C-11 Pittsburgh compound B PET, and CSF measurements of Abeta and tau were significant predictors of cognitive decline and brain atrophy.
ADNI provides significant new information concerning the progression of AD.

Why it matters

This progress report describes the Alzheimer's Disease Neuroimaging Initiative, which found that FDG PET, Pittsburgh compound B PET, and CSF measures of amyloid-beta and tau were significant predictors of cognitive decline and brain atrophy. It provides information on disease progression and biomarker validation for trials, not a treatment or cure.

Study details

Evidence strengthLow

How this study scored 54/100

Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 52 of the 96 points we could judge it on, which is 54 out of 100.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2010 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	6 / 7	Cited 600 times (OpenAlex, 2026-10-10)
Citations per year	4 / 5	33.3 citations a year over 18 year(s) since 2010
Impact for its field and year	5 / 6	Cited 28.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	4 / 6	Cited by 39 other studies in this library
Still being cited	3 / 4	Cited 115 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	2 / 3	University of California, Berkeley: institution h-index 2,012 (OpenAlex)
Multicenter collaboration	3 / 3	OpenAlex lists 16 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 20451868)
Free to read	0 / 2	Behind a paywall — scores zero
Points	52 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 52 of the 96 points we could judge it on is 54 out of 100.
Total	54 / 100	—

What each of these 20 components measures, and what this score is not →

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