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43/100

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Treatments

Topic: Amyloid, tau and blood-test diagnosis

Significantly increased levels of oxidized nucleic acids, proteins, and lipids have been described in the brains of subjects with Alzheimer disease (AD) and mild cognitive impairment (MCI) as well as young adults with Down syndrome, compared to age-matched controls. Therefore, it is speculated that oxidative stress (OS) and consequent cellular damage occur at an early-stage in the pathological cascade of AD. Until now, several antioxidants, mitochondrial protective agents, anti-inflammatory agents and metal chelators have been tested as possible OS-targeting therapeutics for AD. Although some of these agents have shown significant neuroprotective effects in cellular and animal models of AD, their efficacies in AD clinical trials have not been fully established. When limited efficacies of exogenous antioxidants in previous trials are taken into account, early-stage interventions aimed to activate endogenous antioxidants may be promising as OS-targeting therapeutic strategies for AD. A recent randomized controlled trial of dietary intervention for amnestic MCI is a good example of such an approach, where an OS-marker in cerebrospinal fluid is decreased and cognitive function is successfully improved by a diet with low-saturated fat and low-glycemic index. Indeed, transcriptional activators of endogenous antioxidants should be researched and tested in future clinical trials for AD.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Nunomura, A. (2013). [Oxidative stress hypothesis for Alzheimer's disease and its potential therapeutic implications]. Rinsho shinkeigaku = Clinical neurology. https://doi.org/10.5692/clinicalneurol.53.1043

Vancouver

Nunomura A. [Oxidative stress hypothesis for Alzheimer's disease and its potential therapeutic implications]. Rinsho shinkeigaku = Clinical neurology. 2013. doi:10.5692/clinicalneurol.53.1043. PMID: 24291874.

BibTeX

@article{nunomura2013-24291874,
  author  = {Nunomura, A.},
  title   = {{[Oxidative stress hypothesis for Alzheimer's disease and its potential therapeutic implications]}},
  journal = {Rinsho shinkeigaku = Clinical neurology},
  year    = {2013},
  doi     = {10.5692/clinicalneurol.53.1043},
  pmid    = {24291874},
  url     = {https://doi.org/10.5692/clinicalneurol.53.1043}
}

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Key findings

Significantly increased levels of oxidized nucleic acids, proteins, and lipids have been described in the brains of subjects with Alzheimer disease (AD) and mild cognitive impairment (MCI) as well as young adults with Down syndrome, compared to age-matched controls.
Although some of these agents have shown significant neuroprotective effects in cellular and animal models of AD, their efficacies in AD clinical trials have not been fully established.

Why it matters

This review notes that oxidized molecules are found in the brains of people with Alzheimer disease and mild cognitive impairment, suggesting oxidative stress occurs early. Several antioxidants and related agents have shown protective effects in cells and animals, but their effectiveness in human trials has not been established.

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Study details

Study designrandomized controlled trial
Evidence strengthHigh

How this study scored 43/100

Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for sample size, effect reported and studied in people because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Rinsho shinkeigaku = Clinical neurology)
Journal's citation record	0 / 4	Rinsho Shinkeigaku: journal h-index 19 (OpenAlex, 2026-10-29)
Study design	11 / 12	A randomised controlled trial
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2013 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	1 / 2	Randomised (as stated in the record)
Times cited	2 / 7	Cited 13 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.9 citations a year over 15 year(s) since 2013
Impact for its field and year	1 / 6	Cited 0.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Akihiko Nunomura: h-index 70 (OpenAlex, whole career)
Institution's track record	0 / 3	University of Yamanashi: institution h-index 335 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 24291874)
Free to read	0 / 2	Behind a paywall — scores zero
Total	43 / 100	—

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