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38/100

✓ Peer-reviewed alzhub usefulness score 38 out of 100. Drug development

Topic: Disease mechanisms in lab and animal studies

Small molecular weight compounds able to inhibit formation of tau oligomers and fibrils have already been tested for Alzheimer's disease (AD) treatment. The most advanced tau aggregation inhibitor (TAI) is methylthioninium (MT), a drug existing in equilibrium between a reduced (leuco-methylthioninium) and oxidized form (MT(+)). MT chloride (also known as methylene blue) was investigated in a 24-week Phase II study in 321 mild-to-moderate AD patients at the doses of 69, 138, and 228 mg/day. This trial failed to show significant positive effects of MT in the overall patient population. The dose of 138 mg/day showed potential benefits on cognitive performance of moderately affected patients and cerebral blood flow in mildly affected patients. A follow-up compound (TRx0237) claimed to be more bioavailable and less toxic than MT, is now being developed. Phase III clinical trials on this novel TAI in AD and in the behavioral variant of frontotemporal dementia are underway.

Key findings

This trial failed to show significant positive effects of MT in the overall patient population.

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Study details

Evidence strengthLow

How this study scored 38/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 21 of the 56 points we could judge it on, which is 38 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Expert review of neurotherapeutics)
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2016 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multi-centre collaboration	— / 3	Institutions not listed — left out of this score
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 26822031)
Free to read	— / 2	Access not recorded — left out of this score
Points	21 / 56	Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 21 of the 56 points we could judge it on is 38 out of 100.
Total	38 / 100	—

What each of these 20 components measures, and what this score is not →

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Seripa, D., Solfrizzi, V., Imbimbo, B. P., Daniele, A., Santamato, A., Lozupone, M., et al. (2016). Tau-directed approaches for the treatment of Alzheimer's disease: focus on leuco-methylthioninium. Expert review of neurotherapeutics. https://doi.org/10.1586/14737175.2016.1140039

Vancouver

Seripa D, Solfrizzi V, Imbimbo BP, Daniele A, Santamato A, Lozupone M, et al. Tau-directed approaches for the treatment of Alzheimer's disease: focus on leuco-methylthioninium. Expert review of neurotherapeutics. 2016. doi:10.1586/14737175.2016.1140039. PMID: 26822031.

BibTeX

@article{seripa2016-26822031,
  author  = {Seripa, Davide and Solfrizzi, Vincenzo and Imbimbo, Bruno P and Daniele, Antonio and Santamato, Andrea and Lozupone, Madia and Zuliani, Giovanni and Greco, Antonio and others},
  title   = {{Tau-directed approaches for the treatment of Alzheimer's disease: focus on leuco-methylthioninium}},
  journal = {Expert review of neurotherapeutics},
  year    = {2016},
  doi     = {10.1586/14737175.2016.1140039},
  pmid    = {26822031},
  url     = {https://doi.org/10.1586/14737175.2016.1140039}
}

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