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Vascular dysfunction in the pathogenesis of Alzheimer's disease--A review of endothelium-mediated mechanisms and ensuing vicious circles
Di Marco LY, Venneri A, Farkas E, Evans PC, Marzo A, Frangi AF.. Neurobiology of disease, 2015-08-23
Topic: Amyloid, tau and blood-test diagnosis
Late-onset dementia is a major health concern in the ageing population. Alzheimer's disease (AD) accounts for the largest proportion (65-70%) of dementia cases in the older population. Despite considerable research effort, the pathogenesis of late-onset AD remains unclear.
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APA 7th
Di Marco, L. Y., Venneri, A., Farkas, E., Evans, P. C., Marzo, A., & Frangi, A. F. (2015). Vascular dysfunction in the pathogenesis of Alzheimer's disease--A review of endothelium-mediated mechanisms and ensuing vicious circles. Neurobiology of disease. https://doi.org/10.1016/j.nbd.2015.08.014
Vancouver
Di Marco LY, Venneri A, Farkas E, Evans PC, Marzo A, Frangi AF. Vascular dysfunction in the pathogenesis of Alzheimer's disease--A review of endothelium-mediated mechanisms and ensuing vicious circles. Neurobiology of disease. 2015. doi:10.1016/j.nbd.2015.08.014. PMID: 26311408.
BibTeX
@article{dimarco2015-26311408,
author = {Di Marco, L. Y. and Venneri, A. and Farkas, E. and Evans, P. C. and Marzo, A. and Frangi, A. F.},
title = {{Vascular dysfunction in the pathogenesis of Alzheimer's disease--A review of endothelium-mediated mechanisms and ensuing vicious circles}},
journal = {Neurobiology of disease},
year = {2015},
doi = {10.1016/j.nbd.2015.08.014},
pmid = {26311408},
url = {https://doi.org/10.1016/j.nbd.2015.08.014}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Alzheimer's disease (AD) accounts for the largest proportion (65-70%) of dementia cases in the older population.
- Despite considerable research effort, the pathogenesis of late-onset AD remains unclear.
- Substantial evidence suggests that the neurodegenerative process is initiated by chronic cerebral hypoperfusion (CCH) caused by ageing and cardiovascular conditions.
- CCH causes reduced oxygen, glucose and other nutrient supply to the brain, with direct damage not only to the parenchymal cells, but also to the blood-brain barrier (BBB), a key mediator of cerebral homeostasis.
Why it matters
This review proposes that chronic cerebral hypoperfusion caused by ageing and cardiovascular conditions may initiate the neurodegenerative process in late-onset Alzheimer's disease. It is a review of a proposed mechanism and does not provide a treatment, cure, or prevention.
Study details
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of disease) |
| Journal's citation record | 2 / 4 | Neurobiology of Disease: journal h-index 225 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 265 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 20.4 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 4 / 6 | Cited 14.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 12 other studies in this library |
| Still being cited | 2 / 4 | Cited 37 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Alejandro Federico Frangi: h-index 77 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Sheffield: institution h-index 1,017 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26311408) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.nbd.2015.08.014
- PubMed: 26311408
- Original source →
- Free full text: SZTE Publicatio Repozitórium (University of Szeged) →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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