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56/100

✓ Peer-reviewed alzhub usefulness score 56 out of 100. Brain tissue and pathology

Topic: Amyloid, tau and blood-test diagnosis

Neuropsychiatric symptoms (NPS) are core features of Alzheimer's disease and related dementias. Once thought to emerge primarily in people with late-stage disease, these symptoms are currently known to manifest commonly in very early disease and in prodromal phases, such as mild cognitive impairment. Despite decades of research, reliable treatments for dementia-associated NPS have not been found, and those that are in widespread use present notable risks for people using these medications.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Lyketsos, C. G., Carrillo, M. C., Ryan, J. M., Khachaturian, A. S., Trzepacz, P., Amatniek, J., et al. (2011). Neuropsychiatric symptoms in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1016/j.jalz.2011.05.2410

Vancouver

Lyketsos CG, Carrillo MC, Ryan JM, Khachaturian AS, Trzepacz P, Amatniek J, et al. Neuropsychiatric symptoms in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2011. doi:10.1016/j.jalz.2011.05.2410. PMID: 21889116.

BibTeX

@article{lyketsos2011-21889116,
  author  = {Lyketsos, C. G. and Carrillo, M. C. and Ryan, J. M. and Khachaturian, A. S. and Trzepacz, P. and Amatniek, J. and Cedarbaum, J. and Brashear, R. and others},
  title   = {{Neuropsychiatric symptoms in Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2011},
  doi     = {10.1016/j.jalz.2011.05.2410},
  pmid    = {21889116},
  url     = {https://doi.org/10.1016/j.jalz.2011.05.2410}
}

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Key findings

Once thought to emerge primarily in people with late-stage disease, these symptoms are currently known to manifest commonly in very early disease and in prodromal phases, such as mild cognitive impairment.
Despite decades of research, reliable treatments for dementia-associated NPS have not been found, and those that are in widespread use present notable risks for people using these medications.
An Alzheimer's Association Research Roundtable was convened in the spring of 2010 to review what is known about NPS in Alzheimer's disease, to discuss classification and underlying neuropathogenesis and vulnerabilities, and to formulate recommendations for new approaches to tailored therapeutics.

Why it matters

This review states that neuropsychiatric symptoms are core features of Alzheimer's disease and can appear very early, including in mild cognitive impairment, but that reliable treatments for these symptoms have not been found and widely used medications carry notable risks. It offers no treatment, cure or prevention for Alzheimer's disease itself.

Study details

Evidence strengthLow

How this study scored 56/100

Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2011 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	7 / 7	Cited 1,132 times (OpenAlex, 2026-10-10)
Citations per year	5 / 5	66.6 citations a year over 17 year(s) since 2011
Impact for its field and year	4 / 6	Cited 15.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	4 / 6	Cited by 31 other studies in this library
Still being cited	4 / 4	Cited 319 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author David Scott Miller: h-index 93 (OpenAlex, whole career)
Institution's track record	2 / 3	Johns Hopkins University: institution h-index 2,306 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 8 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 21889116)
Free to read	0 / 2	Behind a paywall — scores zero
Total	56 / 100	—

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