alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 26,676–26,700 of 27,380 studies, newest first · page 1068 of 1096.

April 1994 7

  1. 1994-04-01

    Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups.

    ✓ Peer-reviewed Getting a diagnosis Journal of Neurology Neurosurgery & Psychiatry

    Key finding: Clinical and neuropathological criteria forfrontotemporal dementia * Early loss of insight into the fact that the altered condition is due to a pathological change of own mental state.

    Full summary, score breakdown and related studies → Original source

  2. 1994-04-01

    Chemical characterization of A beta 17-42 peptide, a component of diffuse amyloid deposits of Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

    Key finding: Brain homogenates were lysed in SDS and submitted to high speed centrifugations. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 1994-04-01

    Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease

    ✓ Peer-reviewed Risk genes beyond APOE Journal of neurology, neurosurgery, and psychiatry

    Key finding: Multiple cortical areas have now been examined from 152 patients (age range 8 weeks-81 years) after a severe head injury with a survival time of between four hours and 2.5 years. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 1994-04-01

    Olfactory deficits in Down subjects: a link with Alzheimer disease

    ✓ Peer-reviewed Down syndrome and Alzheimer's Perceptual and motor skills

    Key finding: Analysis indicated that the adults with Down Syndrome scored worse than the young group on both tasks and that the impairment of the two groups was more pronounced on the matching task.

    Full summary, score breakdown and related studies → Original source

  5. 1994-04-01

    Influence of education and occupation on the incidence of Alzheimer's disease

    ✓ Peer-reviewed How common it is JAMA

    Key finding: The data suggest that increased educational and occupational attainment may reduce the risk of incident AD, either by decreasing ease of clinical detection of AD or by imparting a reserve that delays the onset of clinical manifestations. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 1994-04-01

    In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI

    ✓ Peer-reviewed Brain scans and imaging Biological psychiatry

    Key finding: FDRI values were significantly higher among AD patients in the caudate and globus pallidus. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 1994-04-01

    Apolipoprotein E: risk factor for Alzheimer disease

    ✓ Peer-reviewed Genetics American journal of human genetics

    Key finding: We show that the frequency of this allele among AD patients was significantly higher than that among the control population (.351 vs. .130, P = .000006). +2 more findings

    Full summary, score breakdown and related studies → Original source

March 1994 6

  1. 1994-03-01

    The Cognitive Abilities Screening Instrument (CASI): A Practical Test for Cross-Cultural Epidemiological Studies of Dementia

    ✓ Peer-reviewed Cognitive tests and assessment International Psychogeriatrics

    The Cognitive Abilities Screening Instrument (CASI) has a score range of 0 to 100 and provides quantitative assessment on attention, concentration, orientation, short-term memory, long-term memory, language abilities, visual construction, list-generating fluency, abstraction, and judgment.

    Full summary, score breakdown and related studies → Original source

  2. 1994-03-01

    Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II)

    ✓ Peer-reviewed Brain tissue and pathology Journal of neurochemistry

    Key finding: The concentration of gangliosides--a marker for axodendritic arborization--was reduced to 58-70% of the control concentration in all four gray areas (p < 0.0001) and to 81% in frontal white matter (p < 0.01) of AD type I cases, whereas it was only significantly reduced in temporal cortex (p < 0.01), hippocampus (p < 0.05), and frontal white matter (p < 0.05) in AD type II cases. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 1994-03-01

    A longitudinal study of Alzheimer's disease: measurement, rate, and predictors of cognitive deterioration

    ✓ Peer-reviewed Brain tissue and pathology The American journal of psychiatry

    Key finding: This study measured the annual rate of cognitive change in patients with Alzheimer's disease and determined the effects of clinical variables on that rate. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 1994-03-01

    Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein

    ✓ Peer-reviewed Risk genes beyond APOE The EMBO journal

    Key finding: Abnormal regulation of the metabolism of APP may contribute to the deposition of plaques. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 1994-03-01

    Detection of an Alzheimer disease pattern of cerebral metabolism in Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Dementia (Basel, Switzerland)

    Key finding: Correlational analysis of cerebral metabolic (rCMRglc) data obtained with positron emission tomography (PET) assesses group differences and has demonstrated reduced frontal-parietal rCMRglc interdependencies in Alzheimer's disease (AD). +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 1994-03-01

    Canadian study of health and aging: study methods and prevalence of dementia

    ✓ Peer-reviewed How common it is CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    Key finding: These Canadian estimates of the prevalence of dementia fall toward the upper end of the ranges in other studies, whereas the estimates for Alzheimer's disease fall in the middle of the ranges. +1 more finding

    Full summary, score breakdown and related studies → Original source

February 1994 4

  1. 1994-02-01

    Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter

    ✓ Peer-reviewed Tau biomarkers Clinical chemistry

    Key finding: These findings include the following: (a) reduced cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), the major metabolite of serotonin (5-HT) in drug-free depressed patients; (b) reduced concentrations of 5-HT and 5-HIAA in postmortem brain tissue of depressed and (or) suicidal patients; (c) decreased plasma tryptophan concentrations in depressed patients and a profound relapse in remitted depressed patients who have responded to a serotonergic antidepressant when brain tryptophan availability is reduced; (d) in general, all clinically efficacious antidepressants augment 5-HT neurotransmission following chronic treatment; (e) clinically efficacious antidepressant action by all inhibitors of 5-HT uptake; (f) increases in the density of 5-HT2 binding sites in postmortem brain tissue of depressed patients and suicide victims, as well as in platelets of drug-free depressed patients; (g) decreased number of 5-HT transporter (determined with [3H]imipramine or [3H]paroxetine) binding sites in postmortem brain tissue of suicide victims and depressed patients and in platelets of drug-free depressed patients. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 1994-02-01

    Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype

    ✓ Peer-reviewed Brain tissue and pathology Experimental neurology

    Key finding: We describe a potential metabolic process in individuals who inherit apolipoprotein E-epsilon 4 (APOE4, gene; apoE4, protein) alleles, leading to increased risk and earlier age of onset of late-onset Alzheimer disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 1994-02-01

    [Effect of the chronic treatment with L-acetylcarnitine in Down's syndrome]

    ✓ Peer-reviewed Down syndrome and Alzheimer's La Clinica terapeutica

    Key finding: Neuropsychologic tests were performed in subjects with Down syndrome in order to assess the effect of a 90-day treatment with L-acetyl-carnitine (LAC). +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 1994-02-01

    A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): development and cross-validation

    ✓ Peer-reviewed Getting a diagnosis Psychological medicine

    Key finding: Data from four studies were used to assess the psychometric properties of the 26 IQCODE items. +4 more findings

    Full summary, score breakdown and related studies → Original source

January 1994 8

  1. 1994-01-01

    Developments in the concept of working memory

    ✓ Peer-reviewed Digital health tools Neuropsychology

    Key finding: A simple trace-decay model of the phonological loop provides a coherent account of the effects of word length, phonemic similarity, irrelevant speech, and articulatory suppression in verbal short-term memory tasks. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 1994-01-01

    Morning bright light therapy for sleep and behavior disorders in elderly patients with dementia

    ✓ Peer-reviewed Risk factors Acta Psychiatrica Scandinavica

    Key finding: The measurement of sleep time and the serum melatonin values suggests that sleep and behavior disorders in the dementia group are related to decreases in the amplitude of the sleep-wake rhythm and decreases in the levels of melatonin secretions. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 1994-01-01

    Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties

    ✓ Peer-reviewed Treatments PubMed

    Key finding: Thus, neuroprotection targeting glutamate receptors does apparently not have to be associated with prominent psychotogenicity, and the development and evaluation of new neuroprotective drugs will have to performed in consideration both of the relative safety and of the good clinical effect of the already known and established aminoadamantanes.

    Full summary, score breakdown and related studies → Original source

  4. 1994-01-01

    Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

    ✓ Peer-reviewed Genetics Human Molecular Genetics

    Key finding: We performed these analyses in a sample of late-onset sporadic cases (n = 36) versus controls (n = 38), and in a sample of early-onset sporadic cases (n = 34) versus controls (n = 36). +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 1994-01 month only

    A double-blind, placebo-controlled crossover study of ganglioside GM1 treatment for Alzheimer's disease

    ✓ Peer-reviewed Clinical trials The American journal of psychiatry

    Key finding: GM1 failed to produce significant improvement in patients' cognitive test performance, suggesting that this is not a viable approach to the treatment of cognitive deterioration in Alzheimer's disease.

    Full summary, score breakdown and related studies → Original source

  6. 1994-01-01

    Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders

    ✓ Peer-reviewed Down syndrome and Alzheimer's Acta neuropathologica

    Key finding: In all dementing illnesses, increased microvascular pathology was evident compared to normal controls. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 1994-01-01

    Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA)

    ✓ Peer-reviewed Risk genes beyond APOE Nature genetics

    Key finding: Hereditary dentatorubral-pallidoluysian atrophy (DRPLA) is an autosomal dominant neurologic disorder characterized by variable combinations of myoclonus, epilepsy, cerebellar ataxia, choreoathetosis and dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 1994-01-01

    Cognitive deficits in progressive supranuclear palsy, Parkinson's disease, and multiple system atrophy in tests sensitive to frontal lobe dysfunction

    ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry

    Key finding: Groups of patients with idiopathic Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy or Steele-Richardson-Olszewski syndrome, matched for overall clinical disability, were compared using three computerised cognitive tests previously shown to be sensitive to frontal lobe dysfunction. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →