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Time to diagnosis in young-onset dementia and its determinants: the INSPIRED study
Draper B, Cations M, White F, Trollor J, Loy C, Brodaty H, Sachdev P, Gonski P et al.. International journal of geriatric psychiatry, 2016-01-25
Topic: Risk, prevention and care in population studies
Plain-language summary
Objective The objective of this study is to identify factors determining the time to diagnosis for young-onset dementia (YOD), defined as dementia with symptom onset before age 65 years, by mapping the diagnostic pathways. Methods Participants were recruited via healthcare professionals, community support organisations or were self-referred. Information was obtained by interviews with the person with YOD and their carer, and medical record reviews. Clinical dementia diagnoses were independently ratified by consensus review. Results Participants included 88 people with YOD (mean age of onset = 55.4 years), due to Alzheimer's disease (AD) (53.4%, n = 47), frontotemporal dementia (FTD) (15.9%, n = 14) and other causes (30.7%, n = 27). Median time from symptom onset to first consultation was 2.3 years, to dementia diagnosis 3.2 years, to family awareness of dementia diagnosis 3.5 years and to final diagnosis of the type of dementia 4.7 years. Non-dementia diagnoses occurred in 48.9%, including depression (30.7%) and mild cognitive impairment (MCI) (17.0%). Participants with younger age of onset had significantly longer time to first consultation and family awareness of the dementia diagnosis. The time to dementia diagnosis was significantly longer when the participant presented with MCI or depression and when the dementia was other than AD or FTD. MCI was associated with significantly longer time to family awareness of dementia diagnosis. Conclusions Factors impacting on time to diagnosis vary with the stage of diagnosis in YOD. Longer time to dementia diagnosis occurred in people who were younger at symptom onset, when MCI or depression was present, and in dementias other than AD and FTD. Copyright © 2016 John Wiley & Sons, Ltd.
What this study adds
Evidence grade: Low
The record lists 47 participants. This study of 88 people with young-onset dementia found that the time from symptom onset to dementia diagnosis was often several years and was longer when the person first presented with mild cognitive impairment or depression. Reported effect size: 53.4%; 15.9%; 30.7%.
Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Draper, B., Cations, M., White, F., Trollor, J., Loy, C., Brodaty, H., et al. (2016). Time to diagnosis in young-onset dementia and its determinants: the INSPIRED study. International journal of geriatric psychiatry. https://doi.org/10.1002/gps.4430
Vancouver
Draper B, Cations M, White F, Trollor J, Loy C, Brodaty H, et al. Time to diagnosis in young-onset dementia and its determinants: the INSPIRED study. International journal of geriatric psychiatry. 2016. doi:10.1002/gps.4430. PMID: 26807846.
BibTeX
@article{draper2016-26807846,
author = {Draper, B. and Cations, M. and White, F. and Trollor, J. and Loy, C. and Brodaty, H. and Sachdev, P. and Gonski, P. and others},
title = {{Time to diagnosis in young-onset dementia and its determinants: the INSPIRED study}},
journal = {International journal of geriatric psychiatry},
year = {2016},
doi = {10.1002/gps.4430},
pmid = {26807846},
url = {https://doi.org/10.1002/gps.4430}
}
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Key findings
- Results Participants included 88 people with YOD (mean age of onset = 55.4 years), due to Alzheimer's disease (AD) (53.4%, n = 47), frontotemporal dementia (FTD) (15.9%, n = 14) and other causes (30.7%, n = 27).
- Participants with younger age of onset had significantly longer time to first consultation and family awareness of the dementia diagnosis.
- The time to dementia diagnosis was significantly longer when the participant presented with MCI or depression and when the dementia was other than AD or FTD.
- MCI was associated with significantly longer time to family awareness of dementia diagnosis.
Why it matters
This study of 88 people with young-onset dementia found that the time from symptom onset to dementia diagnosis was often several years and was longer when the person first presented with mild cognitive impairment or depression. It describes diagnostic delays and does not test any treatment or cure.
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Study details
- Participants47
- Effect size53.4%; 15.9%; 30.7%
- Evidence strengthLow
How this study scored 52/100
Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International journal of geriatric psychiatry) |
| Journal's citation record | 2 / 4 | International Journal of Geriatric Psychiatry: journal h-index 190 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 47 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 205 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 17.1 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 4 / 6 | Cited 10.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 11 other studies in this library |
| Still being cited | 3 / 4 | Cited 69 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Adrienne Lee Withall: h-index 28 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | The University of Sydney: institution h-index 1,466 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26807846) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 52 / 100 | — |
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