alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 26,101–26,125 of 27,380 studies, newest first · page 1045 of 1096.

August 1997 10

  1. 1997-08-27

    [Sleep disorders and dementia]

    ✓ Peer-reviewed Risk factors Praxis

    Key finding: Whether recent reports on efficacy of melatonin in elderly insomniacs also apply to demented patients is yet uncertain. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 1997-08-01

    Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease

    ✓ Peer-reviewed Cognitive tests and assessment Journal of neuropathology and experimental neurology

    Key finding: Average synaptophysin levels were reduced in hippocampus when comparing definite AD to controls (55%, p < 0.0001), p-AD to control (25%, p < 0.005), and definite AD to p-AD (30%, p < 0.05), but levels in entorhinal cortex, occipital cortex, and caudate nucleus were either unchanged or less significantly altered than in hippocampus. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 1997-08-01

    Clinical heterogeneity and prognosis in combined methylmalonic aciduria and homocystinuria (cblC)

    ✓ Peer-reviewed Clinical safety Journal of inherited metabolic disease

    Key finding: The clbC form of methylmalonic acidaemia is a rare and poorly understood condition which results from impaired biosynthesis of methylcobalamin and adenosylcobalamin. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 1997-08-01

    Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression

    ✓ Peer-reviewed Risk genes beyond APOE Journal of neuropathology and experimental neurology

    Key finding: The main objectives of the present study were to determine which GT subtype is most affected in AD and to asses to what extent altered GT function is associated with abnormal amyloid precursor protein (APP) expression. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 1997-08-01

    Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E

    ✓ Peer-reviewed Risk genes beyond APOE Nature

    Key finding: Inflammatory events may also contribute to Alzheimer's disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 1997-08-01

    Medial temporal structures relate to memory impairment in Alzheimer's disease: an MRI volumetric study

    ✓ Peer-reviewed Brain scans and imaging Journal of neurology, neurosurgery, and psychiatry

    Key finding: The presence of perihippocampal damage involving the amygdala proper, its surrounding cortex, and the subiculum further increased the severity of memory impairment attributable to hippocampal damage in Alzheimer's disease.

    Full summary, score breakdown and related studies → Original source

  7. 1997-08-01

    Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: implications for cerebral amyloid angiopathy

    ✓ Peer-reviewed Genetics Laboratory investigation; a journal of technical methods and pathology

    Key finding: The accumulation of intracellular Abeta was enhanced by chloroquine and blocked by cycloheximide and brefeldin A and pretreatment with trypsin, suggesting that the internalization of Abeta occurs by receptor-mediated endocytosis.

    Full summary, score breakdown and related studies → Original source

  8. 1997-08-01

    Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development

    ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Apolipoprotein E (apoE) is associated with several classes of plasma lipoproteins and mediates uptake of lipoproteins through its ability to interact with specific cell surface receptors. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 1997-08-01

    Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis

    ✓ Peer-reviewed Genetics The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Endosomal enlargement contributed to an average 2.5-fold larger total endosomal volume per neuron, implying a marked increase in endocytic activity. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 1997-08-01

    Distinctive pattern of Bergmann glial pathology in human hepatic encephalopathy

    ✓ Peer-reviewed Biomarkers Molecular and chemical neuropathology

    Key finding: However, a previous study in the portacaval shunted rat, a model of hepatic encephalopathy, revealed increased rather than decreased GFAP immunoreactivity in Bergmann glia, a specialized group of cerebellar astrocytes. +2 more findings

    Full summary, score breakdown and related studies → Original source

July 1997 15

  1. 1997-07-09

    Brain Infarction and the Clinical Expression of Alzheimer Disease-Reply

    ✓ Peer-reviewed Vascular contributions JAMA

    In Reply. —The analyses of Drs Mirra and Gearing indicate that brain infarcts are not associated with NFTs in the neocortex.

    Full summary, score breakdown and related studies → Original source

  2. 1997-07-01

    Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β‐Peptide: Role of the Lipid Peroxidation Product 4‐Hydroxynonenal

    ✓ Peer-reviewed Disease mechanisms Journal of Neurochemistry

    Key finding: Synapse loss is closely correlated with cognitive impairments in Alzheimer's disease, suggesting that the synapse may be the site at which degenerative mechanisms are initiated and propagated. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 1997-07-01

    Association of human, rat, and rabbit apolipoprotein E with beta-amyloid

    ✓ Peer-reviewed Genetics Journal of neuroscience research

    Key finding: Using native preparations of apoE from conditioned tissue culture media or plasma lipoproteins, we have previously shown that when equivalent amounts of apoE3 or E4 were incubated with beta-amyloid (A beta), apoE3 formed 20 times as much SDS-stable complex with the peptide as apoE4.

    Full summary, score breakdown and related studies → Original source

  4. 1997-07-01

    Diagnostic criteria for neuropathologic assessment of Alzheimer's disease

    ✓ Peer-reviewed Getting a diagnosis Neurobiology of aging

    Key finding: Prior to any evaluation of morphologic brain changes, a decision must be made whether a given alteration is associated with aging or with disease.

    Full summary, score breakdown and related studies → Original source

  5. 1997-07-01

    Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis

    ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Oxidative stress is believed to play important roles in neuronal cell death associated with many different neurodegenerative conditions (e.g., Alzheimer's disease, Parkinson's disease, and cerebral ischemia), and it is believed also that apoptosis is an important mode of cell death in these disorders. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 1997-07-01

    Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons

    ✓ Peer-reviewed Drug development FEBS letters

    Key finding: However, the implicated protein kinases are still unknown. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 1997-07-01

    Hippocampal volume in women victimized by childhood sexual abuse

    ✓ Peer-reviewed Hippocampus size on brain scans Psychological medicine

    Key finding: These findings, which are generally consistent with prior reports of reduced hippocampal volume in combat veterans with PTSD, suggest that diminished hippocampal size may be either a consequence of trauma exposure or a risk factor for the development of psychiatric complications following trauma exposure. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 1997-07-01

    Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories

    ✓ Peer-reviewed Brain tissue and pathology Neurobiology of Aging

    Key finding: Initial amyloid deposits develop in poorly myelinated areas of the basal neocortex, spread into adjoining areas and the hippocampus, and eventually infiltrate all cortical areas, including densely myelinated primary fields of the neocortex. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 1997-07-01

    Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease

    ✓ Peer-reviewed Brain tissue and pathology Neurobiology of Aging

    Key finding: This report summarizes the consensus recommendations of a panel of neuropathologists from the United States and Europe to improve the postmortem diagnostic criteria for Alzheimer’s disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 1997-07-01

    PROFILING THE CARE NEEDS OF THE POPULATION WITH DEMENTIA: A SURVEY IN CENTRAL SCOTLAND

    ✓ Peer-reviewed Health systems and care delivery International Journal of Geriatric Psychiatry

    Key finding: Identified population, pro-rating for identifiable non-response, accounted for 78% of EURODEM prevalence. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 1997-07-01

    Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease

    ✓ Peer-reviewed Brain tissue and pathology Neurology

    Key finding: However, the molecular and cellular mechanisms by which APOE epsilon 4 renders AD risk are unclear. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 1997-07-01

    Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America

    Key finding: To elucidate the molecular mechanism of this effect, wild-type (wt) or mutant PS1 and PS2 genes were stably transfected into Chinese hamster ovary cells expressing endogenous or transfected beta-amyloid precursor protein (APP). +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 1997-07-01

    Assessment of digital EEG, quantitative EEG, and EEG brain mapping: report of the American Academy of Neurology and the American Clinical Neurophysiology Society [RETIRED]

    ✓ Peer-reviewed Digital health tools Neurology

    Key finding: (Class II and III evidence, Type D recommendation). +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 1997-07-01

    Prevalence of dementia in a rural setting: A report from India

    ✓ Peer-reviewed Disparities International journal of geriatric psychiatry

    Key finding: The difficulties associated with the use of the GMS in a non-literature rural population are discussed. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 1997-07-01

    Incidence and prevalence of dementia in a multiethnic cohort of municipal retirees

    ✓ Peer-reviewed Disparities Neurology

    Key finding: Risk of dementia by age 80 was more pronounced for Hispanic and black men compared with white men. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →