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Progression from mild to pronounced MCI is not associated with cerebrospinal fluid biomarker deviations
Wallin A, Göthlin M, Gustavsson M, Zetterberg H, Eckerström C, Blennow K, Edman A, Lind K et al.. Dementia and geriatric cognitive disorders, 2011-11-03
Topic: Brain proteins, microglia and lab models
Background/aim Detection of cerebrospinal fluid (CSF) biomarker deviations improve prediction of progression from mild cognitive impairment (MCI) to dementia. However, it is not settled whether the same pattern exists in patients progressing from very mild to more pronounced MCI. Given that neurodegenerative processes occur very early in the disease course, we also expected to find biomarker deviations in these patients.
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APA 7th
Wallin, A., Göthlin, M., Gustavsson, M., Zetterberg, H., Eckerström, C., Blennow, K., et al. (2011). Progression from mild to pronounced MCI is not associated with cerebrospinal fluid biomarker deviations. Dementia and geriatric cognitive disorders. https://doi.org/10.1159/000333034
Vancouver
Wallin A, Göthlin M, Gustavsson M, Zetterberg H, Eckerström C, Blennow K, et al. Progression from mild to pronounced MCI is not associated with cerebrospinal fluid biomarker deviations. Dementia and geriatric cognitive disorders. 2011. doi:10.1159/000333034. PMID: 22057225.
BibTeX
@article{wallin2011-22057225,
author = {Wallin, A. and Göthlin, M. and Gustavsson, M. and Zetterberg, H. and Eckerström, C. and Blennow, K. and Edman, A. and Lind, K. and others},
title = {{Progression from mild to pronounced MCI is not associated with cerebrospinal fluid biomarker deviations}},
journal = {Dementia and geriatric cognitive disorders},
year = {2011},
doi = {10.1159/000333034},
pmid = {22057225},
url = {https://doi.org/10.1159/000333034}
}
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Key findings
- However, it is not settled whether the same pattern exists in patients progressing from very mild to more pronounced MCI.
- Given that neurodegenerative processes occur very early in the disease course, we also expected to find biomarker deviations in these patients.
- Methods A total of 246 memory clinic patients with non-progressive (n = 161), progressive (n = 19), or converting (n = 66) MCI, 67 with stable dementia, and 80 controls were followed for 24 months.
- At baseline, CSF total tau (T-tau), β-amyloid 1-42 (Aβ42) and the light subunit of neurofilament protein (NFL) were determined.
Why it matters
This study followed patients with mild cognitive impairment for 24 months and found that progression from very mild to more pronounced MCI was not associated with deviations in spinal fluid biomarkers. The authors had expected to find such deviations, but the results did not support that expectation.
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Study details
- Participants161
- Evidence strengthLow
How this study scored 34/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Dementia and geriatric cognitive disorders) |
| Journal's citation record | 1 / 4 | Dementia and Geriatric Cognitive Disorders: journal h-index 149 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 161 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 14 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.8 citations a year over 17 year(s) since 2011 |
| Impact for its field and year | 2 / 6 | Cited 1.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Sindre Rolstad: h-index 27 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Gothenburg: institution h-index 972 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 22057225) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 34 / 100 | — |
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