Home › Research › Brain tissue and pathology
Sleep quality and preclinical Alzheimer disease
Ju YE, McLeland JS, Toedebusch CD, Xiong C, Fagan AM, Duntley SP, Morris JC, Holtzman DM.. JAMA neurology, 2013-05-01
Topic: Amyloid, tau and blood-test diagnosis
Importance Sleep and circadian problems are very common in Alzheimer disease (AD). Recent animal studies suggest a bidirectional relationship between sleep and β-amyloid (Aβ), a key molecule involved in AD pathogenesis. Objective To test whether Aβ deposition in preclinical AD, prior to the appearance of cognitive impairment, is associated with changes in quality or quantity of sleep.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ju, Y. E., McLeland, J. S., Toedebusch, C. D., Xiong, C., Fagan, A. M., Duntley, S. P., et al. (2013). Sleep quality and preclinical Alzheimer disease. JAMA neurology. https://doi.org/10.1001/jamaneurol.2013.2334
Vancouver
Ju YE, McLeland JS, Toedebusch CD, Xiong C, Fagan AM, Duntley SP, et al. Sleep quality and preclinical Alzheimer disease. JAMA neurology. 2013. doi:10.1001/jamaneurol.2013.2334. PMID: 23479184.
BibTeX
@article{ju2013-23479184,
author = {Ju, Y. E. and McLeland, J. S. and Toedebusch, C. D. and Xiong, C. and Fagan, A. M. and Duntley, S. P. and Morris, J. C. and Holtzman, D. M.},
title = {{Sleep quality and preclinical Alzheimer disease}},
journal = {JAMA neurology},
year = {2013},
doi = {10.1001/jamaneurol.2013.2334},
pmid = {23479184},
url = {https://doi.org/10.1001/jamaneurol.2013.2334}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Recent animal studies suggest a bidirectional relationship between sleep and β-amyloid (Aβ), a key molecule involved in AD pathogenesis.
- Objective To test whether Aβ deposition in preclinical AD, prior to the appearance of cognitive impairment, is associated with changes in quality or quantity of sleep.
- Design Cross-sectional study conducted from October 2010 to June 2012.
- Setting General community volunteers at the Washington University Knight Alzheimer's Disease Research Center.
Why it matters
Sleep and circadian problems are "very common in Alzheimer disease," and the authors note that "recent animal studies suggest a bidirectional relationship between sleep and β-amyloid." This cross-sectional study of community volunteers at the Washington University Knight Alzheimer's Disease Research Center (October 2010 to June 2012) asked whether amyloid build-up in people who do not yet have memory or thinking problems goes along with changes in how well or how long they sleep. Our stored summary ends before the results, so check the original paper for what it found; a single snapshot like this can show an association but not which came first, and it tests no treatment.
Study details
- Study designcross-sectional
- Participants145
- Effect size22.5%; 80.4%; 83.7%
- Evidence strengthModerate
How this study scored 67/100
Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA neurology) |
| Journal's citation record | 2 / 4 | JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 145 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 742 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 49.5 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 5 / 6 | Cited 27.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 36 other studies in this library |
| Still being cited | 3 / 4 | Cited 176 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author David M. Holtzman: h-index 206 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23479184) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 67 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1001/jamaneurol.2013.2334
- PubMed: 23479184
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
36 studies in the alzhub library list this one in their references. Showing the 8 highest-scoring.
Related studies in Brain tissue and pathology
Also tagged “sleep-fragmentation-and-ad-risk”
4 studies in the library carry the topic tag “sleep-fragmentation-and-ad-risk”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 4 tagged studies.