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Long-term social isolation exacerbates the impairment of spatial working memory in APP/PS1 transgenic mice
Huang HJ, Liang KC, Ke HC, Chang YY, Hsieh-Li HM.. Brain research, 2010-11-26
Topic: Genetics and APOE
The interaction between gene and environment is known to play a major role in the etiology of several neuropsychiatric disorders, including Alzheimer's disease (AD). The present study evaluated whether environmental manipulations such as social isolation may affect the genetic predisposition to accelerate the onset of AD-related symptoms in an adult APP/PS1 double mutant transgenic mouse model. Transgenic and wild-type male mice were housed either singly or in groups from the age of 3 months, and their behavior was compared at 7 months. Isolation had several effects on the APP/PS1 transgenic mice, including exacerbating the impairment of spatial working memory associated with increased Aβ42/Aβ40 ratio in the hippocampus; increased levels of MnSOD in the CA1-CA3 subregions of the hippocampus, basolateral part of the amygdala (BLA), and locus coeruleus (LC); and decreased numbers of cholinergic cells in the diagonal band of Broca (DB), noradrenergic neurons in LC, serotonergic neurons in the Raphe nucleus, and levels of NMDA 2B receptor (NR2B) in the hippocampus region. Our findings demonstrate the susceptibility of APP/PS1 transgenic adult male mice to environmental manipulation and show that social isolation has remarkable effects on the genetically determined AD-like symptoms.
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APA 7th
Huang, H. J., Liang, K. C., Ke, H. C., Chang, Y. Y., & Hsieh-Li, H. M. (2011). Long-term social isolation exacerbates the impairment of spatial working memory in APP/PS1 transgenic mice. Brain research. https://doi.org/10.1016/j.brainres.2010.11.043
Vancouver
Huang HJ, Liang KC, Ke HC, Chang YY, Hsieh-Li HM. Long-term social isolation exacerbates the impairment of spatial working memory in APP/PS1 transgenic mice. Brain research. 2011. doi:10.1016/j.brainres.2010.11.043. PMID: 21114967.
BibTeX
@article{huang2011-21114967,
author = {Huang, H. J. and Liang, K. C. and Ke, H. C. and Chang, Y. Y. and Hsieh-Li, H. M.},
title = {{Long-term social isolation exacerbates the impairment of spatial working memory in APP/PS1 transgenic mice}},
journal = {Brain research},
year = {2011},
doi = {10.1016/j.brainres.2010.11.043},
pmid = {21114967},
url = {https://doi.org/10.1016/j.brainres.2010.11.043}
}
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Key findings
- Isolation had several effects on the APP/PS1 transgenic mice, including exacerbating the impairment of spatial working memory associated with increased Aβ42/Aβ40 ratio in the hippocampus; increased levels of MnSOD in the CA1-CA3 subregions of the hippocampus, basolateral part of the amygdala (BLA), and locus coeruleus (LC); and decreased numbers of cholinergic cells in the diagonal band of Broca (DB), noradrenergic neurons in LC, serotonergic neurons in the Raphe nucleus, and levels of NMDA 2B receptor (NR2B) in the hippocampus region.
- Our findings demonstrate the susceptibility of APP/PS1 transgenic adult male mice to environmental manipulation and show that social isolation has remarkable effects on the genetically determined AD-like symptoms.
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Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 21 of the 58 points we could judge it on, which is 36 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain research) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “app/ps1”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21114967) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 21 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 21 of the 58 points we could judge it on is 36 out of 100. |
| Total | 36 / 100 | — |
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