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A new proposal for randomized start design to investigate disease-modifying therapies for Alzheimer disease
Zhang RY, Leon AC, Chuang-Stein C, Romano SJ.. Clinical trials (London, England), 2011-02-01
Topic: Amyloid, tau and blood-test diagnosis
Results The greatest advantage of the RSD proposed in this article is its ability to critically address the question on a DM effect.
Key findings
- Results The greatest advantage of the RSD proposed in this article is its ability to critically address the question on a DM effect.
Why it matters
This paper proposes a new trial design for studying whether a treatment modifies the course of Alzheimer's disease. It is a methodological proposal and reports no treatment results.
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Study details
- Study designlongitudinal study
- Participants1,000
- Evidence strengthHigh
How this study scored 50/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Clinical trials (London, England)) |
| Journal's citation record | 1 / 4 | Clinical Trials: journal h-index 93 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,000 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | 3 / 7 | Cited 21 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.2 citations a year over 17 year(s) since 2011 |
| Impact for its field and year | 2 / 6 | Cited 1.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Steven J. Romano: h-index 21 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Weill Cornell Medicine: institution h-index 1,163 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21335586) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription Unpaywall, Europe PMC and OpenAlex found no free copy of the full text (checked 10 Oct 2026), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Zhang, R. Y., Leon, A. C., Chuang-Stein, C., & Romano, S. J. (2011). A new proposal for randomized start design to investigate disease-modifying therapies for Alzheimer disease. Clinical trials (London, England). https://doi.org/10.1177/1740774510392255
Vancouver
Zhang RY, Leon AC, Chuang-Stein C, Romano SJ. A new proposal for randomized start design to investigate disease-modifying therapies for Alzheimer disease. Clinical trials (London, England). 2011. doi:10.1177/1740774510392255. PMID: 21335586.
BibTeX
@article{zhang2011-21335586,
author = {Zhang, R. Y. and Leon, A. C. and Chuang-Stein, C. and Romano, S. J.},
title = {{A new proposal for randomized start design to investigate disease-modifying therapies for Alzheimer disease}},
journal = {Clinical trials (London, England)},
year = {2011},
doi = {10.1177/1740774510392255},
pmid = {21335586},
url = {https://doi.org/10.1177/1740774510392255}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.