Home › Research › Long-term cohort studies
Brain imaging and cognitive predictors of stroke and Alzheimer disease in the Framingham Heart Study
Weinstein G, Beiser AS, Decarli C, Au R, Wolf PA, Seshadri S.. Stroke, 2013-08-06
Topic: Amyloid, tau and blood-test diagnosis
Background and purpose Exposure to vascular risk factors has a gradual deleterious effect on brain MRI and cognitive measures. We explored whether a pattern of these measures exists that predicts stroke and Alzheimer disease (AD) risk. Methods A cognitive battery was administered to 1679 dementia and stroke-free Framingham offspring (age, >55 years; mean, 65.7±7.0) between 1999 and 2004; participants were also free of other neurological conditions that could affect cognition and >90% also had brain MRI examination.
Key findings
- We explored whether a pattern of these measures exists that predicts stroke and Alzheimer disease (AD) risk.
- Methods A cognitive battery was administered to 1679 dementia and stroke-free Framingham offspring (age, >55 years; mean, 65.7±7.0) between 1999 and 2004; participants were also free of other neurological conditions that could affect cognition and >90% also had brain MRI examination.
- We related cognitive and MRI measures to risks of incident stroke and AD ≤10 years of follow-up.
- As a secondary analysis, we explored these associations in The Framingham Heart Study original cohort (mean age, 67.5±7.3 and 84.8±3.3 years at the cognitive assessment and MRI examination, respectively).
Why it matters
This study explored whether patterns of brain MRI findings and cognitive test results can predict future stroke and Alzheimer's disease in people who were initially free of both. Such prediction could help identify high-risk individuals, but it does not offer a treatment or cure.
Study details
- Participants55
- Evidence strengthModerate
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Stroke) |
| Journal's citation record | 3 / 4 | Stroke: journal h-index 455 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 55 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 56 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.7 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 3 / 6 | Cited 4.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 1 / 4 | Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Sudha S. Seshadri: h-index 148 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Boston University: institution h-index 1,456 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23920020) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Weinstein, G., Beiser, A. S., Decarli, C., Au, R., Wolf, P. A., & Seshadri, S. (2013). Brain imaging and cognitive predictors of stroke and Alzheimer disease in the Framingham Heart Study. Stroke. https://doi.org/10.1161/strokeaha.113.000947
Vancouver
Weinstein G, Beiser AS, Decarli C, Au R, Wolf PA, Seshadri S. Brain imaging and cognitive predictors of stroke and Alzheimer disease in the Framingham Heart Study. Stroke. 2013. doi:10.1161/strokeaha.113.000947. PMID: 23920020.
BibTeX
@article{weinstein2013-23920020,
author = {Weinstein, G. and Beiser, A. S. and Decarli, C. and Au, R. and Wolf, P. A. and Seshadri, S.},
title = {{Brain imaging and cognitive predictors of stroke and Alzheimer disease in the Framingham Heart Study}},
journal = {Stroke},
year = {2013},
doi = {10.1161/strokeaha.113.000947},
pmid = {23920020},
url = {https://doi.org/10.1161/strokeaha.113.000947}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 19.
Later studies that cite this one
3 studies in the alzhub library list this one in their references.
Related studies in Long-term cohort studies
Also tagged “classification”
835 studies in the library carry the topic tag “classification”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 835 tagged studies.