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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 17,451–17,475 of 27,380 studies, newest first · page 699 of 1096.

December 2014 24

  1. 2014-12-08

    The role of protein clearance mechanisms in organismal ageing and age-related diseases

    ✓ Peer-reviewed Disease mechanisms Nature communications

    Key finding: Modulation of either proteasome activity or autophagic-lysosomal potential extends lifespan and protects organisms from symptoms associated with proteostasis disorders, suggesting that protein clearance mechanisms are directly linked to ageing and age-associated diseases.

    Full summary, score breakdown and related studies → Original source

  2. 2014-12-08

    Nothing to complain about? Residents' and relatives' views on a "good life" and ethical challenges in nursing homes

    ✓ Peer-reviewed End-of-life care Nursing ethics

    Key finding: Residents and relatives experience ethical challenges in Norwegian nursing homes, mostly connected to "everyday ethical issues." +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2014-12-08

    A Comprehensive Profile of ChIP-Seq-Based PU.1/Spi1 Target Genes in Microglia

    ✓ Peer-reviewed TREM2 and immune genetics Gene regulation and systems biology

    Key finding: Microglia, rapidly activated in response to proinflammatory stimuli, are accumulated in brain lesions of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2014-12-07

    Retinal fluorescence lifetime imaging ophthalmoscopy measures depend on the severity of Alzheimer's disease

    ✓ Peer-reviewed Tau biomarkers Acta ophthalmologica

    Key finding: FLIO set-up uses a scanning laser ophthalmoscope (HRA2, Heidelberg Engineering, Germany), which was modified by the use of an excitation pulse laser BLD440 (Becker&Hickl, Berlin, Germany) and detection of fluorescence lifetime by time-correlated single photon counting (TCSPC; Becker&Hickl) in two spectral channels (channel 1: 490-560 nm, channel 2: 560-700 nm). +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2014-12-05

    Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

    ✓ Peer-reviewed Genetics Genome biology

    In comparative high-throughput sequencing assays, a fundamental task is the analysis of count data, such as read counts per gene in RNA-seq, for evidence of systematic changes across experimental conditions.

    Full summary, score breakdown and related studies → Original source

  6. 2014-12-04

    Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

    ✓ Peer-reviewed Disease mechanisms Experimental neurology

    Key finding: These findings suggest that increasing plasticity by manipulation of perineuronal nets offers a novel therapeutic approach to the treatment of memory loss in neurodegenerative disorders.

    Full summary, score breakdown and related studies → Original source

  7. 2014-12-04

    Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's PloS one

    Key finding: Interestingly, changes in synaptic plasticity and behavior were not observed in the JZL184-treated 2N mice suggesting that the treatment specifically attenuated the defects in the trisomic animals. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2014-12-03

    Deep Brain Stimulation Influences Brain Structure in Alzheimer's Disease

    ✓ Peer-reviewed Hippocampus size on brain scans Brain stimulation

    Key finding: We present the first in-human evidence that, in addition to modulating neural circuit activity, DBS may influence the natural course of brain atrophy in a neurodegenerative disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2014-12-03

    Olfactory deficits predict cognitive decline and Alzheimer dementia in an urban community

    ✓ Peer-reviewed Prevention and risk Neurology

    Key finding: The findings support the cross-cultural use of a relatively inexpensive odor identification test as an early biomarker of cognitive decline and AD dementia.

    Full summary, score breakdown and related studies → Original source

  10. 2014-12-02

    Advance care planning for older people in Australia presenting to the emergency department from the community or residential aged care facilities

    ✓ Peer-reviewed End-of-life care Health & social care in the community

    Key finding: Overall prevalence of ACP was 13.3% (n = 40/300); over one-quarter (26.6%, n = 40/150) of those presenting to the ED from residential aged care had a documented Advance Care Plan, compared to none (0%, n = 0/150) of the people from the community. +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2014-12-01

    Intravenous immunoglobulin for Alzheimer's disease

    ✓ Peer-reviewed Treatments Clinical & Experimental Immunology

    Key finding: Initial studies suggested that IVIg contained antibodies against monomeric forms of Aβ 5. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2014-12 month only

    Genome-wide association studies in neurology

    ✓ Peer-reviewed Genetics Annals of translational medicine

    Key finding: We then discuss the present and future implications of these findings with regards to disease prediction, uncovering basic biology, and the development of potential therapeutic agents.

    Full summary, score breakdown and related studies → Original source

  13. 2014-12-01

    Persistence and adherence with dementia pharmacotherapy: relevance of patient, provider, and system factors

    ✓ Peer-reviewed Digital health tools Canadian journal of psychiatry. Revue canadienne de psychiatrie

    Key finding: This paper provides a comprehensive review of studies examining adherence and (or) persistence with dementia pharmacotherapy during the past decade, including a summary of the key patient-, drug-, system-, and provider-level factors associated with these measures. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2014-12-01

    Anosognosia in Alzheimer's disease: diagnosis, frequency, mechanism and clinical correlates

    ✓ Peer-reviewed Caregiving Cortex; a journal devoted to the study of the nervous system and behavior

    Key finding: Anosognosia in AD is a significant predictor of apathy and is significantly related to lower depression and anxiety scores, more severe caregiver burden and dangerous behaviours. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2014-12-01

    New concepts in nutraceuticals as alternative for pharmaceuticals

    ✓ Peer-reviewed Brain scans and imaging International journal of preventive medicine

    Key finding: Recent studies have shown promising results for these compounds in various complications.

    Full summary, score breakdown and related studies → Original source

  16. 2014-12-01

    Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers

    ✓ Peer-reviewed Biomarkers JAMA neurology

    Key finding: This biomarker discrepancy is likely due to overexpression of amyloid precursor protein in the transformed cellular models. +2 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2014-12-01

    Management of chronic heart failure in the older population

    ✓ Peer-reviewed End-of-life care Journal of geriatric cardiology : JGC

    Key finding: Chronic heart failure (CHF) is the leading cause of hospitalization for those over the age of 65 and represents a significant clinical and economic burden. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2014-12-01

    Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death

    ✓ Peer-reviewed Lewy body dementia Neuron

    Key finding: Expanded GGGGCC (G4C2) nucleotide repeats within the C9ORF72 gene are the most common genetic mutation associated with both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

    Full summary, score breakdown and related studies → Original source

  19. 2014-12-01

    Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer disease

    ✓ Peer-reviewed Risk factors JAMA neurology

    Key finding: Patients with moderate to severe AD presented with higher mean (SD) orexin levels compared with controls (154.36 [28.16] vs 131.03 [26.55]; P Conclusions and relevance Our results demonstrate that, in AD, increased cerebrospinal fluid orexin levels are related to a parallel sleep deterioration, which appears to be associated with cognitive decline. +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2014-12-01

    Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury

    ✓ Peer-reviewed Risk factors The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: These findings suggest that chronic impairment of glymphatic pathway function after TBI may be a key factor that renders the post-traumatic brain vulnerable to tau aggregation and the onset of neurodegeneration.

    Full summary, score breakdown and related studies → Original source

  21. 2014-12-01

    Management of cognitive determinants in senile dementia of Alzheimer's type: therapeutic potential of a novel polyherbal drug product

    ✓ Peer-reviewed Digital health tools Clinical drug investigation

    Key finding: The trial was performed in 109 healthy subjects and 123 SDAT patients of whom 97 healthy subjects and 104 SDAT patients completed the study. +1 more finding

    Full summary, score breakdown and related studies → Original source

  22. 2014-12-01

    Diabetes in midlife and cognitive change over 20 years: a cohort study

    ✓ Peer-reviewed Prevention and risk Annals of internal medicine

    Key finding: Diabetes prevention and glucose control in midlife may protect against late-life cognitive decline. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2014-12-01

    Dementia risk after traumatic brain injury vs nonbrain trauma: the role of age and severity

    ✓ Peer-reviewed Prevention and risk JAMA neurology

    Key finding: Of these, 4361 (8.4%) developed dementia compared with 6610 patients with NTT (5.9%) (P Conclusions and relevance Among patients evaluated in the ED or inpatient settings, those with moderate to severe TBI at 55 years or older or mild TBI at 65 years or older had an increased risk of developing dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2014-12-01

    The diagnosis and management of mild cognitive impairment: a clinical review

    ✓ Peer-reviewed Prevention and risk JAMA

    Key finding: The prevalence of MCI in adults aged 65 years and older is 10% to 20%; risk increases with age and men appear to be at higher risk than women. +1 more finding

    Full summary, score breakdown and related studies → Original source

November 2014 1

  1. 2014-11-29

    Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

    ✓ Peer-reviewed Risk genes beyond APOE Acta neuropathologica

    Key finding: However, postnatal lethality of double knockout mice has so far precluded the analysis of the physiological functions of APP and the APLPs in the brain. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →