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Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus
Hui Ming Khoo, Haruhiko Kishima, Naoki Tani, Satoru Oshino, Tomoyuki Maruo, Koichi Hosomi, Takufumi Yanagisawa, Hiroaki Kazui et al.. Journal of neurosurgery, 2015-08-21
Topic: Brain imaging, connectivity and assessment
Both ROI-based and voxel-based analyses revealed reduced DMN connectivity in patients with iNPH. ROI-based analysis showed increased DMN connectivity with worsening clinical symptoms of iNPH. Consistently, voxel-based analyses revealed that DMN connectivity correlated positively with the iNPHGS score, as well as the cognitive and urinary continence domain scores, and negatively with the FAB score. The significant peak in correlation in each case was localized to the precuneus. This is the first study to establish alterations in the DMN of patients with iNPH. DMN connectivity may be a useful indicator of the severity of clinical symptoms in patients with iNPH.
Key findings
- Both ROI-based and voxel-based analyses revealed reduced DMN connectivity in patients with iNPH.
- ROI-based analysis showed increased DMN connectivity with worsening clinical symptoms of iNPH.
- Consistently, voxel-based analyses revealed that DMN connectivity correlated positively with the iNPHGS score, as well as the cognitive and urinary continence domain scores, and negatively with the FAB score.
- The significant peak in correlation in each case was localized to the precuneus.
- This is the first study to establish alterations in the DMN of patients with iNPH.
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Study details
- Evidence strengthLow
How this study scored 38/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 21 of the 56 points we could judge it on, which is 38 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neurosurgery) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26295919) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 21 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 21 of the 56 points we could judge it on is 38 out of 100. |
| Total | 38 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Khoo, H. M., Kishima, H., Tani, N., Oshino, S., Maruo, T., Hosomi, K., et al. (2016). Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus. Journal of neurosurgery. https://doi.org/10.3171/2015.1.jns141633
Vancouver
Khoo HM, Kishima H, Tani N, Oshino S, Maruo T, Hosomi K, et al. Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus. Journal of neurosurgery. 2016. doi:10.3171/2015.1.jns141633. PMID: 26295919.
BibTeX
@article{khoo2016-26295919,
author = {Khoo, Hui Ming and Kishima, Haruhiko and Tani, Naoki and Oshino, Satoru and Maruo, Tomoyuki and Hosomi, Koichi and Yanagisawa, Takufumi and Kazui, Hiroaki and others},
title = {{Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus}},
journal = {Journal of neurosurgery},
year = {2016},
doi = {10.3171/2015.1.jns141633},
pmid = {26295919},
url = {https://doi.org/10.3171/2015.1.jns141633}
}
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