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Cerebral Vasoreactivity, Apolipoprotein E, and the Risk of Dementia: A Population-Based Study
Wolters FJ, de Bruijn RF, Hofman A, Koudstaal PJ, Ikram MA, Heart Brain Connection Collaborative Research Group.. Arteriosclerosis, thrombosis, and vascular biology, 2015-11-19
Topic: Risk, prevention and care in population studies
Objective Cerebral vasoreactivity (CVR) is a key factor in maintenance of continuous cerebral perfusion and a marker of (micro)vascular damage. We aimed to determine the longitudinal relation between CVR and the risk of dementia in the general population. Approach and results We determined CVR in nondemented participants who underwent transcranial Doppler with induced hypercapnia from 1997 to 1999, as part of the ongoing population-based Rotterdam Study.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Wolters, F. J., de Bruijn, R. F., Hofman, A., Koudstaal, P. J., Ikram, M. A., & Heart Brain Connection Collaborative Research Group. (2016). Cerebral Vasoreactivity, Apolipoprotein E, and the Risk of Dementia: A Population-Based Study. Arteriosclerosis, thrombosis, and vascular biology. https://doi.org/10.1161/atvbaha.115.306768
Vancouver
Wolters FJ, de Bruijn RF, Hofman A, Koudstaal PJ, Ikram MA, Heart Brain Connection Collaborative Research Group. Cerebral Vasoreactivity, Apolipoprotein E, and the Risk of Dementia: A Population-Based Study. Arteriosclerosis, thrombosis, and vascular biology. 2016. doi:10.1161/atvbaha.115.306768. PMID: 26586657.
BibTeX
@article{wolters2016-26586657,
author = {Wolters, F. J. and de Bruijn, R. F. and Hofman, A. and Koudstaal, P. J. and Ikram, M. A. and {Heart Brain Connection Collaborative Research Group}},
title = {{Cerebral Vasoreactivity, Apolipoprotein E, and the Risk of Dementia: A Population-Based Study}},
journal = {Arteriosclerosis, thrombosis, and vascular biology},
year = {2016},
doi = {10.1161/atvbaha.115.306768},
pmid = {26586657},
url = {https://doi.org/10.1161/atvbaha.115.306768}
}
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Key findings
- We aimed to determine the longitudinal relation between CVR and the risk of dementia in the general population.
- Approach and results We determined CVR in nondemented participants who underwent transcranial Doppler with induced hypercapnia from 1997 to 1999, as part of the ongoing population-based Rotterdam Study.
- We used a Cox model to determine the risk of dementia in relation to CVR, adjusted for age, sex, cardiovascular risk factors, and carotid intima-media thickness.
- We furthermore determined decline on a cognitive test battery in relation to CVR, using linear mixed models.
Why it matters
This population-based Rotterdam Study examined whether cerebral vasoreactivity relates to the risk of dementia over time. It is an observational study, so it cannot show that improving vasoreactivity prevents dementia.
Study details
- Study designlongitudinal study
- Participants1,629
- Effect size46.2%
- Evidence strengthModerate
How this study scored 58/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Arteriosclerosis, thrombosis, and vascular biology) |
| Journal's citation record | 3 / 4 | Arteriosclerosis Thrombosis and Vascular Biology: journal h-index 340 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,629 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 57 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.8 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 3 / 6 | Cited 3.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 1 / 4 | Cited 12 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author M. Arfan Ikram: h-index 167 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Erasmus MC: institution h-index 1,321 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26586657) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 58 / 100 | — |
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