Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 17,626–17,650 of 27,380 studies, newest first · page 706 of 1096.
September 2014 25
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2014-09-16
Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia
48/100 ✓ Peer-reviewed Inflammation and the immune system Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Alzheimer's disease (AD) and Parkinson's disease (PD) are the two common neurodegenerative diseases characterized by progressive neuronal dysfunction in the presence of pathological microglial activation. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-09-16
Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis
62/100 ✓ Peer-reviewed Genetics PLoS medicine
Key finding: Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking cholesterol and AD pathology are still not well understood and contradictory results have been reported. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-09-13
[Hearing impairment and dementia]
38/100 ✓ Peer-reviewed Risk factors Zeitschrift fur Gerontologie und Geriatrie
Key finding: The prevalence of dementia and hearing problems increases in aging societies. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-09-13
Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis
80/100 ✓ Peer-reviewed How common it is Acta psychiatrica Scandinavica
Key finding: Older people with SMC but no objective complaints are twice as likely to develop dementia as individuals without SMC. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-09-12
Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients
40/100 ✓ Peer-reviewed Treatments Nature communications
Key finding: Our results suggest that aside from filamentous aggregates, TDP-43 oligomers may play a role in TDP-43 pathogenesis.
Full summary, score breakdown and related studies → Original source
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2014-09-12
Tailored lighting intervention improves measures of sleep, depression, and agitation in persons with Alzheimer's disease and related dementia living in long-term care facilities
40/100 ✓ Peer-reviewed Clinical safety Clinical interventions in aging
Key finding: A lighting intervention, tailored to increase daytime circadian stimulation, can be used to increase sleep quality and improve behavior in patients with ADRD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-09-12
The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies
36/100 ✓ Peer-reviewed Clinical safety Brain pathology (Zurich, Switzerland)
Key finding: These findings can contribute to a large variety of less well-explained PD and DLB symptoms (eg, gait and postural instability, impaired balance and postural reflexes, falls, ingestive and oculomotor dysfunctions) and point to the occurrence of disturbances of intra-axonal transport processes and transneuronal spread of the underlying pathological processes of PD and DLB along anatomical pathways.
Full summary, score breakdown and related studies → Original source
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2014-09-12
Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo
41/100 ✓ Peer-reviewed Genetics The Journal of biological chemistry
Key finding: RXR agonists induced no beneficial effects in the E4FAD-HP in a prevention protocol (5-6 months) and actually increased soluble Aβ levels in E3FAD-CX and E4FAD-CX with the short-term protocol, possibly the result of systemic hepatomegaly. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-09-11
The Mini-Addenbrooke's Cognitive Examination: a new assessment tool for dementia
54/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia and geriatric cognitive disorders
Key finding: We developed and validated the Mini-Addenbrooke's Cognitive Examination (M-ACE) in dementia patients. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-09-10
APOE ε4: the most prevalent yet understudied risk factor for Alzheimer's disease
41/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Although this approach still remains valid, none of the compounds tested to date have produced clinically meaningful results.
Full summary, score breakdown and related studies → Original source
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2014-09-10
Assessment of blood-brain barrier disruption using dynamic contrast-enhanced MRI. A systematic review
60/100 ✓ Peer-reviewed Vascular contributions NeuroImage. Clinical
Key finding: In conclusion, DCE-MRI is shown to provide valuable information in a large variety of applications, ranging from common applications, such as grading of primary brain tumors, to more recent applications, such as assessment of subtle BBB dysfunction in Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2014-09-10
Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study
68/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Plasma amyloid-β (Aβ) peptide levels have been examined as a low-cost accessible marker for risk of incident Alzheimer's disease (AD) and dementia, but results have varied between studies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-09-09
Cognitive impairment and memory dysfunction after a stroke diagnosis: a post-stroke memory assessment
40/100 ✓ Peer-reviewed Vascular contributions Neuropsychiatric disease and treatment
Key finding: Cognitive impairment and memory dysfunction following stroke diagnosis are common symptoms that significantly affect the survivors' quality of life. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-09-09
Benzodiazepine use and risk of Alzheimer's disease: case-control study
69/100 ✓ Peer-reviewed Getting a diagnosis BMJ (Clinical research ed.)
Key finding: Benzodiazepine use is associated with an increased risk of Alzheimer's disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-09-08
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method
69/100 ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America
Key finding: We identify common genetic variants associated with cognitive performance using a two-stage approach, which we call the proxy-phenotype method. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-09-08
A stereological study of the mediodorsal thalamic nucleus in Down syndrome
35/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neuroscience
Key finding: The total number of neurons and glial cells in the mediodorsal thalamic (MDT) nucleus of four aged females with Down syndrome (DS; mean age 69years) was estimated and compared to six age- and sex-matched controls. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-09-07
Aβ immunotherapy for Alzheimer's disease: effects on apoE and cerebral vasculopathy
40/100 ✓ Peer-reviewed Treatments Acta neuropathologica
Key finding: Aβ immunotherapy for Alzheimer's disease (AD) results in the removal of Aβ plaques and increased cerebral amyloid angiopathy (CAA). +4 more findings
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2014-09-06
Measuring end-of-life care and outcomes in residential care/assisted living and nursing homes
68/100 ✓ Peer-reviewed Health systems and care delivery Journal of pain and symptom management
Key finding: Prioritizing measures that distinguish the assessment of care from the assessment of dying, and secondarily that exhibit an acceptable factor structure, this study recommends two measures of care-the Family Perceptions of Physician-Family Caregiver Communication and the End of Life in Dementia (EOLD)-Satisfaction With Care-and two measures of outcomes-the EOLD-Symptom Management and the EOLD-Comfort Assessment in Dying. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-09-06
Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models
43/100 ✓ Peer-reviewed TREM2 and immune genetics Neurobiology of aging
Key finding: These subjects were grouped based on neurofibrillary pathology into 3 groups: Braak stages 0-II, Braak stages III-IV, and Braak stages V-VI. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-09-04
Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50-89 years: a cross-sectional study
48/100 ✓ Peer-reviewed Hippocampus size on brain scans The Lancet. Neurology
Key finding: As preclinical Alzheimer's disease becomes a target for therapeutic intervention, the overlap between imaging abnormalities associated with typical ageing and those associated with Alzheimer's disease needs to be recognised. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-09-04
Test accuracy of cognitive screening tests for diagnosis of dementia and multidomain cognitive impairment in stroke
61/100 ✓ Peer-reviewed Cognitive tests and assessment Stroke
Key finding: Guidelines recommend screening stroke-survivors for cognitive impairments. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-09-04
Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias
64/100 ✓ Peer-reviewed Lewy body dementia PLoS genetics
Key finding: GalNAc transferase 7 (GALNT7), ATP-Binding Cassette, Sub-Family G (WHITE), Member 1 (ABCG1), and an intergenic region on chromosome 9 were associated with NP score; and Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Beta Member 2 (KCNMB2) was strongly associated with HS. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-09-03
Poor sleep quality is associated with increased cortical atrophy in community-dwelling adults
50/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology
Key finding: We found that longitudinal measures of cortical atrophy were widely correlated with sleep quality. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-09-03
End of life care: The experiences of advance care planning amongst family caregivers of people with advanced dementia - A qualitative study
36/100 ✓ Peer-reviewed End-of-life care Dementia (London, England)
Key finding: Advance care planning can be facilitated with the family caregiver in the context of everyday practice within the nursing home environment for older people with dementia.
Full summary, score breakdown and related studies → Original source
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2014-09-03
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
58/100 ✓ Peer-reviewed Laboratory science Journal of Neuroscience
The major cell classes of the brain differ in their developmental processes, metabolism, signaling, and function.
Full summary, score breakdown and related studies → Original source
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