Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 15,726–15,750 of 27,380 studies, newest first · page 630 of 1096.
October 2016 25
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2016-10-11
Perceived Stress and Cognitive Decline in Different Cognitive Domains in a Cohort of Older African Americans
47/100 ✓ Peer-reviewed Disparities The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Research indicates that stress is linked to cognitive dysfunction. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-10-11
[Formula: see text]Practice effects and longitudinal cognitive change in clinically normal older adults differ by Alzheimer imaging biomarker status
51/100 ✓ Peer-reviewed Brain scans and imaging The Clinical neuropsychologist
Key finding: Amyloidosis in the absence of neurodegeneration did not have an adverse impact on practice effects or the 30-month cognitive trajectories. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-11
Research priorities to reduce the global burden of dementia by 2025
61/100 ✓ Peer-reviewed Prevention and risk The Lancet. Neurology
Key finding: Six of the top ten research priorities were focused on prevention, identification, and reduction of dementia risk, and on delivery and quality of care for people with dementia and their carers. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-10
Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons
40/100 ✓ Peer-reviewed Disease mechanisms Scientific reports
Key finding: We found that FTLD-Tau neurons, either with an intronic MAPT mutation or with an exonic mutation, developed accumulation and extracellular release of misfolded tau followed by neuronal death, which we confirmed by correction of the intronic mutation with CRISPR/Cas9. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-10-10
Whole-brain analysis reveals increased neuroanatomical asymmetries in dementia for hippocampus and amygdala
59/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology
Key finding: The hippocampus shows a significant increase in asymmetry longitudinally and both hippocampus and amygdala show a significantly higher asymmetry cross-sectionally concurrent with disease severity above and beyond an ageing effect. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-10
Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association
52/100 ✓ Peer-reviewed Risk factors Hypertension (Dallas, Tex. : 1979)
Key finding: After carefully reviewing the literature, the group concluded that there were insufficient data to make evidence-based recommendations. +2 more findings
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2016-10-08
Pesticides: an update of human exposure and toxicity
38/100 ✓ Peer-reviewed Risk factors Archives of toxicology
Key finding: Pesticides are a family of compounds which have brought many benefits to mankind in the agricultural, industrial, and health areas, but their toxicities in both humans and animals have always been a concern. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-08
Evaluation of early-phase [18F]-florbetaben PET acquisition in clinical routine cases
48/100 ✓ Peer-reviewed Disease mechanisms NeuroImage. Clinical
Key finding: Early-phase FBB acquisitions correlate on a relative quantitative and visual level with FDG PET scans, irrespective of the amyloid plaque density assessed in late FBB imaging. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-08
Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology
41/100 ✓ Peer-reviewed Inflammation and the immune system Aging cell
Key finding: Recent data indicate that microglia and monocyte-derived macrophages (MDM) are key players in the initiation and progression of AD, yet their respective roles remain to be clarified. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-06
Neuroinflammatory and morphological changes in late-life depression: the NIMROD study
38/100 ✓ Peer-reviewed Risk factors The British journal of psychiatry : the journal of mental science
Key finding: We found significantly higher CRP levels in those with late-life depression and raised [11C]PK11195 binding compared with controls in brain regions associated with depression, including subgenual anterior cingulate cortex, and significant hippocampal subfield atrophy in cornu ammonis 1 and subiculum. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-10-06
Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease: ICICLE-PD study
52/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry
Key finding: FDG-PET was performed on a cohort of 79 patients with newly diagnosed PD (mean disease duration 8 months) and 20 unrelated controls. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-06
Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model
47/100 ✓ Peer-reviewed Tau biomarkers Neuron
Key finding: As growing evidence indicates that reducing the steady-state levels of disease-causing proteins mitigates neurodegeneration in animal models, we developed a strategy to screen for genes that decrease the levels of tau, whose accumulation contributes to the pathology of both Alzheimer disease (AD) and progressive supranuclear palsy (PSP). +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-06
Predicting Regional Pattern of Longitudinal β-Amyloid Accumulation by Baseline PET
48/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: Pseudotemporal measurements from baseline PET data explained 87% ( P Pseudotemporal analysis of baseline PET images is capable of predicting the regional pattern of longitudinal Aβ accumulation in AD at a group level. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-05
Female advantage in verbal memory: Evidence of sex-specific cognitive reserve
60/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Women show better verbal memory than men in aMCI despite similar levels of brain hypometabolism. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-04
Genome-wide association analysis of secondary imaging phenotypes from the Alzheimer's disease neuroimaging initiative study
54/100 ✓ Peer-reviewed Genetics NeuroImage
Key finding: The aim of this paper is to systematically evaluate a biased sampling issue associated with genome-wide association analysis (GWAS) of imaging phenotypes for most imaging genetic studies, including the Alzheimer's Disease Neuroimaging Initiative (ADNI). +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-04
Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease
67/100 ✓ Peer-reviewed Biomarkers EMBO molecular medicine
Key finding: Combinations improved the diagnostic accuracy (AUC 85.5% for T-tau, Ng, and NFL) compared to individual biomarkers (T-tau 80.8%; Ng 71.4%; NFL 77.7%). +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-03
Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer's Disease
38/100 ✓ Peer-reviewed Drug development Molecular neurobiology
Key finding: In conclusion, linagliptin possesses neuroprotective properties that may be attributed to the improvement of incretin levels in the brain.
Full summary, score breakdown and related studies → Original source
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2016-10-03
The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer's disease
47/100 ✓ Peer-reviewed Disease mechanisms Alzheimer's research & therapy
Key finding: Cerebrospinal fluid synaptotagmin-1 is a promising biomarker to monitor synaptic dysfunction and degeneration in Alzheimer's disease that may be useful for clinical diagnosis, to monitor effect on synaptic integrity by novel drug candidates, and to explore pathophysiology directly in patients with Alzheimer's disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-01
Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer's Disease
38/100 ✓ Peer-reviewed Risk factors Aging and disease
Key finding: Among patients homozygous for the APOE4 genotype or carrying both APOE4 and family history risks, lower education was associated with a thinner cortex in multiple medial temporal regions, including the hippocampus. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-10-01
Nonvascular retinal imaging markers of preclinical Alzheimer's disease
57/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: The surface area of inclusion bodies increased as a function of cortical amyloid burden. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-01
Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease
36/100 ✓ Peer-reviewed Prevention and risk Nutrition reviews
Key finding: It has been hypothesized that alterations in the composition of the gut microbiota might be associated with the onset of certain human pathologies, such as Alzheimer disease, a neurodegenerative syndrome associated with cerebral accumulation of amyloid-β fibrils. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-01
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015
45/100 ✓ Peer-reviewed Risk factors Lancet (London, England)
Key finding: These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-01
Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer's Disease
43/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease : JAD
Key finding: Greater composite cognitive impairment index was associated with worse performance on all CAB tests. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-01
Shining light on the head: Photobiomodulation for brain disorders
40/100 ✓ Peer-reviewed Vascular contributions BBA clinical
Key finding: There is some evidence that all these seemingly diverse conditions can be beneficially affected by applying light to the head. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-10-01
Benzodiazepine Misuse in the Elderly: Risk Factors, Consequences, and Management
36/100 ✓ Peer-reviewed Clinical safety Current psychiatry reports
Key finding: An emerging concern is a potentially increased risk of dementia.
Full summary, score breakdown and related studies → Original source
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