Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,126–19,150 of 27,380 studies, newest first · page 766 of 1096.
November 2012 2
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2012-11-01
Safety and tolerability of the γ-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease
74/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: Avagacestat dosed at 25 and 50 mg daily was relatively well tolerated and had low discontinuation rates. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-11-01
Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders
59/100 ✓ Peer-reviewed Biomarkers Archives of neurology
Key finding: Ascertainment of the -synuclein level in CSF somewhat improves the differential diagnosis of AD vs DLB and PDD when combined with established AD biomarkers. +2 more findings
Full summary, score breakdown and related studies → Original source
October 2012 23
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2012-10-30
Excitotoxicity: bridge to various triggers in neurodegenerative disorders
36/100 ✓ Peer-reviewed Risk factors European journal of pharmacology
Key finding: Such an aberration, serves as a common pool or bridge between abnormal triggers and deleterious signaling processes with which central neurons cannot cope up, leading to death. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-30
Statistical analysis of longitudinal neuroimage data with Linear Mixed Effects models
52/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage
Key finding: Our results suggest that the LME approach offers superior statistical power in detecting longitudinal group differences.
Full summary, score breakdown and related studies → Original source
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2012-10-30
Influence of hospice on nursing home residents with advanced dementia who received Medicare-skilled nursing facility care near the end of life
55/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: Residents dying with advanced dementia who received SNF care in the last 90 days of life had fewer aggressive treatments and lower odds of hospital death if they also received hospice care at any point during that time. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-30
Gait and cognition: a complementary approach to understanding brain function and the risk of falling
36/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society
Key finding: Quantifiable alterations in gait in older adults are associated with falls, dementia, and disability. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-10-30
Psychosocial factors that shape patient and carer experiences of dementia diagnosis and treatment: a systematic review of qualitative studies
71/100 ✓ Peer-reviewed Caregiving PLoS medicine
Key finding: There is an extensive body of qualitative literature on the experiences of community-dwelling individuals with dementia on receiving and adapting to a diagnosis of dementia.
Full summary, score breakdown and related studies → Original source
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2012-10-29
Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study
57/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy
Key finding: Mean age of completers (n = 30) was 73.5 years and mean Mini-Mental Status Examination (MMSE) score was 22.5. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-27
Mild cognitive impairment in a community sample: the Sydney Memory and Ageing Study
58/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Incidence rates for MCI are higher than previously reported, particularly in men and for single-domain MCI; rates for amnestic and nonamnestic MCI were comparable. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-26
The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease
36/100 ✓ Peer-reviewed Drug development Neuroscience
Key finding: The results demonstrate that D-Ala(2)GIP has neuroprotective properties on key markers found in Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2012-10-26
Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies
47/100 ✓ Peer-reviewed Tau biomarkers The Journal of biological chemistry
Key finding: These diseases may occur by sporadic mechanisms in which genetic variants represent risk factors for disease, as is the case in Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-25
Diabetes in Older Adults: A Consensus Report
81/100 ✓ Peer-reviewed Brain scans and imaging Journal of the American Geriatrics Society
Key finding: More than 25% of the U.S. population aged ≥ 65 years has diabetes mellitus (hereafter referred to as diabetes),1 and the aging of the overall population is a significant driver of the diabetes epidemic. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-25
STAR: ultrafast universal RNA-seq aligner
56/100 ✓ Peer-reviewed Laboratory science Bioinformatics
STAR outperforms other aligners by a factor of >50 in mapping speed, aligning to the human genome 550 million 2 × 76 bp paired-end reads per hour on a modest 12-core server, while at the same time improving alignment sensitivity and precision.
Full summary, score breakdown and related studies → Original source
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2012-10-24
Functional network connectivity in the behavioral variant of frontotemporal dementia
38/100 ✓ Peer-reviewed Brain scans and imaging Cortex; a journal devoted to the study of the nervous system and behavior
Key finding: A decreased dorsal salience network (DSN) connectivity, mainly involving the anterior cingulum, was observed in bvFTD versus controls and pAD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-24
Seven sirtuins for seven deadly diseases of aging
44/100 ✓ Peer-reviewed Caregiving Free radical biology & medicine
Key finding: Since sirtuins are crucial to pathways that counter the decline in health that accompanies aging, pharmacological agents that boost sirtuin activity have clinical potential in treatment of diabetes, cardiovascular disease, dementia, osteoporosis, arthritis, and other conditions. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-24
A higher adherence to a Mediterranean-style diet is inversely associated with the development of frailty in community-dwelling elderly men and women
60/100 ✓ Peer-reviewed Prevention and risk The Journal of nutrition
Key finding: Adherence to a Mediterranean-style diet is associated with a lower risk for mortality, cognitive decline, and dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-24
Hormone therapy and Alzheimer disease dementia: new findings from the Cache County Study
68/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Association of HT use and risk of AD may depend on timing of use. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-24
Effects of APOE on brain white matter microstructure in healthy adults
48/100 ✓ Peer-reviewed Genetics Neurology
Key finding: APOE affects microstructural properties of the brain WM from early adulthood, but the specific allelic effects do not directly reflect the associated risk of developing Alzheimer disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-23
Cerebral blood flow in Alzheimer's disease
55/100 ✓ Peer-reviewed Hippocampus size on brain scans Vascular health and risk management
Key finding: These results indicate an association between brain hypoperfusion and the dementia of AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-23
The experience of providing end-of-life care to a relative with advanced dementia: an integrative literature review
36/100 ✓ Peer-reviewed End-of-life care Palliative & supportive care
Key finding: This article presents what is known and highlights the gaps in the literature relevant to the experiences of family caregivers of persons with dementia at the end of life. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-19
Longitudinal relationships between subjective fatigue, cognitive function, and everyday functioning in old age
69/100 ✓ Peer-reviewed Prevention trials International psychogeriatrics
Key finding: Future interventions should address subjective fatigue when managing cognitive and functional abilities in community-dwelling older adults. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-16
Physical activity, brain plasticity, and Alzheimer's disease
50/100 ✓ Peer-reviewed Prevention trials Archives of medical research
Key finding: The epidemiological literature provides compelling evidence that greater amounts of physical activity are associated with a reduced risk of dementia in late life. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-15
Cognitive reserve in ageing and Alzheimer's disease
62/100 ✓ Peer-reviewed Risk factors The Lancet Neurology
Key finding: The concept of cognitive reserve provides an explanation for differences between individuals in susceptibility to age-related brain changes or pathology related to Alzheimer's disease, whereby some people can tolerate more of these changes than others and maintain function. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-15
Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults
65/100 ✓ Peer-reviewed Brain tissue and pathology Diabetes care
Key finding: This longitudinal study examined whether insulin resistance among late middle-aged, cognitively healthy individuals was associated with 1) less gray matter in Alzheimer disease-sensitive brain regions and 2) worse cognitive performance. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-10-15
Mindfulness-based stress reduction for family caregivers: a randomized controlled trial
58/100 ✓ Peer-reviewed Disparities The Gerontologist
Key finding: MBSR was more effective at improving overall mental health, reducing stress, and decreasing depression than CCES. +1 more finding
Full summary, score breakdown and related studies → Original source
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