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Inflammatory process in Alzheimer's Disease
Meraz-Ríos MA, Toral-Rios D, Franco-Bocanegra D, Villeda-Hernández J, Campos-Peña V.. Frontiers in integrative neuroscience, 2013-08-13
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer Disease (AD) is a neurodegenerative disorder and the most common form of dementia. Histopathologically is characterized by the presence of two major hallmarks, the intracellular neurofibrillary tangles (NFTs) and extracellular neuritic plaques (NPs) surrounded by activated astrocytes and microglia. NFTs consist of paired helical filaments of truncated tau protein that is abnormally hyperphosphorylated.
Key findings
- Histopathologically is characterized by the presence of two major hallmarks, the intracellular neurofibrillary tangles (NFTs) and extracellular neuritic plaques (NPs) surrounded by activated astrocytes and microglia.
- NFTs consist of paired helical filaments of truncated tau protein that is abnormally hyperphosphorylated.
- The main component in the NP is the amyloid-β peptide (Aβ), a small fragment of 40-42 amino acids with a molecular weight of 4 kD.
- It has been proposed that the amyloid aggregates and microglia activation are able to favor the neurodegenerative process observed in AD patients.
Why it matters
This review describes the hallmark Alzheimer's pathology of neurofibrillary tangles and neuritic plaques surrounded by activated astrocytes and microglia, and notes that the main plaque component is amyloid-beta peptide. It reports no treatment, cure or prevention finding.
Study details
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in integrative neuroscience) |
| Journal's citation record | 1 / 4 | Frontiers in Integrative Neuroscience: journal h-index 104 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 427 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 28.5 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 4 / 6 | Cited 17.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 9 other studies in this library |
| Still being cited | 3 / 4 | Cited 89 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Victoria Campos‐Peña: h-index 17 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Universidad Nacional Autónoma de México: institution h-index 668 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23964211) |
| Free to read | 2 / 2 | Free to read |
| Total | 45 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3389/fnint.2013.00059
- PubMed: 23964211
- Original source →
- Free full text: Frontiers in Integrative Neuroscience →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Meraz-Ríos, M. A., Toral-Rios, D., Franco-Bocanegra, D., Villeda-Hernández, J., & Campos-Peña, V. (2013). Inflammatory process in Alzheimer's Disease. Frontiers in integrative neuroscience. https://doi.org/10.3389/fnint.2013.00059
Vancouver
Meraz-Ríos MA, Toral-Rios D, Franco-Bocanegra D, Villeda-Hernández J, Campos-Peña V. Inflammatory process in Alzheimer's Disease. Frontiers in integrative neuroscience. 2013. doi:10.3389/fnint.2013.00059. PMID: 23964211.
BibTeX
@article{merazrios2013-23964211,
author = {Meraz-Ríos, M. A. and Toral-Rios, D. and Franco-Bocanegra, D. and Villeda-Hernández, J. and Campos-Peña, V.},
title = {{Inflammatory process in Alzheimer's Disease}},
journal = {Frontiers in integrative neuroscience},
year = {2013},
doi = {10.3389/fnint.2013.00059},
pmid = {23964211},
url = {https://doi.org/10.3389/fnint.2013.00059}
}
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