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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 16,501–16,525 of 27,380 studies, newest first · page 661 of 1096.

December 2015 25

  1. 2015-12-11

    Alzheimer Disease and Behavioral Variant Frontotemporal Dementia: Automatic Classification Based on Cortical Atrophy for Single-Subject Diagnosis

    ✓ Peer-reviewed Digital health tools Radiology

    Key finding: The SVM can be used in single-subject discrimination and can help the clinician arrive at a diagnosis. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2015-12-11

    Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease

    ✓ Peer-reviewed Biomarkers The American journal of pathology

    Key finding: Amyloid (senile) plaques, one of the two pathologic hallmarks of Alzheimer disease (AD), are associated with dystrophic neurites and glial responses, both astrocytic and microglial. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2015-12-10

    Development of interventions for the secondary prevention of Alzheimer's dementia: the European Prevention of Alzheimer's Dementia (EPAD) project

    ✓ Peer-reviewed Prevention and risk The lancet. Psychiatry

    Key finding: EPAD will help with testing of different agents in this pre-dementia population through four components: improvement of access to existing cohorts and registries, development of the EPAD Registry of approximately 24,000 people who might be at increased risk of developing Alzheimer's dementia, establishment of the EPAD Longitudinal Cohort Study of 6000 people at any one time, and establishment of an adaptive, proof-of-concept trial including 1500 participants at any given time.

    Full summary, score breakdown and related studies → Original source

  4. 2015-12-10

    Economic hardship and biological weathering: The epigenetics of aging in a U.S. sample of black women

    ✓ Peer-reviewed Prevention and risk Social science & medicine (1982)

    Key finding: These findings support the view that chronic financial pressures associated with low income exert a weathering effect that results in premature aging. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2015-12-09

    Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

    Key finding: BACE1 is the primary enzyme in Aβ generation. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2015-12-08

    Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies

    ✓ Peer-reviewed Tau biomarkers Brain : a journal of neurology

    Key finding: In vitro, extracellular α-synuclein is partially associated with exosomal vesicles. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2015-12-07

    Androgen Deprivation Therapy and Future Alzheimer's Disease Risk

    ✓ Peer-reviewed Digital health tools Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    Key finding: Our results support an association between the use of ADT in the treatment of prostate cancer and an increased risk of Alzheimer's disease in a general population cohort. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2015-12-07

    Does targeted cognitive training reduce educational disparities in cognitive function among cognitively normal older adults?

    ✓ Peer-reviewed Prevention trials International journal of geriatric psychiatry

    Key finding: Older adults with less than a secondary education are at elevated risk of dementia, including Alzheimer's disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2015-12-07

    Relationship of regional brain β-amyloid to gait speed

    ✓ Peer-reviewed Genetics Neurology

    Key finding: More research is needed to elucidate the neural mechanisms underlying these regional associations, which may involve motor and sensorimotor circuits hitherto largely neglected in the pathophysiology of AD.

    Full summary, score breakdown and related studies → Original source

  10. 2015-12-04

    Tau and neurodegenerative disease: the story so far

    ✓ Peer-reviewed Lewy body dementia Nature reviews. Neurology

    Key finding: Almost 80 disease-causing exonic missense and intronic silent mutations in the tau gene have been found in familial cases of frontotemporal dementia but, to date, no such mutation has been found in AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2015-12-03

    Tau in physiology and pathology

    ✓ Peer-reviewed Disease mechanisms Nature reviews. Neuroscience

    Key finding: Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules and thus in promoting axonal outgrowth. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2015-12-02

    Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise

    ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage

    Key finding: Surprisingly, we found no evidence of a vascular change as has been previously reported. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2015-12-02

    Diagnostic marker signature for esophageal cancer from transcriptome analysis

    ✓ Peer-reviewed TREM2 and immune genetics Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

    Key finding: Diagnostic markers are needed for achieving a cure in esophageal cancer detecting and treating tumor cells earlier. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2015-12-02

    Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of aging

    Key finding: Although ameliorative effects of BACE1 inhibition on β-amyloidosis and synaptic proteins levels have been previously noted in AD mouse models, our results highlight the additional potential value of BACE1 modulation in therapeutic targeting of endocytic dysfunction and cholinergic neurodegeneration in Down syndrome and AD.

    Full summary, score breakdown and related studies → Original source

  15. 2015-12-01

    Sampling the conformational space of the catalytic subunit of human γ-secretase

    ✓ Peer-reviewed Risk genes beyond APOE eLife

    Key finding: Our previous cryo-EM structure of γ-secretase revealed considerable disorder in its catalytic subunit presenilin. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2015-12 month only

    Bilingualism, dementia, cognitive and neural reserve

    ✓ Peer-reviewed Risk factors Current opinion in neurology

    Key finding: We discuss the role of bilingualism as a source of cognitive reserve and we propose the putative neural mechanisms through which lifelong bilingualism leads to a neural reserve that delays the onset of dementia.

    Full summary, score breakdown and related studies → Original source

  17. 2015-12 month only

    Sleep, Cognition and Dementia

    ✓ Peer-reviewed Risk factors Current psychiatry reports

    Key finding: Chronic and pervasive sleep complaints and disturbances are frequently associated with excessive daytime sleepiness and may result in impaired cognition, diminished intellect, poor memory, confusion, and psychomotor retardation all of which may be misinterpreted as dementia.

    Full summary, score breakdown and related studies → Original source

  18. 2015-12-01

    Novel GLP-1 (Glucagon-Like Peptide-1) Analogues and Insulin in the Treatment for Alzheimer's Disease and Other Neurodegenerative Diseases

    ✓ Peer-reviewed Drug development CNS drugs

    Key finding: Since insulin and insulin receptors are known to be present in the brain, the downstream signalling as well as the effect of hyperinsulinemia have been extensively studied in both AD and Parkinson's disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2015-12-01

    Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning

    ✓ Peer-reviewed Genetics Aging

    Key finding: Further, it is associated with a decline in global cognitive functioning (β=-0.500, p=0.009), episodic memory (β=-0.411, p=0.009) and working memory (β=-0.405, p=0.011) among individuals with AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2015-12-01

    Prion Diseases

    ✓ Peer-reviewed Disease mechanisms Continuum (Minneapolis, Minn.)

    Key finding: This article presents an update on the clinical aspects of human prion disease, including the wide spectrum of their presentations. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2015-12-01

    Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay

    ✓ Peer-reviewed Tau biomarkers Molecular neurodegeneration

    Key finding: Currently there are no effective treatments for many neurodegenerative diseases. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2015-12-01

    Blood-Brain Barrier Disruption Is an Early Event That May Persist for Many Years After Traumatic Brain Injury in Humans

    ✓ Peer-reviewed Risk factors Journal of neuropathology and experimental neurology

    Key finding: Autopsy cases of single moderate or severe TBI from the Glasgow TBI Archive (n = 70) were selected to include a range from acute (10 hours-13 days) to long-term (1-47 years) survival, together with age-matched uninjured controls (n = 21). +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2015-12-01

    Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases

    ✓ Peer-reviewed Risk factors Scandinavian journal of medicine & science in sports

    Key finding: This review provides the reader with the up-to-date evidence-based basis for prescribing exercise as medicine in the treatment of 26 different diseases: psychiatric diseases (depression, anxiety, stress, schizophrenia); neurological diseases (dementia, Parkinson's disease, multiple sclerosis); metabolic diseases (obesity, hyperlipidemia, metabolic syndrome, polycystic ovarian syndrome, type 2 diabetes, type 1 diabetes); cardiovascular diseases (hypertension, coronary heart disease, heart failure, cerebral apoplexy, and claudication intermittent); pulmonary diseases (chronic obstructive pulmonary disease, asthma, cystic fibrosis); musculo-skeletal disorders (osteoarthritis, osteoporosis, back pain, rheumatoid arthritis); and cancer. +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2015-12-01

    Effect of Delirium and Other Major Complications on Outcomes After Elective Surgery in Older Adults

    ✓ Peer-reviewed How common it is JAMA surgery

    Key finding: Major postoperative complications and delirium are separately associated with adverse events and demonstrate a combined effect. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2015-12-01

    Multisensory Stimulation as an Intervention Strategy for Elderly Patients With Severe Dementia: A Pilot Randomized Controlled Trial

    ✓ Peer-reviewed Treatments American journal of Alzheimer's disease and other dementias

    Key finding: Patients in the MSSE group demonstrated a significant improvement in the Neuropsychiatric Inventory and Bedford Alzheimer Nursing Severity Scale scores compared with the activity group. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →