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Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage
Vos SJ, Verhey F, Frölich L, Kornhuber J, Wiltfang J, Maier W, Peters O, Rüther E et al.. Brain : a journal of neurology, 2015-02-17
Topic: Amyloid, tau and blood-test diagnosis
Their 3-year progression rate to Alzheimer's disease-type dementia was 50% compared to 21% for subjects without prodromal Alzheimer's disease. Their 3-year progression rate to Alzheimer's disease-type dementia was 61% compared to 22% for subjects without prodromal Alzheimer's disease. Our findings support the use of the proposed research criteria to identify Alzheimer's disease at the mild cognitive impairment stage.
Key findings
- Their 3-year progression rate to Alzheimer's disease-type dementia was 50% compared to 21% for subjects without prodromal Alzheimer's disease.
- Their 3-year progression rate to Alzheimer's disease-type dementia was 61% compared to 22% for subjects without prodromal Alzheimer's disease.
- Our findings support the use of the proposed research criteria to identify Alzheimer's disease at the mild cognitive impairment stage.
Why it matters
In this study, people with prodromal Alzheimer's disease at the mild cognitive impairment stage had 3-year progression rates to Alzheimer's disease-type dementia of 50% and 61%, compared with 21% and 22% in those without prodromal Alzheimer's disease. The findings support using the proposed research criteria to identify Alzheimer's disease at the mild cognitive impairment stage, which may help identify people for future treatment studies.
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Study details
- Participants1,607
- Evidence strengthLow
How this study scored 63/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | 4 / 4 | Brain: journal h-index 503 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,607 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 382 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 29.4 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 5 / 6 | Cited 28.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 33 other studies in this library |
| Still being cited | 3 / 4 | Cited 74 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Pieter Jelle Visser: h-index 90 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Oxford: institution h-index 2,205 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 48 institution(s) in 12 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 25693589) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 63 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Vos, S. J., Verhey, F., Frölich, L., Kornhuber, J., Wiltfang, J., Maier, W., et al. (2015). Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage. Brain : a journal of neurology. https://doi.org/10.1093/brain/awv029
Vancouver
Vos SJ, Verhey F, Frölich L, Kornhuber J, Wiltfang J, Maier W, et al. Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage. Brain : a journal of neurology. 2015. doi:10.1093/brain/awv029. PMID: 25693589.
BibTeX
@article{vos2015-25693589,
author = {Vos, S. J. and Verhey, F. and Frölich, L. and Kornhuber, J. and Wiltfang, J. and Maier, W. and Peters, O. and Rüther, E. and others},
title = {{Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage}},
journal = {Brain : a journal of neurology},
year = {2015},
doi = {10.1093/brain/awv029},
pmid = {25693589},
url = {https://doi.org/10.1093/brain/awv029}
}
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