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Inflammation in Alzheimer's Disease and Molecular Genetics: Recent Update
Zhang ZG, Li Y, Ng CT, Song YQ.. Archivum immunologiae et therapiae experimentalis, 2015-08-01
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease (AD) is a complex age-related neurodegenerative disorder of the central nervous system. Since the first description of AD in 1907, many hypotheses have been established to explain its causes. Pathological and biochemical studies of brains from AD individuals have provided solid evidence of the activation of inflammatory pathways.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zhang, Z. G., Li, Y., Ng, C. T., & Song, Y. Q. (2015). Inflammation in Alzheimer's Disease and Molecular Genetics: Recent Update. Archivum immunologiae et therapiae experimentalis. https://doi.org/10.1007/s00005-015-0351-0
Vancouver
Zhang ZG, Li Y, Ng CT, Song YQ. Inflammation in Alzheimer's Disease and Molecular Genetics: Recent Update. Archivum immunologiae et therapiae experimentalis. 2015. doi:10.1007/s00005-015-0351-0. PMID: 26232392.
BibTeX
@article{zhang2015-26232392,
author = {Zhang, Z. G. and Li, Y. and Ng, C. T. and Song, Y. Q.},
title = {{Inflammation in Alzheimer's Disease and Molecular Genetics: Recent Update}},
journal = {Archivum immunologiae et therapiae experimentalis},
year = {2015},
doi = {10.1007/s00005-015-0351-0},
pmid = {26232392},
url = {https://doi.org/10.1007/s00005-015-0351-0}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Since the first description of AD in 1907, many hypotheses have been established to explain its causes.
- Pathological and biochemical studies of brains from AD individuals have provided solid evidence of the activation of inflammatory pathways.
- Furthermore, people with long-term medication of anti-inflammatory drugs have shown a reduced risk to develop the disease.
- After three decades of genetic study in AD, dozens of loci harboring genetic variants influencing inflammatory pathways in AD patients has been identified through genome-wide association studies (GWAS).
Why it matters
This review reports that inflammatory pathways are activated in Alzheimer's disease brains and that people on long-term anti-inflammatory drugs have shown a reduced risk of developing the disease. It is a review of existing evidence, not a clinical trial, so it does not establish that anti-inflammatory drugs treat or prevent Alzheimer's.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archivum immunologiae et therapiae experimentalis) |
| Journal's citation record | 1 / 4 | Archivum Immunologiae et Therapiae Experimentalis: journal h-index 83 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 86 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.6 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 3 / 6 | Cited 6.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 7 other studies in this library |
| Still being cited | 2 / 4 | Cited 17 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author You‐Qiang Song: h-index 49 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Hong Kong: institution h-index 1,069 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26232392) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1007/s00005-015-0351-0
- PubMed: 26232392
- Original source →
- Free full text: Archivum Immunologiae et Therapiae Experimentalis →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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