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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 23,826–23,850 of 27,380 studies, newest first · page 954 of 1096.

January 2005 15

  1. 2005-01-01

    S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production

    ✓ Peer-reviewed Risk genes beyond APOE Molecular and cellular neurosciences

    Key finding: It has already been shown that DNA methylation is involved in amyloid precursor protein (APP) processing and beta-amyloid (A beta) production through the regulation of Presenilin1 (PS1) expression and that exogenous S-adenosylmethionine (SAM) can silence the gene reducing A beta production. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2005-01-01

    Tau pathology in Alzheimer disease and other tauopathies

    ✓ Peer-reviewed Lewy body dementia Biochimica et biophysica acta

    Key finding: The abnormal hyperphosphorylation not only results in the loss of tau function of promoting assembly and stabilizing microtubules but also in a gain of a toxic function whereby the pathological tau sequesters normal tau, MAP1A/MAP1B and MAP2, and causes inhibition and disruption of microtubules. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2005-01-01

    Extracellular deposits of A beta produced in cultures of Alzheimer disease brain vascular smooth muscle cells

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neuropathology and experimental neurology

    Key finding: Cell culture models of vascular amyloidosis-beta revealed intracellular, but not extracellular deposition of Abeta. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2005-01-01

    Mutations causing neurodegenerative tauopathies

    ✓ Peer-reviewed Risk factors Biochimica et biophysica acta

    Key finding: Moreover, the H1 haplotype of Tau has been identified as a significant risk factor for progressive supranuclear palsy and corticobasal degeneration.

    Full summary, score breakdown and related studies → Original source

  5. 2005-01-01

    The neuropathogenesis of AIDS

    ✓ Peer-reviewed How common it is Nature reviews. Immunology

    Key finding: HIV-associated dementia (HAD) is an important complication of the central nervous system in patients who are infected with HIV-1. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2005-01-01

    Midlife cardiovascular risk factors and risk of dementia in late life

    ✓ Peer-reviewed How common it is Neurology

    Key finding: The presence of multiple cardiovascular risk factors at midlife substantially increases risk of late-life dementia in a dose dependent manner. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2005-01-01

    Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementia

    ✓ Peer-reviewed Caregiving Annals of neurology

    Key finding: Retrospective clinical assessment then showed that only 32 (30%) of 106 alpha-synuclein-positive cases were diagnosed with a neurodegenerative disorder. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2005-01-01

    Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD

    ✓ Peer-reviewed Caregiving Neurology

    Key finding: AN1792 + QS-21 elicited a positive antibody response to Abeta42 in more than half of this elderly study population. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2005-01-01

    Impact of age-related cerebral white matter changes on the transition to disability -- the LADIS study: rationale, design and methodology

    ✓ Peer-reviewed Caregiving Neuroepidemiology

    Key finding: Age-related white matter changes (ARWMC) on brain MRI have been associated with cognitive, motor, mood and urinary disturbances. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2005-01-01

    Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: Because NAA is considered a marker of neuronal integrity, reduced medial temporal and parietal lobe NAA could be an early indication of dementia-related pathology in elderly individuals.

    Full summary, score breakdown and related studies → Original source

  11. 2005-01-01

    EEG coherence reflects regional corpus callosum area in Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Journal of neurology, neurosurgery, and psychiatry

    Key finding: Region specific correlations between corpus callosum size and EEG coherence suggest that the decline in interhemispheric connectivity in Alzheimer's disease results from a specific loss of cortical association neurones projecting through the corpus callosum. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2005-01-01

    Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: Blood pressure and indicators of small-vessel disease in the brain may be associated with atrophy of structures affected by Alzheimer pathology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2005-01-01

    A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study

    ✓ Peer-reviewed Getting a diagnosis Archives of neurology

    Key finding: Dementia-associated weight loss begins before the onset of the clinical syndrome and accelerates by the time of diagnosis. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2005-01-01

    Genetic susceptibility testing versus family history-based risk assessment: Impact on perceived risk of Alzheimer disease

    ✓ Peer-reviewed Treatments Genetics in medicine : official journal of the American College of Medical Genetics

    Key finding: We examined how an Alzheimer disease (AD) family history assessment as compared to a risk assessment incorporating the absence of a disease-associated susceptibility allele affected risk perception among adult children with a family history of AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2005-01-01

    Cerebral glucose metabolism in patients with AD and different APOE genotypes

    ✓ Peer-reviewed Genetics Neurology

    Key finding: A generally similar pattern of cerebral hypometabolism was detected in APOE epsilon4-positive and -negative patients with Alzheimer disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

December 2004 10

  1. 2004-12-23

    Prognostic significance of delirium in frail older people

    ✓ Peer-reviewed Clinical safety Dementia and geriatric cognitive disorders

    Key finding: The prevalence of delirium at baseline was 24.9% (106/425). +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2004-12-23

    Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease

    ✓ Peer-reviewed Disease mechanisms Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Transgenic Tg(PG14) mice express a mutant prion protein containing 14 octapeptide repeats, whose human homologue is associated with an inherited prion dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2004-12-21

    GGA proteins mediate the recycling pathway of memapsin 2 (BACE)

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

    Key finding: Both memapsin 2 and APP are transported from the cell surface to endosomes where APP is cleaved by memapsin 2. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2004-12-17

    Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins

    ✓ Peer-reviewed Lewy body dementia The Journal of biological chemistry

    Key finding: Biochemical analysis revealed the formation of soluble oligomeric tau in the presence of the inhibitory compounds, suggesting that this may be the mechanism by which tau filament formation is inhibited.

    Full summary, score breakdown and related studies → Original source

  5. 2004-12-15

    Representation of patients with dementia in clinical trials of donepezil

    ✓ Peer-reviewed Digital health tools The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique

    Key finding: Fewer than half of the older adults dispensed donepezil in Ontario would have been eligible to participate in the RCTs that established the efficacy of this drug. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2004-12-10

    Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu

    ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of aging

    Key finding: We report here that an aged wild-type South American rodent, Octodon degu, expresses neuronal beta-amyloid precursor protein (beta-APP695) displaying both intracellular and extracellular deposits of amyloid-beta-peptide (Abeta), intracellular accumulations of tau-protein and ubiquitin, a strong astrocytic response and acetylcholinesterase (AChE)-rich pyramidal neurons. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2004-12-08

    Gait slowing as a predictor of incident dementia: 6-year longitudinal data from the Sydney Older Persons Study

    ✓ Peer-reviewed Digital health tools Journal of the neurological sciences

    Key finding: Those with cognitive impairment in combination with gait and motor slowing were the most likely to dement over the 6-year period (OR 5.6; 95% CI 2.5-12.6). +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2004-12-08

    Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

    ✓ Peer-reviewed Brain tissue and pathology Journal of neuroinflammation

    Key finding: Anti-Abeta immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2004-12-07

    Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

    ✓ Peer-reviewed Vascular contributions The Journal of biological chemistry

    Key finding: AD and Tg2576 mice brain sections incubated with curcumin revealed preferential labeling of amyloid plaques. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2004-12-07

    Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3

    ✓ Peer-reviewed Drug development Journal of cell science

    Key finding: We and others have shown that ER stress can induce intracellular lipid accumulation through the activation of the sterol responsive element binding proteins (SREBPs) and initiate programmed cell death by activation of caspases. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →