Newest studies

Redox proteomics identification of specifically carbonylated proteins in the hippocampi of triple transgenic Alzheimer's disease mice at its earliest pathological stage

35/100 ✓ Peer-reviewed Digital health tools Journal of proteomics

Key finding: Increasing evidences indicate that oxidative stress is an early event of neurodegeneration, however the pathogenic mechanism of AD remains unclarified. +4 more findings

• Brain Biology

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Sleep-disordered breathing advances cognitive decline in the elderly

57/100 ✓ Peer-reviewed How common it is Neurology

Key finding: Our findings in CPAP+ participants suggest that CPAP treatment of SDB may delay progression of cognitive impairment. +3 more findings

• Lifestyle

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The lower hippocampus global connectivity, the higher its local metabolism in Alzheimer disease

53/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: In both patient groups, intrinsic connectivity between hippocampus and precuneus was significantly reduced. +2 more findings

• Brain Scans

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Exercise programs for people with dementia

75/100 ✓ Peer-reviewed Prevention and risk The Cochrane database of systematic reviews

Key finding: Main results Seventeen trials with 1067 participants met the inclusion criteria. +4 more findings

• Lifestyle

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Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial

67/100 ✓ Peer-reviewed Treatments The American journal of clinical nutrition

Key finding: There was a significant interaction (P = 0.024) between B vitamin treatment and plasma combined ω-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) on brain atrophy rates. +4 more findings

• Clinical Trials
• Brain Scans
• Lifestyle

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Which unmet needs contribute to behavior problems in persons with advanced dementia?

36/100 ✓ Peer-reviewed Health systems and care delivery Psychiatry research

Key finding: The Unmet Needs Model states that problem behaviors of people with dementia result from unmet needs stemming from a decreased ability to communicate those needs and to provide for oneself. +2 more findings

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Brain morphology links systemic inflammation to cognitive function in midlife adults

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain, behavior, and immunity

Key finding: Inflammation and adiposity might relate to cognitive decline via influences on brain morphology. +1 more finding

• Brain Scans
• Brain Biology

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A systematic review of barriers and facilitators to and interventions for proxy decision-making by family carers of people with dementia

64/100 ✓ Peer-reviewed End-of-life care International psychogeriatrics

Key finding: We recommend development and testing of decision aids targeting the decisions carers report finding most distressing, including those around where people should live, accessing services, and end of life treatments. +1 more finding

• Caregiving
• End-of-Life Care

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A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease

54/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's research & therapy

Key finding: Despite significant progress, a disease-modifying therapy for Alzheimer's disease (AD) has not yet been developed. +3 more findings

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Brain glutathione levels--a novel biomarker for mild cognitive impairment and Alzheimer's disease

48/100 ✓ Peer-reviewed Mild cognitive impairment Biological psychiatry

Key finding: Extant data from in vivo animal models and postmortem studies indicate that Alzheimer's disease (AD) pathology is associated with reduction of the brain antioxidant glutathione (GSH), yet direct clinical evidence has been lacking. +1 more finding

• Early Stage
• Biomarkers

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Importance and impact of preanalytical variables on Alzheimer disease biomarker concentrations in cerebrospinal fluid

42/100 ✓ Peer-reviewed Tau biomarkers Clinical chemistry

Key finding: Analyses of cerebrospinal fluid (CSF) biomarkers (β-amyloid protein, total tau protein, and hyperphosphorylated tau protein) are part of the diagnostic criteria of Alzheimer disease. +3 more findings

• Biomarkers

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Prevalence of post-stroke cognitive impairment in china: a community-based, cross-sectional study

59/100 ✓ Peer-reviewed Disparities PloS one

Key finding: The overall prevalence of PSCI was 80.97% (95%CI: 77.82%-84.11%), while that of non-dementia PSCI (PSCI-ND) and post-stroke vascular dementia (PSD) was 48.91% (95%CI: 44.91%-52.92%) and 32.05% (95%CI: 28.32%-35.79%), respectively. +1 more finding

• Diagnosis

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Amyloid and FDG-PET study of logopenic primary progressive aphasia: evidence for the existence of two subtypes

45/100 ✓ Peer-reviewed Biomarkers Journal of neurology

Key finding: The logopenic variant of primary progressive aphasia (lvPPA) has been associated with Alzheimer disease, although this relationship is still subject to debate. +3 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

What lessons can be learned from failed Alzheimer's disease trials?

38/100 ✓ Peer-reviewed Treatments Expert review of clinical pharmacology

Key finding: In some trials, drugs appear not to have achieved biochemical effect thresholds sufficient for clinical benefit. +4 more findings

• Treatments

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Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

40/100 ✓ Peer-reviewed Risk factors Frontiers in cellular neuroscience

Key finding: Neurotoxic metals such as lead, mercury, aluminum, cadmium and arsenic, as well as some pesticides and metal-based nanoparticles have been involved in AD due to their ability to increase beta-amyloid (Aβ) peptide and the phosphorylation of Tau protein (P-Tau), causing senile/amyloid plaques and neurofibrillary tangles (NFTs) characteristic of AD. +4 more findings

• Risk Factors
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Memantine monotherapy for Alzheimer's disease: a systematic review and meta-analysis

83/100 ✓ Peer-reviewed Treatments PloS one

Key finding: Memantine monotherapy improved cognition, behavior, activities of daily living, global function, and stage of dementia and was well-tolerated by AD patients. +4 more findings

• Treatments
• Side Effects

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Rivastigmine for Alzheimer's disease

73/100 ✓ Peer-reviewed Treatments The Cochrane database of systematic reviews

Key finding: Tacrine, the first of the cholinesterase inhibitors to undergo extensive trials for this purpose, was associated with significant adverse effects including hepatotoxicity. +3 more findings

• Treatments

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TREM2 is associated with increased risk for Alzheimer's disease in African Americans

67/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

Key finding: TREM2 encodes for triggering receptor expressed on myeloid cells 2 and has rare, coding variants that associate with risk for late-onset Alzheimer's disease (LOAD) in Caucasians of European and North-American origin. +3 more findings

• Genetics
• Health Equity

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Mild cognitive impairment and its management in older people

45/100 ✓ Peer-reviewed Prevention and risk Clinical interventions in aging

Key finding: MCI does not interfere significantly with individuals' daily activities.

• Early Stage
• Prevention
• Lifestyle

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Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease

63/100 ✓ Peer-reviewed Genetics Circulation

Key finding: By conditioning on the genetic association with the cardiovascular phenotypes, we identify novel AD susceptibility loci, including 2 genome-wide significant variants conferring increased risk for AD. +2 more findings

• Genetics

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BMI and risk of dementia in two million people over two decades: a retrospective cohort study

66/100 ✓ Peer-reviewed How common it is The lancet. Diabetes & endocrinology

Key finding: Our cohort of 1,958,191 people from UK general practices had a median age at baseline of 55 years (IQR 45-66) and a median follow-up of 9·1 years (IQR 6·3-12·6). +3 more findings

• Risk Factors

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Neuropsychiatric symptoms and caregiver's burden in Parkinson's disease

51/100 ✓ Peer-reviewed Caregiving Parkinsonism & related disorders

Key finding: The most frequent NPS were depression (in 66% of the sample), anxiety (65%) and mental fatigue (57%). +2 more findings

• Caregiving
• Other Dementias

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Organotypic vibrosections from whole brain adult Alzheimer mice (overexpressing amyloid-precursor-protein with the Swedish-Dutch-Iowa mutations) as a model to study clearance of beta-amyloid plaques

41/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

Key finding: Incubation of fresh slices for 2 weeks with 1-0.1-0.01 μg/ml of NEP, insulysin, MMP-2, or MMP-9 showed that NEP, insulysin, and MMP-9 markedly degraded beta-amyloid plaques but only at the highest concentration.

• Brain Biology
• Genetics

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Multidimensional determinants of family caregiver burden in Alzheimer's disease

52/100 ✓ Peer-reviewed Caregiving International psychogeriatrics

Key finding: The study results identified that dementia-related factors were the most significant factors, representing 25.6% of caregiver burden and were followed by caregiving-related factors explaining caregiver burden significantly. +2 more findings

• Caregiving

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Neuronal pentraxin 1 negatively regulates excitatory synapse density and synaptic plasticity

38/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Moreover, we found that NP1 regulates the surface expression of the Kv7.2 subunit of the Kv7 family of potassium channels that control neuronal excitability. +1 more finding

• Brain Biology

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