Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,551–20,575 of 27,380 studies, newest first · page 823 of 1096.
September 2010 25
-
2010-09-23
Severity of dilated Virchow-Robin spaces is associated with age, blood pressure, and MRI markers of small vessel disease: a population-based study
59/100 ✓ Peer-reviewed Risk factors Stroke
Key finding: In this large cohort study of elderly subjects, the degree of dVRS appears independently associated with age, hypertension, volume of white matter hyperintensities, and lacunar infarctions. dVRS should be considered as another MRI marker of cerebral small vessel disease in the elderly with regional variations in their severity. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2010-09-23
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities
56/100 ✓ Peer-reviewed Genetics PLoS genetics
Key finding: However, until recently, variants at few other loci with statistically significant associations have replicated across studies. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2010-09-22
Dementia and cognitive impairment in ESRD: diagnostic and therapeutic strategies
49/100 ✓ Peer-reviewed Prevention and risk Kidney international
Key finding: Dementia is associated with high risks of death, dialysis withdrawal, hospitalization, and disability among patients with ESRD; thus, recognizing and effectively managing cognitive impairment may improve clinical care.
Full summary, score breakdown and related studies → Original source
-
2010-09-20
Memory and communication support in dementia: research-based strategies for caregivers
39/100 ✓ Peer-reviewed Digital health tools International psychogeriatrics
Key finding: Using a knowledge-translation framework, information and strategies can be provided to family and professional caregivers to help them optimize residual memory and communication in people with dementia.
Full summary, score breakdown and related studies → Original source
-
2010-09-20
Effect of an antioxidant drink on homocysteine levels in Alzheimer's patients
58/100 ✓ Peer-reviewed Treatments Journal of the neurological sciences
Key finding: The regular ingestion of polyphenols contained in an antioxidant beverage may decrease tHcy plasmatic concentrations in Alzheimer's patients.
Full summary, score breakdown and related studies → Original source
-
2010-09-19
How common are behavioural changes in amyotrophic lateral sclerosis?
36/100 ✓ Peer-reviewed Caregiving Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Key finding: Our objectives were to assess the frequency of behavioural changes in patients with amyotrophic lateral sclerosis (ALS) and to compare the clinical profile of ALS patients with those with behavioural variant frontotemporal dementia (bvFTD). +3 more findings
Full summary, score breakdown and related studies → Original source
-
2010-09-19
Susac's Syndrome--update
36/100 ✓ Peer-reviewed Risk factors Journal of the neurological sciences
Key finding: This sign is always associated with the clusters of corpus callosum lesions, is especially striking on diffusion weighted imaging, and is associated with long-tract findings.
Full summary, score breakdown and related studies → Original source
-
2010-09-17
BACE1 gene variants do not influence BACE1 activity, levels of APP or Aβ isoforms in CSF in Alzheimer's disease
34/100 ✓ Peer-reviewed Tau biomarkers Molecular neurodegeneration
Key finding: BACE1 is the most important β-secretase responsible for the generation of Alzheimer-associated amyloid β-proteins (Aβ) and may play a role in the amyloidogenic process in AD. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2010-09-16
In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease
47/100 ✓ Peer-reviewed Inflammation and the immune system European journal of nuclear medicine and molecular imaging
Key finding: BPs of [(11)C](R)PK11195 and [(11)C]PIB were significantly higher in the parietotemporal regions of AD patients than in ten healthy controls. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2010-09-16
Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease
47/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of biological chemistry
Key finding: High levels of circulating high density lipoprotein (HDL) and its main protein, apolipoprotein A-I (apoA-I), reduce the risk of cardiovascular disease. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2010-09-16
Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected]
55/100 ✓ Peer-reviewed Risk factors The Lancet. Neurology
Key finding: We found reduced ¹²³I-FP-CIT binding in the striatum (p=0·045) in 17 (40%) of 43 participants compared with 18 controls, and substantia nigra hyperechogenicity in 14 (36%) of 39 participants with IRBD, compared with 16 (11%) of 149 controls (p=0·0002). +4 more findings
Full summary, score breakdown and related studies → Original source
-
2010-09-15
Association between the oxytocin receptor gene and amygdalar volume in healthy adults
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry
Key finding: The present results suggest that OXTR might be associated with the susceptibility to ASD, especially in its aspects of social interaction and communication mediated by a modulation of amygdala development, one of the most distributed brain regions with high density of OXTR. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2010-09-15
Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial
77/100 ✓ Peer-reviewed Clinical safety International journal of geriatric psychiatry
Key finding: Exogenous low dose melatonin administered nightly to elderly patients admitted to acute care may represent a potential protective agent against delirium. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2010-09-15
Effects of ApoE4 and maternal history of dementia on hippocampal atrophy
44/100 ✓ Peer-reviewed Long-term cohort studies Neurobiology of aging
Key finding: MCI subjects with positive maternal history of dementia had smaller hippocampal volumes at baseline and at follow-up, and greater 12-month atrophy rates than subjects with negative maternal history. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2010-09-15
Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction
62/100 ✓ Peer-reviewed Long-term cohort studies International journal of geriatric psychiatry
Key finding: Mild cognitive impairment (MCI) is a syndrome thought to be a prodrome of dementia for some patients. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2010-09-15
Cerebrospinal fluid tau protein levels and 18F-fluorodeoxyglucose positron emission tomography in the differential diagnosis of Alzheimer's disease
38/100 ✓ Peer-reviewed Tau biomarkers Dementia and geriatric cognitive disorders
Key finding: In this study, we aimed to compare cerebrospinal fluid (CSF) levels of total tau (t-tau), phosphorylated tau (p-tau(181)) and positron emission tomography with (18)F-fluorodeoxyglucose (FDG-PET) in the differential diagnosis of Alzheimer's disease (AD) under clinical conditions. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2010-09-15
Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice
42/100 ✓ Peer-reviewed Risk genes beyond APOE Neuroscience
Key finding: Astrocytes are characterized by a high level of intercellular communication mediated by two gap-junction forming proteins, connexin-43 and connexin-30. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2010-09-14
How does diabetes accelerate Alzheimer disease pathology?
36/100 ✓ Peer-reviewed Disease mechanisms Nature reviews. Neurology
Key finding: Diabetes and Alzheimer disease (AD)-two age-related diseases-are both increasing in prevalence, and numerous studies have demonstrated that patients with diabetes have an increased risk of developing AD compared with healthy individuals.
Full summary, score breakdown and related studies → Original source
-
2010-09-13
Dimebon disappointment
38/100 ✓ Peer-reviewed Clinical trials Alzheimer's research & therapy
Key finding: The potential reasons for these disappointing results are discussed, as well as the implication for dimebon and drug treatment in Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
-
2010-09-13
Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition
36/100 ✓ Peer-reviewed Brain scans and imaging Proceedings of the National Academy of Sciences of the United States of America
Key finding: Amyloid-β (Aβ) plaque deposition can precede the clinical manifestations of dementia of the Alzheimer type (DAT) by many years and can be associated with changes in brain metabolism. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2010-09-13
Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes
72/100 ✓ Peer-reviewed Getting a diagnosis Archives of neurology
Key finding: Reductions in cerebral glucose metabolic rate (CMRglu) as measured by fludeoxyglucose F 18-positron emission tomography (FDG-PET) in parietotemporal, frontal, and cingulate cortices are associated with increased AD risk and can be observed years before dementia onset. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2010-09-13
A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease
70/100 ✓ Peer-reviewed Treatments Archives of neurology
Key finding: Pioglitazone was generally well tolerated in this pilot study. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2010-09-10
Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy
66/100 ✓ Peer-reviewed Caregiving Dementia and geriatric cognitive disorders
Key finding: NPTs emerge as a useful, versatile and potentially cost-effective approach to improve outcomes and QoL in ADRD for both the PWD and CG. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2010-09-09
Fractionating verbal episodic memory in Alzheimer's disease
36/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage
Key finding: However, a more recent work, derived in part from functional neuroimaging studies, has suggested that other brain structures make up a large-scale network that appears to support successful encoding and retrieval of episodic memories. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2010-09-08
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial
78/100 ✓ Peer-reviewed Risk factors PloS one
Key finding: The mean rate of brain atrophy per year was 0.76% [95% CI, 0.63-0.90] in the active treatment group and 1.08% [0.94-1.22] in the placebo group (P = 0.001). +1 more finding
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →