Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,876–19,900 of 27,380 studies, newest first · page 796 of 1096.
October 2011 20
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2011-10-03
Barriers and facilitators to the receipt of palliative care for people with dementia: the views of medical and nursing staff
43/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: Four themes were identified: Making the transition; Competence challenged; 'The long view' and Working together. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-03
Risk of Continued Institutionalization After Hospitalization in Older Adults
62/100 ✓ Peer-reviewed Risk factors The Journals of Gerontology Series A
Key finding: From 1996 through 2008, 5.55% of hospitalized patients resided in a nursing home 6 months later compared with 0.54% of nonhospitalized control patients. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-03
Screening utility of the Montreal Cognitive Assessment (MoCA): in place of--or as well as--the MMSE?
45/100 ✓ Peer-reviewed Cognitive tests and assessment International psychogeriatrics
Key finding: This aim of this study was to assess the clinical utility of the Montreal Cognitive Assessment (MoCA) as a screening instrument for cognitive impairment in patients referred to a memory clinic, alone and in combination with the Mini-Mental State Examination (MMSE). +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-02
Gait and cognition: the relationship between gait stability and variability with executive function in persons with and without dementia
36/100 ✓ Peer-reviewed Digital health tools Gait & posture
Key finding: Patients with dementia exhibited a significantly (p<.05) less variable, but more irregular trunk acceleration pattern than cognitively intact elderly on single and dual task walking. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-01
The heterogeneity of “major depression”
40/100 ✓ Peer-reviewed Risk factors World Psychiatry
Key finding: They concluded that their results “challenge our understanding of major depression as a homogeneous categorical entity”. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-01
Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics
36/100 ✓ Peer-reviewed Prevention and risk Journal of cellular physiology
Key finding: Analysis of the 2.5 kb human EAAT2 promoter showed that NF-κB is an important regulator of EAAT2 expression in astrocytes.
Full summary, score breakdown and related studies → Original source
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2011-10-01
Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies
36/100 ✓ Peer-reviewed Drug development Archives of neurology
Key finding: However, the results of work on this topic are inconsistent: some studies find beneficial effects, but other studies do not.
Full summary, score breakdown and related studies → Original source
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2011-10-01
Quality of Care Provided in a Special Needs Plan Using a Nurse Care Manager Model
35/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society
Key finding: Based on physician medical records alone, the 231 high-risk participants (mean age 77, 67% women) received recommended care for 53% of 5,569 evaluated clinical circumstances, ranging from 12% for end-of-life care to 78% for diabetes mellitus. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-01
Exploring the maze of the cognition-audition connection
31/100 ✓ Peer-reviewed Risk factors The Hearing Journal
Key finding: What do we know? Figure: Douglas BeckEdwards: Our research has primarily addressed the effect of hearing aid technology on “cognitive load.” +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-01
The seeds of neurodegeneration: prion-like spreading in ALS
53/100 ✓ Peer-reviewed Brain tissue and pathology Cell
Key finding: Evidence for such a prion-like mechanism has now spread to the main misfolded proteins, SOD1 and TDP-43, implicated in amyotrophic lateral sclerosis (ALS). +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-10-01
What genetics tells us about the causes and mechanisms of Parkinson's disease
51/100 ✓ Peer-reviewed Brain tissue and pathology Physiological reviews
Key finding: It is due to the progressive degeneration of the dopaminergic neurons of the substantia nigra and is accompanied by the appearance of intraneuronal inclusions enriched in α-synuclein, the Lewy bodies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-01
Human Alzheimer and inflammation biomarkers after anesthesia and surgery
44/100 ✓ Peer-reviewed Tau biomarkers Anesthesiology
Key finding: The prevalence of postoperative cognitive disturbance, coupled with growing in vitro, cell, and animal evidence suggesting anesthetic effects on neurodegeneration, calls for additional study of the interaction between surgical care and Alzheimer neuropathology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-01
Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders
51/100 ✓ Peer-reviewed Lewy body dementia Annals of neurology
Key finding: Pathologic similarities with prion disease suggest that the formation and spread of these proteinaceous lesions might involve a common molecular mechanism-corruptive protein templating.
Full summary, score breakdown and related studies → Original source
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2011-10-01
Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death
56/100 ✓ Peer-reviewed Lewy body dementia Neuron
Key finding: Here, we demonstrate that preformed fibrils generated from full-length and truncated recombinant α-syn enter primary neurons, probably by adsorptive-mediated endocytosis, and promote recruitment of soluble endogenous α-syn into insoluble PD-like LBs and LNs. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-01
The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's disease
71/100 ✓ Peer-reviewed Risk factors Movement disorders : official journal of the Movement Disorder Society
Key finding: As none of the studies exceeded a duration of 6 months, the recommendations given are for the short-term management of the different non-motor symptoms. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-01
The comprehensive process model of engagement
40/100 ✓ Peer-reviewed Digital health tools The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Personal attributes, environmental factors, and stimulus characteristics all contribute to the level and nature of engagement, with a secondary finding being that exposure to any stimulus elicits engagement in persons with dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-01
Relationship between education and dementia: an updated systematic review
63/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer disease and associated disorders
Key finding: Lower education was associated with a greater risk for dementia in many but not all studies. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-01
Psychiatric complications of treatment with corticosteroids: review with case report
44/100 ✓ Peer-reviewed Prevention and risk Psychiatry and clinical neurosciences
Key finding: Corticosteroids are widely used in modern medicine but can result in troubling psychiatric side-effects. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-01
Long-term consequences of repetitive brain trauma: chronic traumatic encephalopathy
48/100 ✓ Peer-reviewed Prevention and risk PM & R : the journal of injury, function, and rehabilitation
Key finding: CTE results in a progressive decline of memory and cognition, as well as depression, suicidal behavior, poor impulse control, aggressiveness, parkinsonism, and, eventually, dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-01
Hippocampal sclerosis in the elderly: genetic and pathologic findings, some mimicking Alzheimer disease clinically
45/100 ✓ Peer-reviewed Genetics Alzheimer disease and associated disorders
Key finding: TDP-43 pathology was more frequent in cases with HpScl compared with those without HpScl (89% vs. 24%). +4 more findings
Full summary, score breakdown and related studies → Original source
September 2011 5
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2011-09-30
Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations
36/100 ✓ Peer-reviewed Biomarkers Biochemistry
Key finding: Missense mutations in presenilin are associated with early-onset familial AD, and these mutations generally both decrease Aβ production and increase the ratio of the aggregation-prone 42-residue form (Aβ42) to the 40-residue form (Aβ40). +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-30
NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy
36/100 ✓ Peer-reviewed Disease mechanisms Human molecular genetics
Key finding: Here, we show that overexpression of NMNAT significantly suppresses both behavioral and morphological deficits associated with tauopathy by means of reducing the levels of hyperphosphorylated tau oligomers. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-09-30
Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of biological chemistry
Key finding: These results suggest a direct link between Dyrk1A and RCAN1 in the Caln-NFAT signaling and Tau hyperphosphorylation pathways, supporting the notion that the synergistic interaction between the chromosome 21 genes RCAN1 and Dyrk1A is associated with a variety of pathological features associated with DS.
Full summary, score breakdown and related studies → Original source
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2011-09-29
The genetics of the human APOE polymorphism
40/100 ✓ Peer-reviewed Genetics Rejuvenation research
Key finding: The genetic origin of the three common variants of the human apolipoprotein E (apoE) protein, known as E2, E3 and E4, was understood in 1981, and since the mid 1980s these are probably the most-studied protein variants in human races.
Full summary, score breakdown and related studies → Original source
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2011-09-28
Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Mammalian genome : official journal of the International Mammalian Genome Society
Key finding: Ts65Dn is a mouse model of Down syndrome: a syndrome that results from chromosome (Chr) 21 trisomy and is associated with congenital defects, cognitive impairment, and ultimately Alzheimer's disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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