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58/100

✓ Peer-reviewed alzhub usefulness score 58 out of 100. How common it is

Topic: Risk, prevention and care in population studies

Results During 20 years, baseline hypertension was associated with an additional decline of 0.056 global z score points (95% CI, -0.100 to -0.012) and prehypertension was associated nonsignificantly with 0.040 more global z score points of decline (95% CI, -0.085 to 0.005) compared with normal BP. Having a JNC-8-specified indication for initiating antihypertensive treatment at baseline was associated with a greater 20-year decline (-0.044 [95% CI, -0.085 to -0.003] global z score points) than not having an indication. We observed effect modification by race for the continuous systolic BP analyses (P = .01), with each 20-mm Hg increment at baseline associated with an additional decline of 0.048 (95% CI, -0.074 to -0.022) points in global cognitive z score in whites but not in African Americans (decline, -0.020 [95% CI, -0.026 to 0.066] points). Systolic BP at the end of follow-up was not associated with the preceding 20 years of cognitive change in either group. Conclusions and relevance Midlife hypertension and elevated midlife but not late-life systolic BP was associated with more cognitive decline during the 20 years of the study.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Gottesman, R. F., Schneider, A. L., Albert, M., Alonso, A., Bandeen-Roche, K., Coker, L., et al. (2014). Midlife hypertension and 20-year cognitive change: the atherosclerosis risk in communities neurocognitive study. JAMA neurology. https://doi.org/10.1001/jamaneurol.2014.1646

Vancouver

Gottesman RF, Schneider AL, Albert M, Alonso A, Bandeen-Roche K, Coker L, et al. Midlife hypertension and 20-year cognitive change: the atherosclerosis risk in communities neurocognitive study. JAMA neurology. 2014. doi:10.1001/jamaneurol.2014.1646. PMID: 25090106.

BibTeX

@article{gottesman2014-25090106,
  author  = {Gottesman, R. F. and Schneider, A. L. and Albert, M. and Alonso, A. and Bandeen-Roche, K. and Coker, L. and Coresh, J. and Knopman, D. and others},
  title   = {{Midlife hypertension and 20-year cognitive change: the atherosclerosis risk in communities neurocognitive study}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2014.1646},
  pmid    = {25090106},
  url     = {https://doi.org/10.1001/jamaneurol.2014.1646}
}

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Key findings

Results During 20 years, baseline hypertension was associated with an additional decline of 0.056 global z score points (95% CI, -0.100 to -0.012) and prehypertension was associated nonsignificantly with 0.040 more global z score points of decline (95% CI, -0.085 to 0.005) compared with normal BP.
Having a JNC-8-specified indication for initiating antihypertensive treatment at baseline was associated with a greater 20-year decline (-0.044 [95% CI, -0.085 to -0.003] global z score points) than not having an indication.
We observed effect modification by race for the continuous systolic BP analyses (P = .01), with each 20-mm Hg increment at baseline associated with an additional decline of 0.048 (95% CI, -0.074 to -0.022) points in global cognitive z score in whites but not in African Americans (decline, -0.020 [95% CI, -0.026 to 0.066] points).
Systolic BP at the end of follow-up was not associated with the preceding 20 years of cognitive change in either group.
Conclusions and relevance Midlife hypertension and elevated midlife but not late-life systolic BP was associated with more cognitive decline during the 20 years of the study.

Why it matters

This study found that midlife hypertension and elevated midlife systolic blood pressure were associated with more cognitive decline over 20 years, while late-life systolic blood pressure was not. It identifies midlife blood pressure as a possible target for prevention research but does not test any treatment.

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Study details

Effect size58.0%
Evidence strengthModerate

How this study scored 58/100

Published in a leading specialty journal. Scored zero for study design, sample size, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2014 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	6 / 7	Cited 471 times (OpenAlex, 2026-10-10)
Citations per year	4 / 5	33.6 citations a year over 14 year(s) since 2014
Impact for its field and year	5 / 6	Cited 23.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	4 / 6	Cited by 34 other studies in this library
Still being cited	3 / 4	Cited 104 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Thomas H. Mosley: h-index 94 (OpenAlex, whole career)
Institution's track record	2 / 3	Johns Hopkins University: institution h-index 2,306 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 8 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 25090106)
Free to read	0 / 2	Behind a paywall — scores zero
Total	58 / 100	—

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