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Recurrent seizures, progressive cognitive decline, Parkinsonism and a calcified brain: is it Fahr's disease?
Osama Shukir Muhammed Amin. BMJ Case Reports, 2013-05-09
Topic: Brain proteins, microglia and lab models
A 34-year-old man developed three generalised seizures over a period of 2 weeks. He had generalised rigidity and mild bilateral symmetrical resting tremor. His deep tendon reflexes were normal with downward planter reflexes. His elder brother noticed that the patient had a progressive cognitive decline over the past few years. He resides in a village and works in a grocery store. His blood tests, including serum calcium, phosphate, alkaline phosphatase and parathyroid hormone, were within their normal …
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Amin, O. S. M. (2013). Recurrent seizures, progressive cognitive decline, Parkinsonism and a calcified brain: is it Fahr's disease? BMJ Case Reports. https://doi.org/10.1136/bcr-2013-009853
Vancouver
Amin OSM. Recurrent seizures, progressive cognitive decline, Parkinsonism and a calcified brain: is it Fahr's disease? BMJ Case Reports. 2013. doi:10.1136/bcr-2013-009853. PMID: 23667227.
BibTeX
@article{amin2013-23667227,
author = {Amin, Osama Shukir Muhammed},
title = {{Recurrent seizures, progressive cognitive decline, Parkinsonism and a calcified brain: is it Fahr's disease?}},
journal = {BMJ Case Reports},
year = {2013},
doi = {10.1136/bcr-2013-009853},
pmid = {23667227},
url = {https://doi.org/10.1136/bcr-2013-009853}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- He had generalised rigidity and mild bilateral symmetrical resting tremor.
- His deep tendon reflexes were normal with downward planter reflexes.
- His elder brother noticed that the patient had a progressive cognitive decline over the past few years.
- He resides in a village and works in a grocery store.
- His blood tests, including serum calcium, phosphate, alkaline phosphatase and parathyroid hormone, were within their normal …
Why it matters
This case report describes a 34-year-old man with recurrent seizures, progressive cognitive decline, parkinsonism and a calcified brain, raising the question of Fahr's disease. It is a single case and does not provide evidence about treating, curing or preventing Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 27/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on institution's track record, so that was left out: it earned 26 of the 97 points we could judge it on, which is 27 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (BMJ Case Reports) |
| Journal's citation record | 0 / 4 | BMJ Case Reports: journal h-index 56 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.1 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 1 / 6 | Cited 0.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Osama Shukir Muhammed Amin: h-index 7 (OpenAlex, whole career) |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23667227) |
| Free to read | 2 / 2 | Free to read |
| Points | 26 / 97 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 26 of the 97 points we could judge it on is 27 out of 100. |
| Total | 27 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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