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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 7,326–7,350 of 27,380 studies, newest first · page 294 of 1096.

September 2023 25

  1. 2023-09-25

    No association between metformin initiation and incident dementia in older adults newly diagnosed with diabetes

    ✓ Peer-reviewed Prevention and risk Journal of Internal Medicine

    Key finding: Early metformin initiation was not associated with incident dementia in older adults newly diagnosed with diabetes. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2023-09-24

    Anti-Amyloid Therapies for Alzheimer's Disease and the Amyloid Cascade Hypothesis

    ✓ Peer-reviewed Treatments International journal of molecular sciences

    Key finding: However, as reviewed in this article, results from the numerous clinical trials that have tested anti-Aβ therapies to date indicate that this peptide plays a minor role in the pathogenesis of AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2023-09-22

    Blood-brain barrier pathology in cerebral small vessel disease

    ✓ Peer-reviewed Vascular contributions Neural regeneration research

    Key finding: Notably, studies on small vessel disease suggest that blood-brain barrier dysfunction is among the earliest mechanisms in small vessel disease and might contribute to the development of the hallmarks of small vessel disease. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2023-09-22

    The prevalence and risk factors study of cognitive impairment: Analysis of the elderly population of Han nationality in Hunan province, China

    ✓ Peer-reviewed Risk factors CNS Neuroscience & Therapeutics

    Key finding: The prevalence of cognitive impairment, MCI, and dementia among participants aged 60 years and older were 21.48% (95% CI, 19.90-23.10), 15.70% (95% CI, 14.30-17.10), and 5.77 (95% CI, 4.90-6.70), respectively. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2023-09-22

    Reduction of concurrent use of highly anticholinergic medications in an integrated healthcare system: 2018–2021

    ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

    Key finding: Being in the top 5% indicates that 95% of all other Medicare Advantage plans prescribed more Poly-ACH regimens than KPSC. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2023-09-22

    Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

    ✓ Peer-reviewed Lewy body dementia Signal transduction and targeted therapy

    Key finding: Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2023-09-21

    Prevention of Alzheimer's disease through diet: An exploratory review

    ✓ Peer-reviewed Prevention and risk Metabolism open

    Key finding: Mediterranean diet (MD) accurately lowers AD (Alzheimer's Disease) risk to 53% and 35% for people who follow it moderately. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2023-09-21

    Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer's disease, Parkinson's disease, and multiple sclerosis

    ✓ Peer-reviewed Genetics Journal of translational medicine

    Key finding: The gene regulatory network analysis identified several hub genes regulated in AD, PD, and MS, in which HSPB1 and HSPA1A were key molecules. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2023-09-21

    Functional characterization of Alzheimer's disease genetic variants in microglia

    ✓ Peer-reviewed TREM2 and immune genetics Nature genetics

    Key finding: However, whether and how these genome-wide association studies (GWAS) variants contribute to AD remain elusive. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2023-09-20

    Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View

    ✓ Peer-reviewed Disease mechanisms Cells

    Key finding: Numerous interrelated pathways lead to the progression of neurodegeneration. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2023-09-20

    Impact of a multidomain lifestyle intervention on white matter integrity: the SUPERBRAIN exploratory sub-study

    ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience

    Key finding: In the statistical analysis using two-way repeated measures ANOVA, any significant difference in longitudinal changes in the FA, MD, AD, and RD was not revealed. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2023-09-20

    A Live Video Dyadic Resiliency Intervention to Prevent Chronic Emotional Distress Early After Dementia Diagnoses: Protocol for a Dyadic Mixed Methods Study

    ✓ Peer-reviewed Treatments JMIR research protocols

    Key finding: We will use results from this study to develop the first live video telehealth dyadic resiliency intervention focused on the prevention of chronic emotional distress in couples shortly after ADRD diagnoses. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2023-09-20

    Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease

    ✓ Peer-reviewed Treatments Alzheimer's research & therapy

    Key finding: Additionally, our results indicate that AD subjects carrying APOE ε4 are more responsive to the neuroprotective effects of physical activity. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2023-09-19

    Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases

    ✓ Peer-reviewed Inflammation and the immune system Inflammation research : official journal of the European Histamine Research Society ... [et al.]

    Key finding: The aim of this review is to explore the role of NLRP3 activation-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2023-09-19

    Alzheimer's disease: From immunotherapy to immunoprevention

    ✓ Peer-reviewed Treatments Cell

    Key finding: Recent Aβ-immunotherapy trials have yielded the first clear evidence that removing aggregated Aβ from the brains of symptomatic patients can slow the progression of Alzheimer's disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2023-09-19

    The role of plasma neurofilament light chain and glial fibrillary acidic protein in subjective cognitive decline and mild cognitive impairment

    ✓ Peer-reviewed Biomarkers Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    Key finding: GFAP was lower in NB compared to prodromal AD (p = 0.003, d = 1.463) and AD-D (p = 0.002, d = 1.695). +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2023-09-18

    Glycogen Synthase Kinase-3β, NLRP3 Inflammasome, and Alzheimer's Disease

    ✓ Peer-reviewed Inflammation and the immune system Current medical science

    Key finding: Another research focus of AD in recent years is the inflammasome, a multiprotein complex acting as a regulator in immunological reactions to exogenous and endogenous danger signals, of which the Nod-like receptor (NLR) family, pyrin domain-containing 3 (NLRP3) inflammasome has been studied mostly in AD and proven to play a significant role in AD development by its activation and downstream effects such as caspase-1 maturation and interleukin (IL)-1β release. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2023-09-18

    Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway

    ✓ Peer-reviewed Drug development Neuropharmacology

    Key finding: In this study, we found that SIRT1 is closely related to expression of GLP-1R in hippocampus of 3xTg mice. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2023-09-18

    Care Ecosystem Collaborative Model and Health Care Costs in Medicare Beneficiaries With Dementia: A Secondary Analysis of a Randomized Clinical Trial

    ✓ Peer-reviewed Health systems and care delivery JAMA internal medicine

    Key finding: To determine the effect of participation in collaborative dementia care on total Medicare reimbursement costs compared with usual care. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2023-09-15

    Dementia and Hearing Aid Use and Cessation: A National Study

    ✓ Peer-reviewed Risk factors American journal of audiology

    Key finding: Of 1,310 older adults who reported hearing loss (25% 80-84 years, 51% women, 74% White), 22% with dementia and 57% baseline hearing aid use. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2023-09-15

    Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation

    ✓ Peer-reviewed Genetics Nature communications

    Key finding: These findings highlight a context-dependent molecular disruption in C9-ALS and C9-FTD, indicating unique effects across cell types, brain regions, and diseases.

    Full summary, score breakdown and related studies → Original source

  22. 2023-09-15

    Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis

    ✓ Peer-reviewed Genetics Cancer research

    Key finding: APOE germline variants impact melanoma progression through disparate mechanisms, such as the protein synthesis-promoting function of the APOE2 variant, indicating that germline genetic variants are causal contributors to metastatic outcomes. +1 more finding

    Full summary, score breakdown and related studies → Original source

  23. 2023-09-15

    Early Alzheimer's Disease Screening Approach Using Plasma Biomarkers

    ✓ Peer-reviewed Biomarkers International journal of molecular sciences

    Key finding: Plasma p-Tau181 and GFAP showed the highest levels in AD dementia, and significant correlations with clinical AD characteristics; meanwhile, NfL showed the highest levels in FTD, but no significant correlations with AD.

    Full summary, score breakdown and related studies → Original source

  24. 2023-09-15

    Medicare Advantage Enrollment and Disenrollment Among Persons With Alzheimer Disease and Related Dementias

    ✓ Peer-reviewed Health systems and care delivery JAMA Health Forum

    Key finding: In this cross-sectional study of the Medicare population with acute and postacute care use, beneficiaries with ADRD had increasing enrollment in the Medicare Advantage program, proportional to the growth in overall enrollment, but their disenrollment from Medicare Advantage in the following year remained higher compared with beneficiaries without ADRD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2023-09-15

    Medicare Advantage Enrollment and Disenrollment Among Persons With Alzheimer Disease and Related Dementias

    ✓ Peer-reviewed Health systems and care delivery JAMA Health Forum

    Key finding: The 32 796 872 Medicare beneficiaries in the cohort had a mean (SD) age of 74.0 (12.5) years and included 18 228 513 females (55.6%). +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →