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Mapping CSF biomarker profiles onto NIA-AA guidelines for Alzheimer's disease
Panagiotis Alexopoulos, Jennifer Roesler, Nathalie Thierjung, Lukas Werle, Dorothea Buck, Igor Yakushev, Lena Gleixner, Simone Kagerbauer et al.. European archives of psychiatry and clinical neuroscience, 2015-08-08
Topic: Plasma and spinal-fluid biomarkers
The National Institute on Aging-Alzheimer's Association (NIA-AA) guidelines for Alzheimer's disease (AD) propose the categorization of individuals according to their biomarker constellation. Though the NIA-AA criteria for preclinical AD and AD dementia have already been applied in conjunction with imaging AD biomarkers, the application of the criteria using comprehensive cerebrospinal fluid (CSF) biomarker information has not been thoroughly studied yet. The study included a monocentric cohort with healthy (N = 41) and disease (N = 22) controls and patients with AD dementia (N = 119), and a multicentric sample with healthy controls (N = 116) and patients with AD dementia (N = 102). The CSF biomarkers β-amyloid 1-42, total tau, and phosphorylated tau at threonine 181 were measured with commercially available assays. Biomarker values were trichotomized into positive for AD, negative, or borderline. In controls the presence of normal CSF profiles varied between 13.6 and 25.4 % across the studied groups, while up to 8.6 % of them had abnormal CSF biomarkers. In 40.3-52.9 % of patients with AD dementia, a typical CSF profile for AD was detected. Approximately 40 % of the potential biomarker constellations are not considered in the NIA-AA guidelines, and more than 40 % of participants could not be classified into the NIA-AA categories with distinct biomarker constellations. Here, a refined scheme covering all potential biomarker constellations is proposed. These results enrich the discussion on the NIA-AA guidelines and point to a discordance between clinical symptomatology and CSF biomarkers even in patients with full-blown AD dementia, who are supposed to have a clearly positive for AD neurochemical profile.
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APA 7th
Alexopoulos, P., Roesler, J., Thierjung, N., Werle, L., Buck, D., Yakushev, I., et al. (2016). Mapping CSF biomarker profiles onto NIA-AA guidelines for Alzheimer's disease. European archives of psychiatry and clinical neuroscience. https://doi.org/10.1007/s00406-015-0628-7
Vancouver
Alexopoulos P, Roesler J, Thierjung N, Werle L, Buck D, Yakushev I, et al. Mapping CSF biomarker profiles onto NIA-AA guidelines for Alzheimer's disease. European archives of psychiatry and clinical neuroscience. 2016. doi:10.1007/s00406-015-0628-7. PMID: 26253588.
BibTeX
@article{alexopoulos2016-26253588,
author = {Alexopoulos, Panagiotis and Roesler, Jennifer and Thierjung, Nathalie and Werle, Lukas and Buck, Dorothea and Yakushev, Igor and Gleixner, Lena and Kagerbauer, Simone and others},
title = {{Mapping CSF biomarker profiles onto NIA-AA guidelines for Alzheimer's disease}},
journal = {European archives of psychiatry and clinical neuroscience},
year = {2016},
doi = {10.1007/s00406-015-0628-7},
pmid = {26253588},
url = {https://doi.org/10.1007/s00406-015-0628-7}
}
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Key findings
- These results enrich the discussion on the NIA-AA guidelines and point to a discordance between clinical symptomatology and CSF biomarkers even in patients with full-blown AD dementia, who are supposed to have a clearly positive for AD neurochemical profile.
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Study details
- Participants41
- Evidence strengthModerate
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and free to read, so those were left out: it earned 29 of the 59 points we could judge it on, which is 49 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European archives of psychiatry and clinical neuroscience) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 41 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | 2 / 3 | PubMed indexes it as a multicentre study |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26253588) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 29 / 59 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 29 of the 59 points we could judge it on is 49 out of 100. |
| Total | 49 / 100 | — |
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